ID A0A0M3LHR2_AMBME Unreviewed; 253 AA. AC A0A0M3LHR2; DT 09-DEC-2015, integrated into UniProtKB/TrEMBL. DT 09-DEC-2015, sequence version 1. DT 27-MAR-2024, entry version 21. DE RecName: Full=Fucosyltransferase {ECO:0000256|RuleBase:RU003832}; DE EC=2.4.1.- {ECO:0000256|RuleBase:RU003832}; DE Flags: Fragment; GN Name=FUT9 {ECO:0000313|EMBL:AIW47104.1}; OS Ambystoma mexicanum (Axolotl). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; OC Batrachia; Caudata; Salamandroidea; Ambystomatidae; Ambystoma. OX NCBI_TaxID=8296 {ECO:0000313|EMBL:AIW47104.1}; RN [1] {ECO:0000313|EMBL:AIW47104.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26385618; RA Shen X.X., Liang D., Chen M.Y., Mao R.L., Wake D.B., Zhang P.; RT "Enlarged Multilocus Dataset Provides Surprisingly Younger Time of Origin RT for the Plethodontidae, the Largest Family of Salamanders."; RL Syst. Biol. 0:0-0(2015). CC -!- CATALYTIC ACTIVITY: CC Reaction=a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl CC derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->4)-[alpha-L- CC fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+); CC Xref=Rhea:RHEA:14257, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, CC ChEBI:CHEBI:58189, ChEBI:CHEBI:133507, ChEBI:CHEBI:137941; CC EC=2.4.1.152; Evidence={ECO:0000256|ARBA:ARBA00029329}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14258; CC Evidence={ECO:0000256|ARBA:ARBA00029329}; CC -!- CATALYTIC ACTIVITY: CC Reaction=a neolactoside nLc4Cer + GDP-beta-L-fucose = a neolactoside CC III(3)-alpha-Fuc-nLc4Cer + GDP + H(+); Xref=Rhea:RHEA:48376, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, CC ChEBI:CHEBI:90376, ChEBI:CHEBI:90379; CC Evidence={ECO:0000256|ARBA:ARBA00036757}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48377; CC Evidence={ECO:0000256|ARBA:ARBA00036757}; CC -!- CATALYTIC ACTIVITY: CC Reaction=alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl- CC beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl- CC (1<->1')-ceramide + GDP-beta-L-fucose = a neolactoside IV(3)-alpha- CC Gal,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+); Xref=Rhea:RHEA:48380, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, CC ChEBI:CHEBI:90380, ChEBI:CHEBI:90381; CC Evidence={ECO:0000256|ARBA:ARBA00036053}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48381; CC Evidence={ECO:0000256|ARBA:ARBA00036053}; CC -!- CATALYTIC ACTIVITY: CC Reaction=alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)- CC N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N- CC acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D- CC glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = alpha-N- CC glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta- CC D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl- CC (1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)- CC beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+); Xref=Rhea:RHEA:48388, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, CC ChEBI:CHEBI:90383, ChEBI:CHEBI:90384; CC Evidence={ECO:0000256|ARBA:ARBA00036295}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48389; CC Evidence={ECO:0000256|ARBA:ARBA00036295}; CC -!- CATALYTIC ACTIVITY: CC Reaction=an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)- CC N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an CC alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D- CC GlcNAc derivative + GDP + H(+); Xref=Rhea:RHEA:56076, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, CC ChEBI:CHEBI:136545, ChEBI:CHEBI:139509; CC Evidence={ECO:0000256|ARBA:ARBA00036481}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56077; CC Evidence={ECO:0000256|ARBA:ARBA00036481}; CC -!- CATALYTIC ACTIVITY: CC Reaction=an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc CC derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal- CC (1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+); CC Xref=Rhea:RHEA:77191, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, CC ChEBI:CHEBI:58189, ChEBI:CHEBI:133510, ChEBI:CHEBI:195560; CC Evidence={ECO:0000256|ARBA:ARBA00043838}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77192; CC Evidence={ECO:0000256|ARBA:ARBA00043838}; CC -!