ID A0A0L0BVI2_LUCCU Unreviewed; 232 AA. AC A0A0L0BVI2; DT 11-NOV-2015, integrated into UniProtKB/TrEMBL. DT 11-NOV-2015, sequence version 1. DT 27-SEP-2017, entry version 8. DE RecName: Full=SAGA-associated factor 11 homolog {ECO:0000256|HAMAP-Rule:MF_03047}; GN Name=Sgf11 {ECO:0000256|HAMAP-Rule:MF_03047}; GN ORFNames=FF38_11604 {ECO:0000313|EMBL:KNC23993.1}; OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Oestroidea; Calliphoridae; Luciliinae; Lucilia. OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC23993.1, ECO:0000313|Proteomes:UP000037069}; RN [1] {ECO:0000313|EMBL:KNC23993.1, ECO:0000313|Proteomes:UP000037069} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=LS {ECO:0000313|EMBL:KNC23993.1, RC ECO:0000313|Proteomes:UP000037069}; RC TISSUE=Full body {ECO:0000313|EMBL:KNC23993.1}; RX PubMed=26108605; DOI=10.1038/ncomms8344; RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., RA Murali S.C., Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., RA Ansell B.R., Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., RA Chao H., Dinh H., Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., RA Ioannidis P., Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., RA Kotze A.C., Gibbs R.A., Richards S., Batterham P., Gasser R.B.; RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin RT future interventions."; RL Nat. Commun. 6:7344-7344(2015). CC -!- FUNCTION: Component of the transcription regulatory histone CC acetylation (HAT) complex SAGA, a multiprotein complex that CC activates transcription by remodeling chromatin and mediating CC histone acetylation and deubiquitination. Within the SAGA complex, CC participates in a subcomplex that specifically deubiquitinates CC histone H2B. The SAGA complex is recruited to specific gene CC promoters by activators, where it is required for transcription. CC {ECO:0000256|HAMAP-Rule:MF_03047, ECO:0000256|RuleBase:RU261113}. CC -!- SUBUNIT: Component of some SAGA transcription coactivator-HAT CC complexes. Within the SAGA complex, participates to a subcomplex CC of SAGA called the DUB module (deubiquitination module). CC {ECO:0000256|HAMAP-Rule:MF_03047}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|HAMAP-Rule:MF_03047, CC ECO:0000256|RuleBase:RU261113}. CC -!- DOMAIN: The C-terminal SGF11-type zinc-finger domain forms part of CC the 'catalytic lobe' of the SAGA deubiquitination module. CC {ECO:0000256|HAMAP-Rule:MF_03047}. CC -!- DOMAIN: The long N-terminal helix forms part of the 'assembly CC lobe' of the SAGA deubiquitination module. {ECO:0000256|HAMAP- CC Rule:MF_03047}. CC -!- SIMILARITY: Belongs to the SGF11 family. {ECO:0000256|HAMAP- CC Rule:MF_03047, ECO:0000256|RuleBase:RU261113}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KNC23993.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JRES01001278; KNC23993.1; -; Genomic_DNA. DR EnsemblMetazoa; KNC23993; KNC23993; FF38_11604. DR OMA; NETHHLR; -. DR Proteomes; UP000037069; Unassembled WGS sequence. DR GO; GO:0071819; C:DUBm complex; IEA:UniProtKB-UniRule. DR GO; GO:0000124; C:SAGA complex; IEA:UniProtKB-UniRule. DR GO; GO:0003713; F:transcription coactivator activity; IEA:UniProtKB-UniRule. DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0016578; P:histone deubiquitination; IEA:UniProtKB-UniRule. DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW. DR HAMAP; MF_03047; Sgf11; 1. DR InterPro; IPR013246; SAGA_su_Sgf11. DR Pfam; PF08209; Sgf11; 1. PE 3: Inferred from homology; KW Activator {ECO:0000256|HAMAP-Rule:MF_03047, KW ECO:0000256|RuleBase:RU261113}; KW Chromatin regulator {ECO:0000256|HAMAP-Rule:MF_03047}; KW Complete proteome {ECO:0000313|Proteomes:UP000037069}; KW Metal-binding {ECO:0000256|HAMAP-Rule:MF_03047}; KW Nucleus {ECO:0000256|HAMAP-Rule:MF_03047}; KW Reference proteome {ECO:0000313|Proteomes:UP000037069}; KW Transcription {ECO:0000256|HAMAP-Rule:MF_03047}; KW Transcription regulation {ECO:0000256|HAMAP-Rule:MF_03047}; KW Zinc {ECO:0000256|HAMAP-Rule:MF_03047}; KW Zinc-finger {ECO:0000256|HAMAP-Rule:MF_03047}. FT ZN_FING 139 160 SGF11-type. {ECO:0000256|HAMAP-Rule: FT MF_03047}. SQ SEQUENCE 232 AA; 24990 MW; 0C41E885CC3CC908 CRC64; MSTGAPNNNN AASSNNSGSK TTTNSTSSTK VPAGNEKSNN VTTTTQNANT STAAILKSYR EIIKDPKSLD EAANYLYQTL LDDAIVGVFI EIHHLRKTGN LTALDGVPDE EAETSSFRIV DMPNFDIFGI STAKKPMDCT CPNCDRPVSA ARFAPHLEKC MGMGRISSRI ASRRLATKES NSASSSSSSS YLQTNAGSDD EDDVDWSSEK RRKKSSQNSR NNGSKKNNGK TF //