ID A0A0N9R1Y1_9TELE Unreviewed; 339 AA. AC A0A0N9R1Y1; DT 20-JAN-2016, integrated into UniProtKB/TrEMBL. DT 20-JAN-2016, sequence version 1. DT 16-MAR-2016, entry version 3. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 2 {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00093744}; DE EC=1.6.5.3 {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00093728}; DE Flags: Fragment; GN Name=ND2 {ECO:0000313|EMBL:ALH21935.1}; OS Rhinichthys cataractae (longnose dace). OG Mitochondrion {ECO:0000313|EMBL:ALH21935.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Rhinichthys. OX NCBI_TaxID=340988 {ECO:0000313|EMBL:ALH21935.1}; RN [1] {ECO:0000313|EMBL:ALH21935.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Rcat4 {ECO:0000313|EMBL:ALH21935.1}; RA Taylor E.B., McPhail J.D., Ruskey J.A.; RT "Phylogeography of the longnose dace (Rhinichthys cataractae) species RT group - the Nooksack dace problem."; RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I) that is believed to belong to CC the minimal assembly required for catalysis. Complex I functions CC in the transfer of electrons from NADH to the respiratory chain. CC The immediate electron acceptor for the enzyme is believed to be CC ubiquinone (By similarity). {ECO:0000256|SAAS:SAAS00207298}. CC -!- CATALYTIC ACTIVITY: NADH + ubiquinone + 5 H(+)(In) = NAD(+) + CC ubiquinol + 4 H(+)(Out). {ECO:0000256|RuleBase:RU003403, CC ECO:0000256|SAAS:SAAS00093735}. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00093751}; CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU003403, CC ECO:0000256|SAAS:SAAS00093751}. CC -!- SIMILARITY: Belongs to the complex I subunit 2 family. CC {ECO:0000256|RuleBase:RU003403}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KP744113; ALH21935.1; -; Genomic_DNA. DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro. DR InterPro; IPR010933; NADH_DH_su2_C. DR InterPro; IPR003917; NADH_UbQ_OxRdtase_chain2. DR InterPro; IPR001750; ND/Mrp_mem. DR Pfam; PF06444; NADH_dehy_S2_C; 1. DR Pfam; PF00361; Proton_antipo_M; 1. DR PRINTS; PR01436; NADHDHGNASE2. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|SAAS:SAAS00464461}; KW Membrane {ECO:0000256|SAAS:SAAS00464716, ECO:0000256|SAM:Phobius}; KW Mitochondrion {ECO:0000256|RuleBase:RU000318, KW ECO:0000256|SAAS:SAAS00464403, ECO:0000313|EMBL:ALH21935.1}; KW Mitochondrion inner membrane {ECO:0000256|SAAS:SAAS00464436}; KW NAD {ECO:0000256|RuleBase:RU000317, ECO:0000256|SAAS:SAAS00464384}; KW Oxidoreductase {ECO:0000256|RuleBase:RU000317, KW ECO:0000256|SAAS:SAAS00464503, ECO:0000313|EMBL:ALH21935.1}; KW Respiratory chain {ECO:0000256|SAAS:SAAS00464594}; KW Transmembrane {ECO:0000256|SAAS:SAAS00464491, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00464584, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00464711}; KW Ubiquinone {ECO:0000256|RuleBase:RU000318, KW ECO:0000256|SAAS:SAAS00464648}. FT TRANSMEM 57 80 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 92 113 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 152 171 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 178 196 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 202 219 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 239 257 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 277 298 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 23 287 Proton_antipo_M. {ECO:0000259|Pfam: FT PF00361}. FT DOMAIN 290 333 NADH_dehy_S2_C. {ECO:0000259|Pfam: FT PF06444}. FT NON_TER 339 339 {ECO:0000313|EMBL:ALH21935.1}. SQ SEQUENCE 339 AA; 36655 MW; 15D7C5C840D446F8 CRC64; MNPYVLATLL SSLGLGTTLT FASSHWLLAW MGLEINTLAI IPLMAQHHHP RAVEATTKYF LTQATAAAMI LFASTTNAWI TGGWDMNNMS NPIASAMIVA ALALKIGLAP MHFWMPEVLQ GLDLLTGLIL STWQKLAPLA LIIQTAQAID PLLLTTLGLM STLVGGWGGL NQTQLRKVLA YSSIAHMGWM IIVLQYAPQL TLLALLTYIF MTSAAFLTLK ASSATKIGTL ATIWSKSPIL TTTAALVLLS LGGLPPLTGF MPKWLILQEL AKQDLPLIAT MMALAALLSL YFYLRLCYAM TLTISPNTTT STTPWRSQAT XXSFPLALST VXALGLYPW //