ID A0A0N5CGK9_STREA Unreviewed; 598 AA. AC A0A0N5CGK9; DT 09-DEC-2015, integrated into UniProtKB/TrEMBL. DT 09-DEC-2015, sequence version 1. DT 29-MAY-2024, entry version 25. DE SubName: Full=SH2 domain-containing protein {ECO:0000313|WBParaSite:SPAL_0001698500.1}; OS Strongyloides papillosus (Intestinal threadworm). OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae; OC Strongyloides. OX NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0001698500.1}; RN [1] {ECO:0000313|WBParaSite:SPAL_0001698500.1} RP IDENTIFICATION. RG WormBaseParasite; RL Submitted (FEB-2017) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; A0A0N5CGK9; -. DR STRING; 174720.A0A0N5CGK9; -. DR WBParaSite; SPAL_0001698500.1; SPAL_0001698500.1; SPAL_0001698500. DR Proteomes; UP000046392; Unplaced. DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter. DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter. DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:TreeGrafter. DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter. DR Gene3D; 3.30.505.10; SH2 domain; 2. DR InterPro; IPR000980; SH2. DR InterPro; IPR036860; SH2_dom_sf. DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1. DR PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1. DR Pfam; PF00017; SH2; 2. DR PRINTS; PR00401; SH2DOMAIN. DR SMART; SM00252; SH2; 2. DR SUPFAM; SSF55550; SH2 domain; 2. DR PROSITE; PS50001; SH2; 2. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}. FT DOMAIN 191..280 FT /note="SH2" FT /evidence="ECO:0000259|PROSITE:PS50001" FT DOMAIN 486..594 FT /note="SH2" FT /evidence="ECO:0000259|PROSITE:PS50001" FT REGION 1..116 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 379..413 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 28..54 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 55..70 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 84..104 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 598 AA; 69699 MW; 507BF48AEDA53444 CRC64; MEKEHINIEG ELEIPVSGDV VQGEDEGENV NDGVKEHPTK GNDNEKSIKE DITEESTQDE SEEDPREGYL QEDSEETGKT ETEEETDDNG VRGRFTYRSD DDEQSDYNPD NELDPDLDFT LAENMRELRL RRRRFEDEIE VQQPDLRHPP ILPKKRDRNM DIIDRLTLAE KEMANKTPKE KTIDELYRRD WYFGDVIKEQ VPVIIKGQPD GVFFIRNSTT PGDFTLNFNC NGELKLIKII IDDDGLCHFQ SHGKRFENIT KLIEYFKTHS LESYNSTLPI FLKDHMSYDK YIAEKNKTRV KHVSVILHEM YGIHTESERI YKRVEKLDIE KSKVHYKGTM LQRNLSQAIG AEIVYREAIE KMKADLHDHP DNVTDLKIVK ALEDNILLQL GRIQELREAQ AMTKEEMREL QKVLMNYDTK KHDLYSRYYT LESQRDGLVE VLLSKEVKNL DIQKGIWEAT SLVDYESLQM SEFFLDVVLP FGVSDWLVID ADKNKATELI QQAIDRNPND ADGIFLIRPS FTKQGCYALS ISVKGHIRHC LVEYSNSQDI EQCGYGFMKS NLYFPSMVDF VKYYYHNSMK DHNPELDVTL KRAALQDS //