ID A0A0L7KAP1_PLAFX Unreviewed; 403 AA. AC A0A0L7KAP1; DT 11-NOV-2015, integrated into UniProtKB/TrEMBL. DT 11-NOV-2015, sequence version 1. DT 29-MAY-2024, entry version 34. DE RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119}; DE EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119}; GN ORFNames=PFHG_02210 {ECO:0000313|EMBL:KOB60448.1}; OS Plasmodium falciparum (isolate HB3). OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; OC Plasmodiidae; Plasmodium; Plasmodium (Laverania). OX NCBI_TaxID=137071 {ECO:0000313|EMBL:KOB60448.1, ECO:0000313|Proteomes:UP000054289}; RN [1] {ECO:0000313|EMBL:KOB60448.1, ECO:0000313|Proteomes:UP000054289} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=HB3 {ECO:0000313|EMBL:KOB60448.1}; RG The Broad Institute Genome Sequencing Platform; RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L., RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D., RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D., RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S., RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.; RT "Annotation of Plasmodium falciparum HB3."; RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000054289} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Birren B., Lander E., Galagan J., Nusbaum C., Devon K., Henn M., Jaffe D., RA Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E., RA Brockman W., MacCallum I.A., Rounsley S., Young S., LaButti K., RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R., RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J., RA Kodira C., Zeng Q., Oleary S., Yandava C., Alvarado L., Wirth D., RA Volkman S., Hartl D.; RT "The genome sequence of the Plasmodium falciparum HB3."; RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- CC hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- CC COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; CC EC=2.3.1.225; Evidence={ECO:0000256|RuleBase:RU079119}; CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004477}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity. CC {ECO:0000256|RuleBase:RU079119}. CC -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family. CC {ECO:0000256|RuleBase:RU079119}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|RuleBase:RU079119}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CH671963; KOB60448.1; -; Genomic_DNA. DR AlphaFoldDB; A0A0L7KAP1; -. DR EnsemblProtists; KOB60448; KOB60448; PFHG_02210. DR OMA; YIGYVTT; -. DR Proteomes; UP000054289; Unassembled WGS sequence. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005794; C:Golgi apparatus; IEA:TreeGrafter. DR GO; GO:0004177; F:aminopeptidase activity; IEA:InterPro. DR GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0006612; P:protein targeting to membrane; IEA:TreeGrafter. DR GO; GO:0006508; P:proteolysis; IEA:InterPro. DR Gene3D; 3.40.630.10; Zn peptidases; 1. DR InterPro; IPR001594; Palmitoyltrfase_DHHC. DR InterPro; IPR001948; Peptidase_M18. DR PANTHER; PTHR22883:SF286; PALMITOYLTRANSFERASE ZDHHC4; 1. DR PANTHER; PTHR22883; ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN; 1. DR Pfam; PF01529; DHHC; 1. DR Pfam; PF02127; Peptidase_M18; 1. DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1. DR PROSITE; PS50216; DHHC; 1. PE 3: Inferred from homology; KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315, KW ECO:0000256|RuleBase:RU079119}; KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824}; KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU079119}; KW Reference proteome {ECO:0000313|Proteomes:UP000054289}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU079119}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU079119}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU079119}. FT TRANSMEM 276..303 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU079119" FT DOMAIN 231..305 FT /note="Palmitoyltransferase DHHC" FT /evidence="ECO:0000259|Pfam:PF01529" SQ SEQUENCE 403 AA; 47855 MW; 86424170C1ED76BD CRC64; MPSFYIGYVT TCPTNYIETD QNIQLKNFVK QKKYNNTKED HNNNNLKYDT YNKLSYFSTN DSGTSCSFFS SSTSECSTDE LRSLTILHHK KKNTIITERY ITSSLNKETD ENTQNVDTNI INIKKFNKLN MFKINITKNH IVVLYKKKVP YYKPLYLRNI NYIFINSNGK LKYTKKRTPN MFISNNNIKL NKINKHDIIF YKNIKEKEKN KNNHIFYLYR NKLYQYNIPL PYCKICDVYQ ILRSKHCQMC KRCVRTFDHH CPWINNCVAE NNRSFFLLYL YFELFTIWCS IKFISHVVYL TLYDDNGMDK KAREYAQDAL KFIPRSGSNF LACKNLKERL ENNGFINLSE GETWNLNKNE GYVLCKENRN IWGFFVGKNF IIDTGSILIS IGHIDSCALK YHQ //