ID A0A0M3RIU9_9FLAO Unreviewed; 487 AA. AC A0A0M3RIU9; DT 09-DEC-2015, integrated into UniProtKB/TrEMBL. DT 09-DEC-2015, sequence version 1. DT 05-OCT-2016, entry version 7. DE RecName: Full=Bifunctional NAD(P)H-hydrate repair enzyme {ECO:0000256|PIRNR:PIRNR017184}; DE AltName: Full=Nicotinamide nucleotide repair protein {ECO:0000256|PIRNR:PIRNR017184}; GN ORFNames=AM608_08180 {ECO:0000313|EMBL:ALC97622.1}; OS Capnocytophaga sp. oral taxon 323. OC Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales; OC Flavobacteriaceae; Capnocytophaga. OX NCBI_TaxID=1705617 {ECO:0000313|EMBL:ALC97622.1}; RN [1] {ECO:0000313|EMBL:ALC97622.1, ECO:0000313|Proteomes:UP000068952} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=F0383 {ECO:0000313|EMBL:ALC97622.1, RC ECO:0000313|Proteomes:UP000068952}; RA Babu N.S., Beckwith C.J., Beseler K.G., Brison A., Carone J.V., RA Caskin T.P., Diamond M., Durham M.E., Foxe J.M., Go M., RA Henderson B.A., Jones I.B., McGettigan J.A., Micheletti S.J., RA Nasrallah M.E., Ortiz D., Piller C.R., Privatt S.R., Schneider S.L., RA Sharp S., Smith T.C., Stanton J.D., Ullery H.E., Wilson R.J., RA Serrano M.G., Buck G., Lee V., Wang Y., Carvalho R., Voegtly L., RA Shi R., Duckworth R., Johnson A., Loviza R., Walstead R., Shah Z., RA Kiflezghi M., Wade K., Ball S.L., Bradley K.W., Asai D.J., RA Bowman C.A., Russell D.A., Pope W.H., Jacobs-Sera D., Hendrix R.W., RA Hatfull G.F.; RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Bifunctional enzyme that catalyzes the epimerization of CC the S- and R-forms of NAD(P)HX and the dehydration of the S-form CC of NAD(P)HX at the expense of ADP, which is converted to AMP. This CC allows the repair of both epimers of NAD(P)HX, a damaged form of CC NAD(P)H that is a result of enzymatic or heat-dependent hydration. CC {ECO:0000256|PIRNR:PIRNR017184}. CC -!- COFACTOR: CC Name=K(+); Xref=ChEBI:CHEBI:29103; CC Evidence={ECO:0000256|PIRNR:PIRNR017184}; CC Note=Binds 1 potassium ion per subunit. CC {ECO:0000256|PIRNR:PIRNR017184}; CC -!- SIMILARITY: In the C-terminal section; belongs to the NnrD/CARKD CC family. {ECO:0000256|PIRNR:PIRNR017184}. CC -!- SIMILARITY: In the N-terminal section; belongs to the NnrE/AIBP CC family. {ECO:0000256|PIRNR:PIRNR017184}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP012589; ALC97622.1; -; Genomic_DNA. DR RefSeq; WP_053581390.1; NZ_CP012589.1. DR KEGG; col:AM608_08180; -. DR Proteomes; UP000068952; Chromosome. DR GO; GO:0052855; F:ADP-dependent NAD(P)H-hydrate dehydratase activity; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW. DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR CDD; cd01171; YXKO-related; 1. DR Gene3D; 3.40.1190.20; -; 1. DR Gene3D; 3.40.50.10260; -; 1. DR HAMAP; MF_01965; NADHX_dehydratase; 1. DR HAMAP; MF_01966; NADHX_epimerase; 1. DR InterPro; IPR017953; Carbohydrate_kinase_pred_CS. DR InterPro; IPR000631; CARKD. DR InterPro; IPR030677; Nnr. DR InterPro; IPR029056; Ribokinase-like. DR InterPro; IPR004443; YjeF_N_dom. DR Pfam; PF01256; Carb_kinase; 1. DR Pfam; PF03853; YjeF_N; 1. DR PIRSF; PIRSF017184; Nnr; 1. DR SUPFAM; SSF53613; SSF53613; 1. DR SUPFAM; SSF64153; SSF64153; 1. DR TIGRFAMs; TIGR00196; yjeF_cterm; 1. DR TIGRFAMs; TIGR00197; yjeF_nterm; 1. DR PROSITE; PS01050; YJEF_C_2; 1. DR PROSITE; PS51383; YJEF_C_3; 1. DR PROSITE; PS51385; YJEF_N; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|PIRNR:PIRNR017184}; KW Complete proteome {ECO:0000313|Proteomes:UP000068952}; KW Isomerase {ECO:0000256|PIRNR:PIRNR017184}; KW Kinase {ECO:0000313|EMBL:ALC97622.1}; KW Lyase {ECO:0000256|PIRNR:PIRNR017184}; KW Metal-binding {ECO:0000256|PIRNR:PIRNR017184}; KW NAD {ECO:0000256|PIRNR:PIRNR017184}; KW NADP {ECO:0000256|PIRNR:PIRNR017184}; KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR017184}; KW Potassium {ECO:0000256|PIRNR:PIRNR017184}; KW Transferase {ECO:0000313|EMBL:ALC97622.1}. FT DOMAIN 9 215 YjeF N-terminal. {ECO:0000259|PROSITE: FT PS51385}. SQ SEQUENCE 487 AA; 53566 MW; FF1828F166302050 CRC64; MKILNTQQMR EADAHTISAE GITSWQLMER AATKLFEWIK EHLPKERTVT VLAGTGNNGG DGLALARMLI ADGWQVNTYL LCFSEHLSPD CQQNKELLEA QGIAIAEIRA EQVNNITFGK IVIDAAFGIG LNRPAPKWIQ QIFGNLNNSN SYILSVDMPS GLPTERIPSP EEIWVHPHQV LTFQTPKLPF FLPSTGCYIR KWEVLNIGLD EHFLKTLHPD FYYLESDIQQ LQRRRAKFSH KGTYGHALLV GGSYGKIGAV VLSGTAVLRA GAGLLTVAIP QCGYNILQTA LPEAMVLTCE EEKHYKTVEI SFTPSAIGVG IGWGTHPETA SALFGLFQQY PDTPFVIDAD ALNILAQHPE QLKTLPKNAI LTPHPKELER LIGKWDDDLH KLTKAKAFAK EHKVILLIKG AYTMMTDGEK YWINSSGNAG MATAGSGDVL TGMLTGLRAQ GYSAVEAACL GVFLHGLQGD RAAKKMGMER LIARDLL //