ID A0A0P0VD52_ORYSJ Unreviewed; 1117 AA. AC A0A0P0VD52; DT 26-FEB-2020, integrated into UniProtKB/TrEMBL. DT 26-FEB-2020, sequence version 1. DT 12-AUG-2020, entry version 4. DE RecName: Full=Lactase {ECO:0000256|ARBA:ARBA00017614}; DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756}; GN OrderedLocusNames=Os01g0952600 {ECO:0000313|EMBL:BAF07335.1}; GN ORFNames=OsJ_04784 {ECO:0000313|EMBL:EEE56015.1}, P0431G06.11 GN {ECO:0000313|EMBL:BAD87855.1}; OS Oryza sativa subsp. japonica (Rice). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade; OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa. OX NCBI_TaxID=39947 {ECO:0000313|EMBL:BAD87855.1, ECO:0000313|Proteomes:UP000000763}; RN [1] {ECO:0000313|EMBL:BAD87855.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=12447438; DOI=10.1038/nature01184; RA Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., RA Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., RA Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M., RA Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., RA Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Itoh S., Itoh T., RA Itoh Y., Itoh Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., RA Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., RA Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., RA Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., RA Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., RA Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., RA Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., RA Kim H.I., Eun M.Y., Yano M., Jiang J., Gojobori T.; RT "The genome sequence and structure of rice chromosome 1."; RL Nature 420:312-316(2002). RN [2] {ECO:0000313|EMBL:BAF07335.1, ECO:0000313|Proteomes:UP000000763} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Nipponbare {ECO:0000313|Proteomes:UP000000763}; RX PubMed=16100779; DOI=10.1038/nature03895; RG International rice genome sequencing project (IRGSP); RT "The map-based sequence of the rice genome."; RL Nature 436:793-800(2005). RN [3] {ECO:0000313|EMBL:EEE56015.1, ECO:0000313|Proteomes:UP000007752} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Nipponbare {ECO:0000313|Proteomes:UP000007752}; RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038; RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L., RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., RA Fang L., Lei T., Chen C., Chen H., Xu Z., Li H., Huang H., Zhang F., Xu H., RA Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., RA Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., RA Zheng W., Hao B., Liu S., Wang W., Yuan L., Cao M., McDermott J., RA Samudrala R., Wang J., Wong G.K., Yang H.; RT "The genomes of Oryza sativa: a history of duplications."; RL PLoS Biol. 3:266-281(2005). RN [4] {ECO:0000313|EMBL:BAF07335.1} RP NUCLEOTIDE SEQUENCE. RG IRGSP(International Rice Genome Sequencing Project); RT "Oryza sativa nipponbare(GA3) genomic DNA, chromosome 1."; RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:BAF07335.1} RP NUCLEOTIDE SEQUENCE. RG The Rice Annotation Project (RAP); RT "The Second Rice Annotation Project Meeting (RAP2)."; RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:BAF07335.