ID A0A0R2QY66_9ACTN Unreviewed; 1058 AA. AC A0A0R2QY66; DT 20-JAN-2016, integrated into UniProtKB/TrEMBL. DT 20-JAN-2016, sequence version 1. DT 13-SEP-2023, entry version 26. DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417}; DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417}; GN ORFNames=ABR62_02440 {ECO:0000313|EMBL:KRO53634.1}; OS Actinobacteria bacterium BACL2 MAG-120820-bin50. OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetes incertae sedis; OC ac1 cluster. OX NCBI_TaxID=1655570 {ECO:0000313|EMBL:KRO53634.1, ECO:0000313|Proteomes:UP000053054}; RN [1] {ECO:0000313|EMBL:KRO53634.1, ECO:0000313|Proteomes:UP000053054} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BACL2 MAG-120820-bin50 {ECO:0000313|EMBL:KRO53634.1}; RA Hugerth L.W., Larsson J., Alneberg J., Lindh M.V., Legrand C., Pinhassi J., RA Andersson A.F.; RT "Metagenome-Assembled Genomes uncover a global brackish microbiome."; RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, CC ChEBI:CHEBI:173112; EC=2.7.7.7; CC Evidence={ECO:0000256|ARBA:ARBA00024632}; CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:KRO53634.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LIAU01000041; KRO53634.1; -; Genomic_DNA. DR AlphaFoldDB; A0A0R2QY66; -. DR Proteomes; UP000053054; Unassembled WGS sequence. DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro. DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW. DR CDD; cd04485; DnaE_OBF; 1. DR CDD; cd07431; PHP_PolIIIA; 1. DR Gene3D; 1.10.150.870; -; 1. DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1. DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1. DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom. DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom. DR InterPro; IPR040982; DNA_pol3_finger. DR InterPro; IPR004805; DnaE2/DnaE/PolC. DR InterPro; IPR029460; DNAPol_HHH. DR InterPro; IPR004013; PHP_dom. DR InterPro; IPR003141; Pol/His_phosphatase_N. DR InterPro; IPR016195; Pol/histidinol_Pase-like. DR NCBIfam; TIGR00594; polc; 1. DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1. DR PANTHER; PTHR32294:SF4; ERROR-PRONE DNA POLYMERASE; 1. DR Pfam; PF07733; DNA_pol3_alpha; 1. DR Pfam; PF17657; DNA_pol3_finger; 1. DR Pfam; PF14579; HHH_6; 1. DR Pfam; PF02811; PHP; 1. DR SMART; SM00481; POLIIIAc; 1. DR SUPFAM; SSF89550; PHP domain-like; 1. PE 4: Predicted; KW DNA replication {ECO:0000256|ARBA:ARBA00022705}; KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932}; KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}. FT DOMAIN 4..71 FT /note="Polymerase/histidinol phosphatase N-terminal" FT /evidence="ECO:0000259|SMART:SM00481" SQ SEQUENCE 1058 AA; 117267 MW; 7C0622CBB5E2DD8B CRC64; MSFTHLHLAS GFSFKYGTTL PHLLVEKARD FGMSSLALTD RDGLYGAIRF TQSCVENGIT PIIGVDITCK NQSRITLLAT PGKGWRSLVR VVSELKSYGE CDLDFLKKHS NYTSNLISLQ GPDSLIARAI TNRQYEKALS LYNDSRELFQ SQVIEIVSHL IYGDGPRSTT HASRMFGFAQ DNDLPAILSN AARMCLRQDA PIADILDASR RLLPLHKNVV ERENSEAFLK SSQEMHHLAE IITRASGQRN SRKLLSTTQD LAKQAELSPS QDIGLGSIHL PEPELLGAKN QDELTLQLRQ RSIAGINWRY GQSNSEVNQR LEKELEIIKS LGFESYFLTV ADITDRARAS GIRVAARGSG AGSLICHLLG ISGVEPLSLG LLMERFCSPL RRALPDIDID VESARRLEIY DQVFANYPMR SATVAMFDTY RARHAIRDVG AALSLAPMEI DLVAKSLPHI RARNISQALI NLPELANLNI TSPIWKMAVG LAERLDGLPR NVAMHPCAVV ISSAELYQRA PIEINASNYP MVQWDKDDVE AIGLLKLDIL GVRMQSSLAY AISEIERSTG KVIDIDAIAL DDSETFSLIQ SAQTLGIFQI ESPGQRELVG KLTPETFTDL IIDISLFRPG PVKSDMITPF LNARQGFKTR EIFHPDLAEI LSDTQGVVVF HEQVIEIIAT LTGSSLGQAD EKRRALGSRE GQQEVCDWFF AQAISRGYEL KVITQIWDVL RAFASFGFCK AHAAAFALPT YQSAWLKRHY PAAFLAGVLT HEPGMYPKRL LLDEARRNGL TIAPLDINHS DISYRVEGDN QRSIRLSLSD ISGISSVEIS AIIANRPYLD LADFVHRSSV SRPTSEALLM VGAFDRLYGA EINRRDLLLH LNDLYKWSGG SRTKVVTGSQ LSLGFTPTLS KTGLPDLEDH ELVRNEVKYL GMDISHHMIE FYADFLNQIG AIKSNQLLEQ RSGSLVLVAG VKVALQTPPV RSGKRVIFLT LDDGYGCSDA TFFEDAQHSY AEVLYNSQLL LIRGATRRTG LRGISLRAIG AWDLSAAYQK WRSLAICE //