ID A0A0S7DKJ2_9EURO Unreviewed; 435 AA. AC A0A0S7DKJ2; DT 17-FEB-2016, integrated into UniProtKB/TrEMBL. DT 17-FEB-2016, sequence version 1. DT 08-NOV-2023, entry version 28. DE RecName: Full=M-phase inducer phosphatase {ECO:0000256|RuleBase:RU368028}; DE EC=3.1.3.48 {ECO:0000256|RuleBase:RU368028}; GN ORFNames=CNMCM8060_001454 {ECO:0000313|EMBL:KAF4172480.1}; OS Aspergillus lentulus. OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus. OX NCBI_TaxID=293939 {ECO:0000313|EMBL:KAF4172480.1, ECO:0000313|Proteomes:UP000713487}; RN [1] {ECO:0000313|EMBL:KAF4172480.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CNM-CM8060 {ECO:0000313|EMBL:KAF4172480.1}; RA dos Santos R.A.C., Steenwyk J.L., Rivero-Menendez O., Mead M.E., RA Silva L.P., Bastos R.W., Alastruey-Izquierdo A., Goldman G.H., Rokas A.; RT "Genomic and phenotypic heterogeneity of clinical isolates of the human RT pathogens Aspergillus fumigatus, Aspergillus lentulus and Aspergillus RT fumigatiaffinis."; RL bioRxiv 0:0-0(2020). RN [2] {ECO:0000313|EMBL:KAF4172480.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CNM-CM8060 {ECO:0000313|EMBL:KAF4172480.1}; RA Santos R.A.C., Steenwyk J.L., Rivero-Menendez O., Mead M.E., Silva L.P., RA Bastos R.W., Alastruey-Izquierdo A., Goldman G.H., Rokas A.; RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Functions as a dosage-dependent inducer in mitotic control. CC Tyrosine protein phosphatase required for progression of the cell CC cycle. {ECO:0000256|RuleBase:RU368028}. CC -!- CATALYTIC ACTIVITY: CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, CC ChEBI:CHEBI:82620; EC=3.1.3.48; CC Evidence={ECO:0000256|ARBA:ARBA00001490, CC ECO:0000256|RuleBase:RU368028}; CC -!- SIMILARITY: Belongs to the MPI phosphatase family. CC {ECO:0000256|ARBA:ARBA00011065, ECO:0000256|RuleBase:RU368028}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:KAF4172480.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JAAAPS010000136; KAF4172480.1; -; Genomic_DNA. DR Proteomes; UP000713487; Unassembled WGS sequence. DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-UniRule. DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule. DR GO; GO:1902751; P:positive regulation of cell cycle G2/M phase transition; IEA:InterPro. DR CDD; cd01530; Cdc25; 1. DR Gene3D; 3.40.250.10; Rhodanese-like domain; 1. DR InterPro; IPR000751; MPI_Phosphatase. DR InterPro; IPR001763; Rhodanese-like_dom. DR InterPro; IPR036873; Rhodanese-like_dom_sf. DR PANTHER; PTHR10828:SF17; CDC25-LIKE PROTEIN PHOSPHATASE TWINE-RELATED; 1. DR PANTHER; PTHR10828; M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25; 1. DR Pfam; PF00581; Rhodanese; 1. DR PRINTS; PR00716; MPIPHPHTASE. DR SMART; SM00450; RHOD; 1. DR SUPFAM; SSF52821; Rhodanese/Cell cycle control phosphatase; 1. DR PROSITE; PS50206; RHODANESE_3; 1. PE 3: Inferred from homology; KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU368028}; KW Cell division {ECO:0000256|ARBA:ARBA00022618, KW ECO:0000256|RuleBase:RU368028}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU368028}; KW Mitosis {ECO:0000256|RuleBase:RU368028}; KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912, KW ECO:0000256|RuleBase:RU368028}. SQ SEQUENCE 435 AA; 48839 MW; DCD201B29716632B CRC64; METMDMSPLP HKPPFIVTTE IELNPPTPGG SPIDSPMMSA APSPLQESPL MGPKEDKQER KRPSFLRPSL ARTKAQSFQL GMARPAPESQ APPFKFQTRG AKTSLSASTS LEDMFGESPQ RERPIVRNNS STLLNNPRLR PPLGSGSNGS HARGNGSPSA ASIRKSSHPL MRPRKQCRRS LSMFEHPEDV IAEKEANYTT NAPLQSITDV DTTPSLQLPH FIPEDSADTL PRIDKTILVD LMDGKYNDRF DHIMVVDCRF EYEYEGGHIN GAVNYNDKEY LAAQLFADPK PRTALVLHCE YSAHRAPIMA KYIRHRDRAV NVDHYPQLTY PDMYILDGGY SAFFAEHRSL CFPQNYVEMN AKEHEFACER GLGKVKQRSK LNRAQTFAFG QHSPQMEDSP TGRCRNNSGE RTRFLDSPFE GTPSSRGPGR RMLSY //