ID   A0A0M3AJB2_9SPHN        Unreviewed;      1115 AA.
AC   A0A0M3AJB2;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   05-DEC-2018, entry version 21.
DE   RecName: Full=Carbamoyl-phosphate synthase large chain {ECO:0000256|HAMAP-Rule:MF_01210};
DE            EC=6.3.5.5 {ECO:0000256|HAMAP-Rule:MF_01210};
DE   AltName: Full=Carbamoyl-phosphate synthetase ammonia chain {ECO:0000256|HAMAP-Rule:MF_01210};
GN   Name=carB {ECO:0000256|HAMAP-Rule:MF_01210};
GN   ORFNames=YP76_21725 {ECO:0000313|EMBL:KKW90068.1};
OS   Sphingobium chungbukense.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingobium.
OX   NCBI_TaxID=56193 {ECO:0000313|EMBL:KKW90068.1, ECO:0000313|Proteomes:UP000033874};
RN   [1] {ECO:0000313|EMBL:KKW90068.1, ECO:0000313|Proteomes:UP000033874}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DJ77 {ECO:0000313|EMBL:KKW90068.1,
RC   ECO:0000313|Proteomes:UP000033874};
RA   Kim Y.-C., Chae J.-C.;
RT   "Genome sequence of aromatic hydrocarbons-degrading Sphingobium
RT   chungbukense DJ77.";
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP +
CC         carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate;
CC         Xref=Rhea:RHEA:18633, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17544, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216, ChEBI:CHEBI:58228,
CC         ChEBI:CHEBI:58359; EC=6.3.5.5; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_01210, ECO:0000256|SAAS:SAAS00383240};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|SAAS:SAAS00981842};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|SAAS:SAAS00611658};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis;
CC       carbamoyl phosphate from bicarbonate: step 1/1.
CC       {ECO:0000256|HAMAP-Rule:MF_01210, ECO:0000256|SAAS:SAAS00981844}.
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC       pathway; (S)-dihydroorotate from bicarbonate: step 1/3.
CC       {ECO:0000256|HAMAP-Rule:MF_01210, ECO:0000256|SAAS:SAAS01000080}.
CC   -!- SUBUNIT: Composed of two chains; the small (or glutamine) chain
CC       promotes the hydrolysis of glutamine to ammonia, which is used by
CC       the large (or ammonia) chain to synthesize carbamoyl phosphate.
CC       {ECO:0000256|HAMAP-Rule:MF_01210, ECO:0000256|SAAS:SAAS00570548}.
CC   -!- SIMILARITY: Belongs to the CarB family. {ECO:0000256|HAMAP-
CC       Rule:MF_01210, ECO:0000256|SAAS:SAAS00570556}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|HAMAP-Rule:MF_01210}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KKW90068.1}.
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DR   EMBL; LBIC01000012; KKW90068.1; -; Genomic_DNA.
DR   RefSeq; WP_046765689.1; NZ_LBIC01000012.1.
DR   EnsemblBacteria; KKW90068; KKW90068; YP76_21725.
DR   PATRIC; fig|56193.3.peg.4569; -.
DR   UniPathway; UPA00068; UER00171.
DR   UniPathway; UPA00070; UER00115.
DR   Proteomes; UP000033874; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd01424; MGS_CPS_II; 1.
DR   Gene3D; 1.10.1030.10; -; 1.
DR   Gene3D; 3.40.50.1380; -; 1.
DR   HAMAP; MF_01210_A; CPSase_L_chain_A; 1.
DR   HAMAP; MF_01210_B; CPSase_L_chain_B; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR006275; CarbamoylP_synth_lsu.
DR   InterPro; IPR005480; CarbamoylP_synth_lsu_oligo.
DR   InterPro; IPR036897; CarbamoylP_synth_lsu_oligo_sf.
DR   InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR   InterPro; IPR005483; CbamoylP_synth_lsu_CPSase_dom.
DR   InterPro; IPR011607; MGS-like_dom.
DR   InterPro; IPR036914; MGS-like_dom_sf.
DR   InterPro; IPR033937; MGS_CPS_CarB.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   Pfam; PF02786; CPSase_L_D2; 2.
DR   Pfam; PF02787; CPSase_L_D3; 1.
DR   Pfam; PF02142; MGS; 1.
DR   PRINTS; PR00098; CPSASE.
DR   SMART; SM01096; CPSase_L_D3; 1.
DR   SMART; SM00851; MGS; 1.
DR   SUPFAM; SSF48108; SSF48108; 1.
DR   SUPFAM; SSF52335; SSF52335; 1.
DR   SUPFAM; SSF52440; SSF52440; 2.