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=16381971; DOI=10.1093/nar/gkj094; RA Ohyanagi H., Tanaka T., Sakai H., Shigemoto Y., Yamaguchi K., Habara T., RA Fujii Y., Antonio B.A., Nagamura Y., Imanishi T., Ikeo K., Itoh T., RA Gojobori T., Sasaki T.; RT "The Rice Annotation Project Database (RAP-DB): hub for Oryza sativa ssp. RT japonica genome information."; RL Nucleic Acids Res. 34:D741-D744(2006). RN [7] {ECO:0000313|EMBL:BAF07335.1} RP NUCLEOTIDE SEQUENCE. RG The Rice Annotation Project (RAP); RA Itoh T., Tanaka T., Barrero R.A., Yamasaki C., Fujii Y., Hilton P.B., RA Antonio B.A., Aono H., Apweiler R., Bruskiewich R., Bureau T., Burr F., RA Costa de Oliveira A., Fuks G., Habara T., Haberer G., Han B., Harada E., RA Hiraki A.T., Hirochika H., Hoen D., Hokari H., Hosokawa S., Hsing Y., RA Ikawa H., Ikeo K., Imanishi T., Ito Y., Jaiswal P., Kanno M., Kawahara Y., RA Kawamura T., Kawashima H., Khurana J.P., Kikuchi S., Komatsu S., RA Koyanagi K.O., Kubooka H., Lieberherr D., Lin Y.C., Lonsdale D., RA Matsumoto T., Matsuya A., McCombie W.R., Messing J., Miyao A., Mulder N., RA Nagamura Y., Nam J., Namiki N., Numa H., Nurimoto S., O'donovan C., RA Ohyanagi H., Okido T., Oota S., Osato N., Palmer L.E., Quetier F., RA Raghuvanshi S., Saichi N., Sakai H., Sakai Y., Sakata K., Sakurai T., RA Sato F., Sato Y., Schoof H., Seki M., Shibata M., Shimizu Y., Shinozaki K., RA Shinso Y., Singh N.K., Smith-White B., Takeda J., Tanino M., Tatusova T., RA Thongjuea S., Todokoro F., Tsugane M., Tyagi A.K., Vanavichit A., Wang A., RA Wing R.A., Yamaguchi K., Yamamoto M., Yamamoto N., Yu Y., Zhang H., RA Zhao Q., Higo K., Burr B., Gojobori T., Sasaki T.; RT "Curated Genome Annotation of Oryza sativa ssp. japonica and Comparative RT Genome Analysis with Arabidopsis thaliana."; RL Genome Res. 17:175-183(2007). RN [8] {ECO:0000313|EMBL:BAF07335.1} RP NUCLEOTIDE SEQUENCE. RG The Rice Annotation Project (RAP); RA Tanaka T., Antonio B.A., Kikuchi S., Matsumoto T., Nagamura Y., Numa H., RA Sakai H., Wu J., Itoh T., Sasaki T., Aono R., Fujii Y., Habara T., RA Harada E., Kanno M., Kawahara Y., Kawashima H., Kubooka H., Matsuya A., RA Nakaoka H., Saichi N., Sanbonmatsu R., Sato Y., Shinso Y., Suzuki M., RA Takeda J., Tanino M., Todokoro F., Yamaguchi K., Yamamoto N., Yamasaki C., RA Imanishi T., Okido T., Tada M., Ikeo K., Tateno Y., Gojobori T., Lin Y.C., RA Wei F.J., Hsing Y.I., Zhao Q., Han B., Kramer M.R., McCombie R.W., RA Lonsdale D., O'Donovan C.C., Whitfield E.J., Apweiler R., Koyanagi K.O., RA Khurana J.P., Raghuvanshi S., Singh N.K., Tyagi A.K., Haberer G., RA Fujisawa M., Hosokawa S., Ito Y., Ikawa H., Shibata M., Yamamoto M., RA Bruskiewich R.M., Hoen D.R., Bureau TE., Namiki N., Ohyanagi H., Sakai Y., RA Nobushima S., Sakata K., Barrero R.A., Sato Y., Souvorov A., RA Smith-White B., Tatusova T., An S., An G., OOta S., Fuks G., Messing J., RA Christie K.R., Lieberherr D., Kim H., Zuccolo A., Wing R.A., Nobuta K., RA Green P.J., Lu C., Meyers BC., Chaparro C., Piegu B., Panaud O., RA Echeverria M.; RT "The Rice Annotation Project Database (RAP-DB): 2008 update."; RL Nucleic Acids Res. 36:D1028-D1033(2008). RN [9] {ECO:0000313|Proteomes:UP000000763} RP GENOME REANNOTATION. RC STRAIN=cv. Nipponbare {ECO:0000313|Proteomes:UP000000763}; RX PubMed=18089549; DOI=10.1093/nar/gkm978; RG The rice annotation project (RAP); RT "The rice annotation project database (RAP-DB): 2008 update."; RL Nucleic Acids Res. 36:D1028-D1033(2008). RN [10] {ECO:0000313|EMBL:EEE56015.1} RP NUCLEOTIDE SEQUENCE. RA Wang J., Li R., Fan W., Huang Q., Zhang J., Zhou Y., Hu Y., Zi S., Li J., RA Ni P., Zheng H., Zhang Y., Zhao M., Hao Q., McDermott J., Samudrala R., RA Kristiansen K., Wong G.K.