ID A0A0N4SV67_MOUSE Unreviewed; 222 AA. AC A0A0N4SV67; DT 09-DEC-2015, integrated into UniProtKB/TrEMBL. DT 09-DEC-2015, sequence version 1. DT 25-APR-2018, entry version 22. DE RecName: Full=Peroxisome proliferator-activated receptor gamma {ECO:0000256|RuleBase:RU364110}; DE Short=PPAR-gamma {ECO:0000256|RuleBase:RU364110}; DE AltName: Full=Nuclear receptor subfamily 1 group C member 3 {ECO:0000256|RuleBase:RU364110}; DE Flags: Fragment; GN Name=Pparg {ECO:0000313|Ensembl:ENSMUSP00000144975, GN ECO:0000313|MGI:MGI:97747}; GN Synonyms=PPARG {ECO:0000256|RuleBase:RU364110}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000144975, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000144975, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000144975, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000144975} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000144975}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- FUNCTION: Nuclear receptor that binds peroxisome proliferators CC such as hypolipidemic drugs and fatty acids. Once activated by a CC ligand, the nuclear receptor binds to DNA specific PPAR response CC elements (PPRE) and modulates the transcription of its target CC genes, such as acyl-CoA oxidase. It therefore controls the CC peroxisomal beta-oxidation pathway of fatty acids. Key regulator CC of adipocyte differentiation and glucose homeostasis. ARF6 acts as CC a key regulator of the tissue-specific adipocyte P2 (aP2) CC enhancer. Acts as a critical regulator of gut homeostasis by CC suppressing NF-kappa-B-mediated proinflammatory responses. Plays a CC role in the regulation of cardiovascular circadian rhythms by CC regulating the transcription of ARNTL/BMAL1 in the blood vessels. CC {ECO:0000256|RuleBase:RU364110}. CC -!- SUBUNIT: Heterodimer with other nuclear receptors. CC {ECO:0000256|RuleBase:RU364110}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU364110}. CC Nucleus {ECO:0000256|PROSITE-ProRule:PRU00407, CC ECO:0000256|RuleBase:RU364110, ECO:0000256|SAAS:SAAS00586772}. CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1 CC subfamily. {ECO:0000256|RuleBase:RU364110}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC153828; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC171970; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR SMR; A0A0N4SV67; -. DR Ensembl; ENSMUST00000205213; ENSMUSP00000144975; ENSMUSG00000000440. DR MGI; MGI:97747; Pparg. DR GeneTree; ENSGT00870000136388; -. DR Reactome; R-MMU-381340; Transcriptional regulation of white adipocyte differentiation. DR Reactome; R-MMU-383280; Nuclear Receptor transcription pathway. DR Proteomes; UP000000589; Chromosome 6. DR Bgee; ENSMUSG00000000440; -. DR ExpressionAtlas; A0A0N4SV67; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro. DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule. DR Gene3D; 3.30.50.10; -; 1. DR InterPro; IPR003074; 1Cnucl_rcpt. DR InterPro; IPR003077; PPAR-gamma. DR InterPro; IPR022590; PPARgamma_N. DR InterPro; IPR001628; Znf_hrmn_rcpt. DR InterPro; IPR013088; Znf_NHR/GATA. DR Pfam; PF12577; PPARgamma_N; 1. DR Pfam; PF00105; zf-C4; 1. DR PRINTS; PR01288; PROXISOMEPAR. DR PRINTS; PR01291; PROXISOMPAGR. DR PRINTS; PR00047; STROIDFINGER. DR SMART; SM00399; ZnF_C4; 1. DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1. DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1. PE 1: Evidence at protein level; KW Activator {ECO:0000256|RuleBase:RU364110}; KW Biological rhythms {ECO:0000256|RuleBase:RU364110}; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Cytoplasm {ECO:0000256|RuleBase:RU364110}; KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00407, KW ECO:0000256|RuleBase:RU364110, ECO:0000256|SAAS:SAAS00517091}; KW Metal-binding {ECO:0000256|RuleBase:RU364110, KW ECO:0000256|SAAS:SAAS00517128}; KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00407, KW ECO:0000256|RuleBase:RU364110, ECO:0000256|SAAS:SAAS00517080}; KW Proteomics identification {ECO:0000213|EPD:A0A0N4SV67, KW ECO:0000213|PeptideAtlas:A0A0N4SV67}; KW Receptor {ECO:0000256|RuleBase:RU364110}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transcription {ECO:0000256|PROSITE-ProRule:PRU00407, KW ECO:0000256|RuleBase:RU364110, ECO:0000256|SAAS:SAAS00116478}; KW Transcription regulation {ECO:0000256|PROSITE-ProRule:PRU00407, KW ECO:0000256|RuleBase:RU364110, ECO:0000256|SAAS:SAAS00517167}; KW Zinc {ECO:0000256|RuleBase:RU364110, ECO:0000256|SAAS:SAAS00517098}; KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00407, KW ECO:0000256|RuleBase:RU364110, ECO:0000256|SAAS:SAAS00517125}. FT DOMAIN 106 180 Nuclear receptor. {ECO:0000259|PROSITE: FT PS51030}. FT DNA_BIND 106 180 Nuclear receptor. {ECO:0000256|PROSITE- FT ProRule:PRU00407}. FT NON_TER 222 222 {ECO:0000313|Ensembl:ENSMUSP00000144975}. SQ SEQUENCE 222 AA; 25583 MW; 4132BC143EA88EFE CRC64; MVDTEMPFWP TNFGISSVDL SVMEDHSHSF DIKPFTTVDF SSISAPHYED IPFTRADPMV ADYKYDLKLQ EYQSAIKVEP ASPPYYSEKT QLYNRPHEEP SNSLMAIECR VCGDKASGFH YGVHACEGCK GFFRRTIRLK LIYDRCDLNC RIHKKSRNKC QYCRFQKCLA VGMSHNAIRF GRMPQAEKEK LLAEISSDID QLNPESADLR ALAKHLYDSY IK //