DR   TIGRFAMs; TIGR01369; CPSaseII_lrg; 1.
DR   PROSITE; PS50975; ATP_GRASP; 2.
DR   PROSITE; PS00866; CPSASE_1; 1.
DR   PROSITE; PS00867; CPSASE_2; 2.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_01210,
KW   ECO:0000256|SAAS:SAAS00981831};
KW   Arginine biosynthesis {ECO:0000256|HAMAP-Rule:MF_01210,
KW   ECO:0000256|SAAS:SAAS00981841};
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_01210, ECO:0000256|PROSITE-
KW   ProRule:PRU00409, ECO:0000256|SAAS:SAAS00710217};
KW   Complete proteome {ECO:0000313|Proteomes:UP000033874};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_01210,
KW   ECO:0000256|SAAS:SAAS00710245};
KW   Magnesium {ECO:0000256|SAAS:SAAS00981805};
KW   Manganese {ECO:0000256|SAAS:SAAS00511130};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00511109};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01210,
KW   ECO:0000256|PROSITE-ProRule:PRU00409, ECO:0000256|SAAS:SAAS00710285};
KW   Pyrimidine biosynthesis {ECO:0000256|HAMAP-Rule:MF_01210,
KW   ECO:0000256|SAAS:SAAS01000143};
KW   Reference proteome {ECO:0000313|Proteomes:UP000033874};
KW   Repeat {ECO:0000256|HAMAP-Rule:MF_01210,
KW   ECO:0000256|SAAS:SAAS00981845}.
FT   DOMAIN      133    328       ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
FT   DOMAIN      714    909       ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
FT   REGION        1    402       Carboxyphosphate synthetic domain.
FT                                {ECO:0000256|HAMAP-Rule:MF_01210}.
FT   REGION      976   1115       Allosteric domain. {ECO:0000256|HAMAP-
FT                                Rule:MF_01210}.
SQ   SEQUENCE   1115 AA;  119967 MW;  C8115F2D77F99920 CRC64;
     MPKRTDISSI LIIGAGPIII GQACEFDYSG TQAVKALKEE GYRIILVNSN PATIMTDPEF
     ADATYVEPIT PEIVAKIIEK ERPDAVLPTM GGQTALNTAL ALFNDGTLEK YGVKMIGADA
     QAIDKAEDRL KFRDAMDKIG LESARSRIAH TMEEAMEALE FTGLPSIIRP SFTLGGTGGG
     VAYNKEEFKR IVSEGLDASP TTEVLIEESL LGWKEYEMEV VRDRNDNAII ICSIENVDPM
     GVHTGDSITV APALTLTDKE YQIMRNASIA VLREIGVETG GSNVQFAVNP KDGRLIVIEM
     NPRVSRSSAL ASKATGFPIA KVAAKLAVGY TLDEIENDIT GATPASFEPT IDYVVTKIPR
     FAFEKFKGSE PLLGTAMKSV GEVMAIGRNI HESMQKALRG LETGLCGFNE VDHLVGAPKD
     DIIAALAQPT PDRLLVAAQA LREGLTVAEI HTIAKFDPWF LERIKEIVDA EAEILANGLP
     QDADGMRRLK SMGFADKRLA YLALKSANLR GMERGIARGS GLIHDAIKAM TGGVTEDEVR
     ALRHKLGVRP VFKRIDTCAA EFEARTPYMY STYEAPIFGE AENEAQPSDR KKVVILGGGP
     NRIGQGIEFD YCCVHACFAL SEAGYETIMV NCNPETVSTD YDTSDRLYFE PLTAEDVLEI
     LSVEMSNGTL AGVIVQFGGQ TPLKLAQALE DAGIPILGTS PDAIDLAEDR ERFAALIDKL
     KLKQPANGIA RSREEAIAVA NRIGYPVLMR PSYVLGGRAM EIVDGQAQLE EYIATAVQVS
     GDSPVLIDQY LRDAVEVDVD ALCDGDDVVV AGVLQHIEEA GVHSGDSACS LPPYSLSDDI
     IAEIERQADV LARALSVRGL MNIQFAVKDG PEGQTVYLIE VNPRASRTVP FVAKAIGTPI
     AKIASRVMAG EKLKNLPKID RNAISHIAVK EAVFPFARFP GVDPVLSPEM KSTGEVMGID
     SDFATAFAKS QLGGGTVLPK SGTVFVSVKD SDKPVILPAV RKMADLGFTI IATGGTARYL
     EEQGIAVHPV NKVAEGRPHI VDKIIDGDVD LIFNTTEGWQ SLKDSKEIRT SALRAKVASF
     TTAAASVAAA DAIEALRGHA LEVRSLQSYY PVSQA
//