ID   A0A0M3RIU9_9FLAO        Unreviewed;       487 AA.
AC   A0A0M3RIU9;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   05-OCT-2016, entry version 7.
DE   RecName: Full=Bifunctional NAD(P)H-hydrate repair enzyme {ECO:0000256|PIRNR:PIRNR017184};
DE   AltName: Full=Nicotinamide nucleotide repair protein {ECO:0000256|PIRNR:PIRNR017184};
GN   ORFNames=AM608_08180 {ECO:0000313|EMBL:ALC97622.1};
OS   Capnocytophaga sp. oral taxon 323.
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Capnocytophaga.
OX   NCBI_TaxID=1705617 {ECO:0000313|EMBL:ALC97622.1};
RN   [1] {ECO:0000313|EMBL:ALC97622.1, ECO:0000313|Proteomes:UP000068952}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0383 {ECO:0000313|EMBL:ALC97622.1,
RC   ECO:0000313|Proteomes:UP000068952};
RA   Babu N.S., Beckwith C.J., Beseler K.G., Brison A., Carone J.V.,
RA   Caskin T.P., Diamond M., Durham M.E., Foxe J.M., Go M.,
RA   Henderson B.A., Jones I.B., McGettigan J.A., Micheletti S.J.,
RA   Nasrallah M.E., Ortiz D., Piller C.R., Privatt S.R., Schneider S.L.,
RA   Sharp S., Smith T.C., Stanton J.D., Ullery H.E., Wilson R.J.,
RA   Serrano M.G., Buck G., Lee V., Wang Y., Carvalho R., Voegtly L.,
RA   Shi R., Duckworth R., Johnson A., Loviza R., Walstead R., Shah Z.,
RA   Kiflezghi M., Wade K., Ball S.L., Bradley K.W., Asai D.J.,
RA   Bowman C.A., Russell D.A., Pope W.H., Jacobs-Sera D., Hendrix R.W.,
RA   Hatfull G.F.;
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Bifunctional enzyme that catalyzes the epimerization of
CC       the S- and R-forms of NAD(P)HX and the dehydration of the S-form
CC       of NAD(P)HX at the expense of ADP, which is converted to AMP. This
CC       allows the repair of both epimers of NAD(P)HX, a damaged form of
CC       NAD(P)H that is a result of enzymatic or heat-dependent hydration.
CC       {ECO:0000256|PIRNR:PIRNR017184}.
CC   -!- COFACTOR:
CC       Name=K(+); Xref=ChEBI:CHEBI:29103;
CC         Evidence={ECO:0000256|PIRNR:PIRNR017184};
CC       Note=Binds 1 potassium ion per subunit.
CC       {ECO:0000256|PIRNR:PIRNR017184};
CC   -!- SIMILARITY: In the C-terminal section; belongs to the NnrD/CARKD
CC       family. {ECO:0000256|PIRNR:PIRNR017184}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the NnrE/AIBP
CC       family. {ECO:0000256|PIRNR:PIRNR017184}.
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DR   EMBL; CP012589; ALC97622.1; -; Genomic_DNA.
DR   RefSeq; WP_053581390.1; NZ_CP012589.1.
DR   KEGG; col:AM608_08180; -.
DR   Proteomes; UP000068952; Chromosome.
DR   GO; GO:0052855; F:ADP-dependent NAD(P)H-hydrate dehydratase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd01171; YXKO-related; 1.
DR   Gene3D; 3.40.1190.20; -; 1.
DR   Gene3D; 3.40.50.10260; -; 1.
DR   HAMAP; MF_01965; NADHX_dehydratase; 1.
DR   HAMAP; MF_01966; NADHX_epimerase; 1.
DR   InterPro; IPR017953; Carbohydrate_kinase_pred_CS.
DR   InterPro; IPR000631; CARKD.
DR   InterPro; IPR030677; Nnr.
DR   InterPro; IPR029056; Ribokinase-like.
DR   InterPro; IPR004443; YjeF_N_dom.
DR   Pfam; PF01256; Carb_kinase; 1.
DR   Pfam; PF03853; YjeF_N; 1.
DR   PIRSF; PIRSF017184; Nnr; 1.
DR   SUPFAM; SSF53613; SSF53613; 1.
DR   SUPFAM; SSF64153; SSF64153; 1.
DR   TIGRFAMs; TIGR00196; yjeF_cterm; 1.
DR   TIGRFAMs; TIGR00197; yjeF_nterm; 1.
DR   PROSITE; PS01050; YJEF_C_2; 1.
DR   PROSITE; PS51383; YJEF_C_3; 1.
DR   PROSITE; PS51385; YJEF_N; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR017184};
KW   Complete proteome {ECO:0000313|Proteomes:UP000068952};
KW   Isomerase {ECO:0000256|PIRNR:PIRNR017184};
KW   Kinase {ECO:0000313|EMBL:ALC97622.1};
KW   Lyase {ECO:0000256|PIRNR:PIRNR017184};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR017184};
KW   NAD {ECO:0000256|PIRNR:PIRNR017184};
KW   NADP {ECO:0000256|PIRNR:PIRNR017184};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR017184};
KW   Potassium {ECO:0000256|PIRNR:PIRNR017184};
KW   Transferase {ECO:0000313|EMBL:ALC97622.1}.
FT   DOMAIN        9    215       YjeF N-terminal. {ECO:0000259|PROSITE:
FT                                PS51385}.
SQ   SEQUENCE   487 AA;  53566 MW;  FF1828F166302050 CRC64;
     MKILNTQQMR EADAHTISAE GITSWQLMER AATKLFEWIK EHLPKERTVT VLAGTGNNGG
     DGLALARMLI ADGWQVNTYL LCFSEHLSPD CQQNKELLEA QGIAIAEIRA EQVNNITFGK
     IVIDAAFGIG LNRPAPKWIQ QIFGNLNNSN SYILSVDMPS GLPTERIPSP EEIWVHPHQV
     LTFQTPKLPF FLPSTGCYIR KWEVLNIGLD EHFLKTLHPD FYYLESDIQQ LQRRRAKFSH
     KGTYGHALLV GGSYGKIGAV VLSGTAVLRA GAGLLTVAIP QCGYNILQTA LPEAMVLTCE
     EEKHYKTVEI SFTPSAIGVG IGWGTHPETA SALFGLFQQY PDTPFVIDAD ALNILAQHPE
     QLKTLPKNAI LTPHPKELER LIGKWDDDLH KLTKAKAFAK EHKVILLIKG AYTMMTDGEK
     YWINSSGNAG MATAGSGDVL TGMLTGLRAQ GYSAVEAACL GVFLHGLQGD RAAKKMGMER
     LIARDLL
//