ID A0A0S2LM47_9EUTH Unreviewed; 318 AA. AC A0A0S2LM47; DT 17-FEB-2016, integrated into UniProtKB/TrEMBL. DT 17-FEB-2016, sequence version 1. DT 27-MAR-2024, entry version 22. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 1 {ECO:0000256|ARBA:ARBA00021009, ECO:0000256|RuleBase:RU000473}; DE EC=7.1.1.2 {ECO:0000256|ARBA:ARBA00012944, ECO:0000256|RuleBase:RU000473}; GN Name=ND1 {ECO:0000313|EMBL:ALO62463.1}; OS Dasypus pilosus (hairy long-nosed armadillo). OG Mitochondrion {ECO:0000313|EMBL:ALO62463.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Xenarthra; Cingulata; Dasypodidae; Dasypus. OX NCBI_TaxID=1756219 {ECO:0000313|EMBL:ALO62463.1}; RN [1] {ECO:0000313|EMBL:ALO62463.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26556496; DOI=10.1093/molbev/msv250; RA Gibb G.C., Condamine F.L., Kuch M., Enk J., Moraes-Barros N., Superina M., RA Poinar H.N., Delsuc F.; RT "Shotgun Mitogenomics Provides a Reference Phylogenetic Framework and RT Timescale for Living Xenarthrans."; RL Mol. Biol. Evol. 33:621-642(2016). CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000256|ARBA:ARBA00000766, CC ECO:0000256|RuleBase:RU000473}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion CC inner membrane {ECO:0000256|RuleBase:RU000471}; Multi-pass membrane CC protein {ECO:0000256|RuleBase:RU000471}. CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. CC {ECO:0000256|ARBA:ARBA00010535, ECO:0000256|RuleBase:RU000471}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KT818544; ALO62463.1; -; Genomic_DNA. DR AlphaFoldDB; A0A0S2LM47; -. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR HAMAP; MF_01350; NDH1_NuoH; 1. DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO. DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS. DR PANTHER; PTHR11432; NADH DEHYDROGENASE SUBUNIT 1; 1. DR PANTHER; PTHR11432:SF3; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 1; 1. DR Pfam; PF00146; NADHdh; 1. DR PROSITE; PS00667; COMPLEX1_ND1_1; 1. DR PROSITE; PS00668; COMPLEX1_ND1_2; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|ARBA:ARBA00022982}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Mitochondrion {ECO:0000256|RuleBase:RU000473, ECO:0000313|EMBL:ALO62463.1}; KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU000471}; KW Respiratory chain {ECO:0000256|ARBA:ARBA00022660}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU000471}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}; KW Ubiquinone {ECO:0000256|RuleBase:RU000473}. FT TRANSMEM 69..89 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 95..119 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 140..160 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 172..191 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 220..243 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 255..273 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 293..314 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" SQ SEQUENCE 318 AA; 35584 MW; 5B5169DCFB99D916 CRC64; MHLINVLCLI IPILLAVAFL TLLERKILGY MQLRKGPNIV GPYGLLQPIA DAIKLFIKEP LRPATSSKLM FILAPTLALT LALSLWIPIP MPYPLINLNL GVLFILAMSS LAVYSILWSG WASNSKYALI GALRAVAQTI SYEVTLAIIL LSIMMTNGSF TLSTLTTTQE HMWLIFPLWP LAMMWFISTL AETNRAPFDL TEGESELVSG FNVEYAAGPF ALFFLAEYAN IIMMNALTAI LFFGAMHNPM FPELHTLNLV TKTLILTMMF LWVRASYPRF RYDQLMHLLW KSFLPLTLAL CMLHVSAPAT FAGVPPHM //