ID   A0A0M6L0K7_MOUSE        Unreviewed;       216 AA.
AC   A0A0M6L0K7;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Somatotropin {ECO:0000256|ARBA:ARBA00018367};
DE   AltName: Full=Growth hormone {ECO:0000256|ARBA:ARBA00032367};
GN   Name=Gh {ECO:0000313|MGI:MGI:95707};
GN   Synonyms=Ghb1 {ECO:0000313|EMBL:CDW51414.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:CDW51414.1};
RN   [1] {ECO:0000313|EMBL:CDW51414.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26697363; DOI=10.1016/j.gdata.2015.09.007;
RA   Premzl M.;
RT   "Third party data gene data set of eutherian growth hormone genes.";
RL   Genom Data 6:166-169(2015).
RN   [2] {ECO:0000313|EMBL:CDW51414.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26862561; DOI=10.1016/j.dib.2015.11.056;
RA   Premzl M.;
RT   "Curated eutherian third party data gene data sets.";
RL   Data Brief 6:208-213(2016).
RN   [3] {ECO:0000313|EMBL:CDW51414.1}
RP   NUCLEOTIDE SEQUENCE.
RX   DOI=10.1016/j.genrep.2019.100414;
RA   Premzl M.;
RT   "Eutherian third-party data gene collections.";
RL   Gene Rep 16:100414-100414(2019).
CC   -!- FUNCTION: Plays an important role in growth control. Its major role in
CC       stimulating body growth is to stimulate the liver and other tissues to
CC       secrete IGF-1. It stimulates both the differentiation and proliferation
CC       of myoblasts. It also stimulates amino acid uptake and protein
CC       synthesis in muscle and other tissues. {ECO:0000256|ARBA:ARBA00025313}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC       ECO:0000256|RuleBase:RU003618}.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000256|ARBA:ARBA00008474, ECO:0000256|RuleBase:RU003618}.
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DR   EMBL; LM644167; CDW51414.1; -; mRNA.
DR   RefSeq; NP_032143.1; NM_008117.3.
DR   SMR; A0A0M6L0K7; -.
DR   DNASU; 14599; -.
DR   GeneID; 14599; -.
DR   KEGG; mmu:14599; -.
DR   CTD; 14599; -.
DR   MGI; MGI:95707; Gh.
DR   VEuPathDB; HostDB:ENSMUSG00000020713; -.
DR   OMA; QTAFCFS; -.
DR   OrthoDB; 1190548at2759; -.
DR   PhylomeDB; A0A0M6L0K7; -.
DR   BioGRID-ORCS; 14599; 7 hits in 73 CRISPR screens.
DR   ChiTaRS; Gh; mouse.
DR   Bgee; ENSMUSG00000020713; Expressed in pituitary gland and 116 other tissues.
DR   ExpressionAtlas; A0A0M6L0K7; baseline and differential.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0071469; P:cellular response to alkaline pH; IEA:Ensembl.
DR   GO; GO:0097067; P:cellular response to thyroid hormone stimulus; IEA:Ensembl.
DR   GO; GO:0007565; P:female pregnancy; IEA:Ensembl.
DR   GO; GO:0048286; P:lung alveolus development; IEA:Ensembl.
DR   GO; GO:1901215; P:negative regulation of neuron death; IEA:Ensembl.
DR   GO; GO:0007405; P:neuroblast proliferation; IEA:Ensembl.
DR   GO; GO:0045927; P:positive regulation of growth; IEA:Ensembl.
DR   GO; GO:0050769; P:positive regulation of neurogenesis; IEA:Ensembl.
DR   GO; GO:0090031; P:positive regulation of steroid hormone biosynthetic process; IEA:Ensembl.
DR   GO; GO:0034097; P:response to cytokine; IEA:Ensembl.
DR   GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
DR   GO; GO:0009416; P:response to light stimulus; IEA:Ensembl.
DR   GO; GO:0043434; P:response to peptide hormone; IEA:Ensembl.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Hormone {ECO:0000256|ARBA:ARBA00022702, ECO:0000256|RuleBase:RU003618};
KW   Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..216
FT                   /note="Somatotropin"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014234056"
FT   COILED          131..151
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   216 AA;  24716 MW;  98666A3AE25D65FC CRC64;
     MATDSRTSWL LTVSLLCLLW PQEASAFPAM PLSSLFSNAV LRAQHLHQLA ADTYKEFERA
     YIPEGQRYSI QNAQAAFCFS ETIPAPTGKE EAQQRTDMEL LRFSLLLIQS WLGPVQFLSR
     IFTNSLMFGT SDRVYEKLKD LEEGIQALMQ ELEDGSPRVG QILKQTYDKF DANMRSDDAL
     LKNYGLLSCF KKDLHKAETY LRVMKCRRFV ESSCAF
//