ID A0A0L8G1S6_OCTBM Unreviewed; 507 AA. AC A0A0L8G1S6; DT 11-NOV-2015, integrated into UniProtKB/TrEMBL. DT 11-NOV-2015, sequence version 1. DT 30-AUG-2017, entry version 14. DE RecName: Full=Presenilin {ECO:0000256|RuleBase:RU361148}; DE EC=3.4.23.- {ECO:0000256|RuleBase:RU361148}; GN ORFNames=OCBIM_22002682mg {ECO:0000313|EMBL:KOF70540.1}; OS Octopus bimaculoides (California two-spotted octopus). OC Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Cephalopoda; Coleoidea; OC Neocoleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; OC Octopus. OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF70540.1, ECO:0000313|Proteomes:UP000053454}; RN [1] {ECO:0000313|Proteomes:UP000053454} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Albertin C.B., Simakov O., Mitros T., Wang Z.Y., Pungot J.R., RA Edsinger-Gonzalez E., Brenner S., Ragsdale C.W., Rokhsar D.S.; RT "WGS assembly of Octopus bimaculoides."; RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Probable subunit of the gamma-secretase complex, an CC endoprotease complex that catalyzes the intramembrane cleavage of CC integral membrane proteins such as Notch receptors. CC {ECO:0000256|RuleBase:RU361148}. CC -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU361148}. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|RuleBase:RU361148}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU361148}. CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane CC {ECO:0000256|RuleBase:RU361148}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU361148}. CC -!- DOMAIN: The PAL motif is required for normal active site CC conformation. {ECO:0000256|RuleBase:RU361148}. CC -!- SIMILARITY: Belongs to the peptidase A22A family. CC {ECO:0000256|RuleBase:RU361148}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KQ424738; KOF70540.1; -; Genomic_DNA. DR RefSeq; XP_014785182.1; XM_014929696.1. DR EnsemblMetazoa; Ocbimv22002680m; Ocbimv22002680m.p; Ocbimv22002682m.g. DR EnsemblMetazoa; Ocbimv22002681m; Ocbimv22002681m.p; Ocbimv22002682m.g. DR GeneID; 106879938; -. DR Proteomes; UP000053454; Unassembled WGS sequence. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042500; F:aspartic endopeptidase activity, intramembrane cleaving; IEA:InterPro. DR GO; GO:0042987; P:amyloid precursor protein catabolic process; IEA:InterPro. DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro. DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW. DR GO; GO:0016485; P:protein processing; IEA:InterPro. DR InterPro; IPR002031; Pept_A22A_PS1. DR InterPro; IPR001108; Peptidase_A22A. DR InterPro; IPR006639; Preselin/SPP. DR PANTHER; PTHR10202; PTHR10202; 1. DR PANTHER; PTHR10202:SF27; PTHR10202:SF27; 1. DR Pfam; PF01080; Presenilin; 1. DR PRINTS; PR01072; PRESENILIN. DR SMART; SM00730; PSN; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000053454}; KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU361148}; KW Golgi apparatus {ECO:0000256|RuleBase:RU361148}; KW Hydrolase {ECO:0000256|RuleBase:RU361148}; KW Membrane {ECO:0000256|RuleBase:RU361148, KW ECO:0000256|SAAS:SAAS00075475}; KW Notch signaling pathway {ECO:0000256|RuleBase:RU361148}; KW Protease {ECO:0000256|RuleBase:RU361148}; KW Reference proteome {ECO:0000313|Proteomes:UP000053454}; KW Transmembrane {ECO:0000256|RuleBase:RU361148, KW ECO:0000256|SAAS:SAAS00454266}; KW Transmembrane helix {ECO:0000256|RuleBase:RU361148, KW ECO:0000256|SAAS:SAAS00075488}. FT TRANSMEM 103 127 Helical. {ECO:0000256|RuleBase:RU361148}. FT TRANSMEM 154 175 Helical. {ECO:0000256|RuleBase:RU361148}. FT TRANSMEM 182 204 Helical. {ECO:0000256|RuleBase:RU361148}. FT TRANSMEM 216 234 Helical. {ECO:0000256|RuleBase:RU361148}. FT TRANSMEM 241 259 Helical. {ECO:0000256|RuleBase:RU361148}. FT TRANSMEM 447 468 Helical. {ECO:0000256|RuleBase:RU361148}. FT TRANSMEM 474 493 Helical. {ECO:0000256|RuleBase:RU361148}. SQ SEQUENCE 507 AA; 56517 MW; 9141C80BD9FB4CF4 CRC64; MNQSSSDDEP TERTSLLSSP ASSGSPPRNH PNMETYIDAE RTERMNRRGQ RPDIRGIYDN DREAEVDPSE SEVSIPATVA RRKGYSSGTE EEEETLLYGA KHVIMLFVPV TLCMIVVVAT ISSVTYYTQP GGYLIYTPFH EETDDSGTKV WQSFANAFIL LGVIAVMTVV LLLLYKYRCY KVIHGWLIVS SLLLLFMFSY MYLGEVLKAY NAPMDYITVA ILMWNFGVIG MICIHWKGPL LLQQAYLLMI SALMALIFIK YLPDWTTWSV LGIMVFWDLV AVLCPKGPLR VLVETAQHRN EDIFPALIYS STMVWQIVTM ADESPKRDSG ANSTSTLATD VHSSPATNAT SNPEAGTNIY RNDVDAHNLT NSIDSQTARR AIDALGEMEN DPNSEANNRP PADRNQRSQG SGEEEEEERG VKLGLGDFIF YGVLVGKASS YGDWNTTLAC FVAILIGLCF TLLLLAIFRK ALPALPISIT FGLIFNFATR GLVRPFMDNL ASEQMYI //