ID A0A0M6L0K7_MOUSE Unreviewed; 216 AA. AC A0A0M6L0K7; DT 09-DEC-2015, integrated into UniProtKB/TrEMBL. DT 09-DEC-2015, sequence version 1. DT 10-FEB-2021, entry version 44. DE RecName: Full=Growth hormone {ECO:0000256|ARBA:ARBA00013427}; DE AltName: Full=Somatotropin {ECO:0000256|ARBA:ARBA00018367}; GN Name=Gh {ECO:0000313|MGI:MGI:95707}; GN Synonyms=Ghb1 {ECO:0000313|EMBL:CDW51414.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:CDW51414.1}; RN [1] {ECO:0000313|EMBL:CDW51414.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26697363; DOI=10.1016/j.gdata.2015.09.007; RA Premzl M.; RT "Third party data gene data set of eutherian growth hormone genes."; RL Genom Data 6:166-169(2015). RN [2] {ECO:0000313|EMBL:CDW51414.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26862561; DOI=10.1016/j.dib.2015.11.056; RA Premzl M.; RT "Curated eutherian third party data gene data sets."; RL Data Brief 6:208-213(2016). RN [3] {ECO:0000313|EMBL:CDW51414.1} RP NUCLEOTIDE SEQUENCE. RX DOI=10.1016/j.genrep.2019.100414; RA Premzl M.; RT "Eutherian third-party data gene collections."; RL Gene Rep 16:100414-100414(2019). CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613, CC ECO:0000256|RuleBase:RU003618}. CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family. CC {ECO:0000256|ARBA:ARBA00008474, ECO:0000256|RuleBase:RU003618}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LM644167; CDW51414.1; -; mRNA. DR RefSeq; NP_032143.1; NM_008117.3. DR SMR; A0A0M6L0K7; -. DR GeneID; 14599; -. DR KEGG; mmu:14599; -. DR CTD; 14599; -. DR MGI; MGI:95707; Gh. DR OMA; CRRFGES; -. DR OrthoDB; 1190548at2759; -. DR BioGRID-ORCS; 14599; 7 hits in 18 CRISPR screens. DR ChiTaRS; Gh; mouse. DR Bgee; ENSMUSG00000020713; Expressed in pituitary gland and 115 other tissues. DR ExpressionAtlas; A0A0M6L0K7; baseline and differential. DR GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:Ensembl. DR GO; GO:0005829; C:cytosol; IEA:Ensembl. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl. DR GO; GO:0005634; C:nucleus; IEA:Ensembl. DR GO; GO:0030141; C:secretory granule; IEA:Ensembl. DR GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro. DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW. DR GO; GO:0071469; P:cellular response to alkaline pH; IEA:Ensembl. DR GO; GO:0097067; P:cellular response to thyroid hormone stimulus; IEA:Ensembl. DR GO; GO:0007565; P:female pregnancy; IEA:Ensembl. DR GO; GO:0048286; P:lung alveolus development; IEA:Ensembl. DR GO; GO:1901215; P:negative regulation of neuron death; IEA:Ensembl. DR GO; GO:0007405; P:neuroblast proliferation; IEA:Ensembl. DR GO; GO:0045927; P:positive regulation of growth; IEA:Ensembl. DR GO; GO:0050769; P:positive regulation of neurogenesis; IEA:Ensembl. DR GO; GO:0090031; P:positive regulation of steroid hormone biosynthetic process; IEA:Ensembl. DR GO; GO:0034097; P:response to cytokine; IEA:Ensembl. DR GO; GO:0032355; P:response to estradiol; IEA:Ensembl. DR GO; GO:0009416; P:response to light stimulus; IEA:Ensembl. DR GO; GO:0043434; P:response to peptide hormone; IEA:Ensembl. DR InterPro; IPR009079; 4_helix_cytokine-like_core. DR InterPro; IPR034975; Somatotropin. DR InterPro; IPR001400; Somatotropin/Prolactin. DR InterPro; IPR018116; Somatotropin_CS. DR PANTHER; PTHR11417; PTHR11417; 1. DR PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1. DR Pfam; PF00103; Hormone_1; 1. DR PRINTS; PR00836; SOMATOTROPIN. DR SUPFAM; SSF47266; SSF47266; 1. DR PROSITE; PS00266; SOMATOTROPIN_1; 1. DR PROSITE; PS00338; SOMATOTROPIN_2; 1. PE 2: Evidence at transcript level; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Hormone {ECO:0000256|ARBA:ARBA00022702, ECO:0000256|RuleBase:RU003618}; KW Secreted {ECO:0000256|ARBA:ARBA00022525}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}. SQ SEQUENCE 216 AA; 24716 MW; 98666A3AE25D65FC CRC64; MATDSRTSWL LTVSLLCLLW PQEASAFPAM PLSSLFSNAV LRAQHLHQLA ADTYKEFERA YIPEGQRYSI QNAQAAFCFS ETIPAPTGKE EAQQRTDMEL LRFSLLLIQS WLGPVQFLSR IFTNSLMFGT SDRVYEKLKD LEEGIQALMQ ELEDGSPRVG QILKQTYDKF DANMRSDDAL LKNYGLLSCF KKDLHKAETY LRVMKCRRFV ESSCAF //