-S.; RT "Improved gene annotation of the rice (Oryza sativa) genomes."; RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues CC in beta-D-galactosides.; EC=3.2.1.23; CC Evidence={ECO:0000256|ARBA:ARBA00001412}; CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family. CC {ECO:0000256|ARBA:ARBA00007401, ECO:0000256|RuleBase:RU361154}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP003683; BAD87855.1; -; Genomic_DNA. DR EMBL; AP008207; BAF07335.1; -; Genomic_DNA. DR EMBL; CM000138; EEE56015.1; -; Genomic_DNA. DR RefSeq; XP_015620054.1; XM_015764568.1. DR SMR; A0A0P0VD52; -. DR STRING; 4530.OS01T0952600-01; -. DR CAZy; GH2; Glycoside Hydrolase Family 2. DR GeneID; 4325748; -. DR KEGG; osa:4325748; -. DR KO; K01190; -. DR Proteomes; UP000000763; Chromosome 1. DR Proteomes; UP000007752; Chromosome 1. DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro. DR GO; GO:0004565; F:beta-galactosidase activity; IEA:InterPro. DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro. DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro. DR Gene3D; 2.60.120.260; -; 1. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 2.70.98.10; -; 1. DR InterPro; IPR004199; B-gal_small/dom_5. DR InterPro; IPR036156; Beta-gal/glucu_dom_sf. DR InterPro; IPR011013; Gal_mutarotase_sf_dom. DR InterPro; IPR008979; Galactose-bd-like_sf. DR InterPro; IPR014718; GH-type_carb-bd. DR InterPro; IPR006101; Glyco_hydro_2. DR InterPro; IPR023232; Glyco_hydro_2_AS. DR InterPro; IPR023933; Glyco_hydro_2_beta_Galsidase. DR InterPro; IPR006103; Glyco_hydro_2_cat. DR InterPro; IPR023230; Glyco_hydro_2_CS. DR InterPro; IPR006102; Glyco_hydro_2_Ig-like. DR InterPro; IPR006104; Glyco_hydro_2_N. DR InterPro; IPR017853; Glycoside_hydrolase_SF. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR032312; LacZ_4. DR PANTHER; PTHR46323; PTHR46323; 1. DR Pfam; PF02929; Bgal_small_N; 1. DR Pfam; PF16353; DUF4981; 1. DR Pfam; PF00703; Glyco_hydro_2; 1. DR Pfam; PF02836; Glyco_hydro_2_C; 1. DR Pfam; PF02837; Glyco_hydro_2_N; 1. DR PRINTS; PR00132; GLHYDRLASE2. DR SMART; SM01038; Bgal_small_N; 1. DR SUPFAM; SSF49303; SSF49303; 2. DR SUPFAM; SSF49785; SSF49785; 1. DR SUPFAM; SSF51445; SSF51445; 1. DR SUPFAM; SSF74650; SSF74650; 1. DR PROSITE; PS00719; GLYCOSYL_HYDROL_F2_1; 1. DR PROSITE; PS00608; GLYCOSYL_HYDROL_F2_2; 1. PE 3: Inferred from homology; KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361154}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361154}. FT DOMAIN 805..1099 FT /note="Bgal_small_N" FT /evidence="ECO:0000259|SMART:SM01038" SQ SEQUENCE 1117 AA; 126241 MW; B19894DBEDF76E07 CRC64; MAVASASALF SAKNLPHKPW EDPSFFRWRK REAHVPLRSH DTPEGALKYW HERRNVNYLN SDSAVWNDDA VRGALESAAF WSKGLPYVQT LSGYWKFLLA SSPESVPEKF YDAYFNDSDW EALPVPSNWQ MHGFDRPIYT NVTYPFTMNP PFVPNDNPTG CYRTVFRIPK EWKGRRILLH FEAVDSAFFA WVNGVPVGYS QDSRLPAEFE ITDFCHPCDS EKENVLAVQV MRWSDGSYLE DQDHWWLSGI HRDVLLVSKP QIFITDYFFK ATLDEGFRVA DIEVEVEIDS QKQDREHVST LSIEATLYDN YGPADVLTSD MSAASVANLK LKPASRPKHC YGFHGYVLGG KVENPKLWSS EHPNLYTLVV VLKDSNGKLI ECESCQVGIR NVVLAHKQML VNGCPVVIRG VNRHEHHPRV GKTNLEACMI KDLVLMRQNN INAVRNSHYP QHPRWYELCD IFGLYVIDEA NIETHGFDES SHFKHPTLEP FWASAMLDRV VGMVERDKNH ACIIVWSLGN ESSYGPNHSA MSGWIRGKDP TRPIHYEGGG SRTSSTDIVC PMYMRVWDIL KIAQDPSENR PLILCEYSHA MGNSNGNIDA YWMAIDNTVG LQGGFIWDWV DQGLLKEDAD GSKNWAYGGD FGDTPNDLNF CLNGIVWPDR TIHPAVHEVK YLYQPIKITM MDNMLKIENV HFFETTEALD FSWLLQGDGC ALGSGSLNVP SIAPQSTHLI NMKSSPWFTI WSTCVVKEIF LSINVKLRYQ TQWAKDGHIL ASAQICLPPK KGFVPHAIAL PRSSLVSERV GDHVLISKSN AWQIKVNSIS GTIDSWKVNN IELMSKGIHP CFWRTPTDND KGGFYTKPYV SRWREASLDN ISFYSSQFSL KELPDQTVEI STIYYGLPGN QPKPDETSLS DESESVLFRV QMRGRIYDSG DVILDYEVSP KNDLPPLPRV GVVFNADKSL SRAKWYGRGP FECYPDRKAA AHVGVYESGV DELHVPYIVP GECGGRADVR WVALQDADGF GLFASAYGES PPMQVSASYY GAAELDRATH NHKLVKGDDI EVHLDHKHMG LGGDDSWSPC VHEQYLLPPA RYAFSVRLCP LLPSSSCHDI YHSQLPC //