ID   A0A0R4J0Q7_MOUSE        Unreviewed;       618 AA.
AC   A0A0R4J0Q7;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   22-FEB-2023, entry version 39.
DE   SubName: Full=Leucine-rich repeat and immunoglobulin-like domain-containing-NOGO receptor-interacting protein 4 {ECO:0000313|Ensembl:ENSMUSP00000058050};
GN   Name=Lingo4 {ECO:0000313|Ensembl:ENSMUSP00000058050,
GN   ECO:0000313|MGI:MGI:2444651};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000058050, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000058050, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000058050,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000058050}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000058050};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
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DR   RefSeq; NP_796224.1; NM_177250.2.
DR   AlphaFoldDB; A0A0R4J0Q7; -.
DR   SMR; A0A0R4J0Q7; -.
DR   ProteomicsDB; 330966; -.
DR   Antibodypedia; 34074; 88 antibodies from 19 providers.
DR   DNASU; 320747; -.
DR   Ensembl; ENSMUST00000050975.6; ENSMUSP00000058050.4; ENSMUSG00000044505.6.
DR   GeneID; 320747; -.
DR   KEGG; mmu:320747; -.
DR   AGR; MGI:2444651; -.
DR   CTD; 339398; -.
DR   MGI; MGI:2444651; Lingo4.
DR   VEuPathDB; HostDB:ENSMUSG00000044505; -.
DR   OMA; VLCAHRR; -.
DR   OrthoDB; 2911036at2759; -.
DR   PhylomeDB; A0A0R4J0Q7; -.
DR   BioGRID-ORCS; 320747; 2 hits in 76 CRISPR screens.
DR   Proteomes; UP000000589; Chromosome 3.
DR   Bgee; ENSMUSG00000044505; Expressed in olfactory pit and 26 other tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   PANTHER; PTHR45842:SF12; KEKKON 5, ISOFORM A; 1.
DR   PANTHER; PTHR45842; SYNAPTIC ADHESION-LIKE MOLECULE SALM; 1.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF13855; LRR_8; 4.
DR   PRINTS; PR00019; LEURICHRPT.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00369; LRR_TYP; 10.
DR   SMART; SM00082; LRRCT; 1.
DR   SMART; SM00013; LRRNT; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS51450; LRR; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        557..582
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          437..527
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
SQ   SEQUENCE   618 AA;  66823 MW;  D4AB897C3FF14A47 CRC64;
     MGQAPALERC SAQLDATPQL LRPQGMDAAT APKQAWLPWS PLLFLLLLPG GSISSCPTVC
     DCTSQTRAVF CAHRRLDTIP GGLPLDTELL DLSGNRLWGL QRGMLSRLGQ LQELDLSYNQ
     LSTLEPGAFH GLQSLLTLRL QGNRLRIVGP GIFSGLTALT LLDLRLNQIV LFLDGAFSEL
     GSLQQLEVGD NHLVFVAPGA FAGLAKLSTI TLERCNLSTV PGLALAQLPA LVALRLRELD
     IERLPAGALR GLGQLKELEI HHWPSLEALD PGSLVGLNLS SLAITRCNLS SVPFQALHHL
     SFLRILDLSQ NPISAIPARR LSPLVRLQEL RLSGACLTSI AAHAFHGLTA FHLLDVADNA
     LQTLEETAFP SPDKLVTLRL SGNPLTCDCR LLWLLRLRRR LDFGTSPPAC AGPQHVQGKS
     LREFSDILPP GHFTCKPALI RKSGPRWVIA EEGGHAVFSC SGDGDPAPTV SWMRPQGAWL
     GRVGRVRVLE DGTLEIRSVQ LRDRGAYVCV VSNVAGNDSL RTWLEVIQVE PPNGTLSDPN
     ITMPGIPGPF FLDSRGVAMV LAVGFLPFLT SVTLCFGLIA LWSKGKGRVK HHMTFDFVAP
     RPSGDKNSGG NRVTAKLF
//