ID   A0A0R7EZ18_MOUSE        Unreviewed;       287 AA.
AC   A0A0R7EZ18;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   24-JUL-2024, entry version 31.
DE   SubName: Full=MHC class II antigen beta chain {ECO:0000313|EMBL:AKN89449.1};
GN   Name=H2-Eb2 {ECO:0000313|EMBL:AKN89449.1, ECO:0000313|MGI:MGI:95902};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AKN89449.1};
RN   [1] {ECO:0000313|EMBL:AKN89449.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BALB/c {ECO:0000313|EMBL:AKN89449.1};
RA   Monzon-Casanova E., Rudolf R.;
RT   "Characterization and functional analysis of the non-polymorphic MHC class
RT   II molecules RT1-Db2 and H2-Eb2.";
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the MHC class II family.
CC       {ECO:0000256|ARBA:ARBA00007394}.
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DR   EMBL; KP027332; AKN89449.1; -; mRNA.
DR   AlphaFoldDB; A0A0R7EZ18; -.
DR   AGR; MGI:95902; -.
DR   MGI; MGI:95902; H2-Eb2.
DR   GO; GO:0031902; C:late endosome membrane; IBA:GO_Central.
DR   GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR   GO; GO:0042613; C:MHC class II protein complex; IBA:GO_Central.
DR   GO; GO:0023026; F:MHC class II protein complex binding; IBA:GO_Central.
DR   GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IBA:GO_Central.
DR   GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IBA:GO_Central.
DR   GO; GO:0050778; P:positive regulation of immune response; IBA:GO_Central.
DR   GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR050160; MHC/Immunoglobulin.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR014745; MHC_II_a/b_N.
DR   InterPro; IPR000353; MHC_II_b_N.
DR   PANTHER; PTHR19944:SF66; HISTOCOMPATIBILITY 2, CLASS II ANTIGEN E BETA2; 1.
DR   PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00969; MHC_II_beta; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SMART; SM00921; MHC_II_beta; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   2: Evidence at transcript level;
KW   Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   MHC II {ECO:0000256|ARBA:ARBA00023182};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        227..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          125..213
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   REGION          259..287
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   287 AA;  32231 MW;  EF3489C45D295494 CRC64;
     MVSLWLPRGL CVAAVILSLM MVTPPVILVR DPRPRFLEQL KAECHYFNGK ERVWSVTRFI
     YNQEEFARFN SDFGKFLAVT ELGRPIVEYL NTQKDMLDNY RASVDRCRNN YDLVDIFMLN
     LKAEPKVTVY LAKTQPLEHH NLLVCSVIDF YPGSIEVRWF RNGEEEKTGV VSTGLIQNGD
     WTYQTLVMLG TVPRGGEVYT CQVEHLSLTS PVTVEWRTRS TSAQSKLLSG AMGMALGLFI
     LAVGLFFYLR NLRAGSVSHD AGEGAESFTS RLTGSGSECH MGPGLSI
//