- CATALYTIC ACTIVITY: CC Reaction=an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)- CC beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an CC alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D- CC Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + CC H(+); Xref=Rhea:RHEA:68044, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, CC ChEBI:CHEBI:58189, ChEBI:CHEBI:145343, ChEBI:CHEBI:176900; CC Evidence={ECO:0000256|ARBA:ARBA00036234}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68045; CC Evidence={ECO:0000256|ARBA:ARBA00036234}; CC -!- CATALYTIC ACTIVITY: CC Reaction=beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc CC + GDP-beta-L-fucose = beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D- CC GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+); CC Xref=Rhea:RHEA:77187, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, CC ChEBI:CHEBI:58189, ChEBI:CHEBI:60239, ChEBI:CHEBI:61352; CC Evidence={ECO:0000256|ARBA:ARBA00043828}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77188; CC Evidence={ECO:0000256|ARBA:ARBA00043828}; CC -!- PATHWAY: Glycolipid biosynthesis. {ECO:0000256|ARBA:ARBA00004934}. CC -!- PATHWAY: Protein modification; protein glycosylation. CC {ECO:0000256|ARBA:ARBA00004922}. CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}. CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane CC {ECO:0000256|ARBA:ARBA00004394}. Golgi apparatus, Golgi stack membrane CC {ECO:0000256|RuleBase:RU003832}; Single-pass type II membrane protein CC {ECO:0000256|RuleBase:RU003832}. Golgi apparatus, trans-Golgi network CC membrane {ECO:0000256|ARBA:ARBA00037848}; Single-pass type II membrane CC protein {ECO:0000256|ARBA:ARBA00037848}. Membrane CC {ECO:0000256|ARBA:ARBA00004370}. CC -!- SIMILARITY: Belongs to the glycosyltransferase 10 family. CC {ECO:0000256|ARBA:ARBA00008919, ECO:0000256|RuleBase:RU003832}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KF912774; AIW47104.1; -; Genomic_DNA. DR AlphaFoldDB; A0A0M3LHR2; -. DR UniPathway; UPA00378; -. DR GO; GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell. DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. DR GO; GO:0008417; F:fucosyltransferase activity; IEA:InterPro. DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW. DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway. DR Gene3D; 3.40.50.11660; Glycosyl transferase family 10, C-terminal domain; 1. DR InterPro; IPR031481; Glyco_tran_10_N. DR InterPro; IPR001503; Glyco_trans_10. DR InterPro; IPR038577; GT10-like_C_sf. DR PANTHER; PTHR11929:SF10; 4-GALACTOSYL-N-ACETYLGLUCOSAMINIDE 3-ALPHA-L-FUCOSYLTRANSFERASE 9; 1. DR PANTHER; PTHR11929; ALPHA- 1,3 -FUCOSYLTRANSFERASE; 1. DR Pfam; PF17039; Glyco_tran_10_N; 1. DR Pfam; PF00852; Glyco_transf_10; 1. DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1. PE 3: Inferred from homology; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676, KW ECO:0000256|RuleBase:RU003832}; KW Golgi apparatus {ECO:0000256|RuleBase:RU003832}; KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003832}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU003832}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}. FT DOMAIN 1..88 FT /note="Fucosyltransferase N-terminal" FT /evidence="ECO:0000259|Pfam:PF17039" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AIW47104.1" FT NON_TER 253 FT /evidence="ECO:0000313|EMBL:AIW47104.1" SQ SEQUENCE 253 AA; 29749 MW; C676542F120182CB CRC64; CDSLFNIQGC HLTIDRSLYN RSHAVLIHHR DINWDLTNLP QQARPPFQKW IWMNLESPTH TPQKSGIEHL FNLTLTYRRD SDIQVPYGFM IVSTNPLEFD VPSKDKLVCW VVSNWNPDHA RVKYYNELSK YIAIQTYGQA FGDYLNDKSL IPTISTCKFY LSFENSIHKD YITEKLYNAL LAGSVPVVLG PSRENYENYI PADSFIHVDD FLSPRELADY LLMLNEENEM YISLFNWRKY YTVNVSQFWE SHA //