ID A0A0L0BRT9_LUCCU Unreviewed; 634 AA. AC A0A0L0BRT9; DT 11-NOV-2015, integrated into UniProtKB/TrEMBL. DT 11-NOV-2015, sequence version 1. DT 11-MAY-2016, entry version 5. DE RecName: Full=Sphingomyelin phosphodiesterase {ECO:0000256|PIRNR:PIRNR000948}; DE EC=3.1.4.12 {ECO:0000256|PIRNR:PIRNR000948}; GN ORFNames=FF38_05078 {ECO:0000313|EMBL:KNC22713.1}; OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Oestroidea; Calliphoridae; Luciliinae; Lucilia. OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC22713.1, ECO:0000313|Proteomes:UP000037069}; RN [1] {ECO:0000313|EMBL:KNC22713.1, ECO:0000313|Proteomes:UP000037069} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=LS {ECO:0000313|EMBL:KNC22713.1, RC ECO:0000313|Proteomes:UP000037069}; RC TISSUE=Full body {ECO:0000313|EMBL:KNC22713.1}; RX PubMed=26108605; DOI=10.1038/ncomms8344; RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., RA Murali S.C., Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., RA Ansell B.R., Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., RA Chao H., Dinh H., Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., RA Ioannidis P., Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., RA Kotze A.C., Gibbs R.A., Richards S., Batterham P., Gasser R.B.; RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin RT future interventions."; RL Nat. Commun. 6:7344-7344(2015). CC -!- FUNCTION: Converts sphingomyelin to ceramide. CC {ECO:0000256|PIRNR:PIRNR000948}. CC -!- CATALYTIC ACTIVITY: Sphingomyelin + H(2)O = N-acylsphingosine + CC phosphocholine. {ECO:0000256|PIRNR:PIRNR000948}. CC -!- SIMILARITY: Belongs to the acid sphingomyelinase family. CC {ECO:0000256|PIRNR:PIRNR000948}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KNC22713.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JRES01001458; KNC22713.1; -; Genomic_DNA. DR EnsemblMetazoa; KNC22713; KNC22713; FF38_05078. DR Proteomes; UP000037069; Unassembled WGS sequence. DR GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW. DR GO; GO:0004767; F:sphingomyelin phosphodiesterase activity; IEA:UniProtKB-EC. DR GO; GO:0006685; P:sphingomyelin catabolic process; IEA:InterPro. DR Gene3D; 3.60.21.10; -; 1. DR InterPro; IPR004843; Calcineurin-like_PHP_apaH. DR InterPro; IPR029052; Metallo-depent_PP-like. DR InterPro; IPR011001; Saposin-like. DR InterPro; IPR008139; SaposinB_dom. DR InterPro; IPR011160; Sphingomy_PDE. DR Pfam; PF00149; Metallophos; 1. DR PIRSF; PIRSF000948; Sphingomy_PDE; 1. DR SUPFAM; SSF47862; SSF47862; 1. DR SUPFAM; SSF56300; SSF56300; 1. DR PROSITE; PS50015; SAP_B; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000037069}; KW Glycosidase {ECO:0000256|PIRNR:PIRNR000948}; KW Hydrolase {ECO:0000256|PIRNR:PIRNR000948}; KW Reference proteome {ECO:0000313|Proteomes:UP000037069}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 634 Sphingomyelin phosphodiesterase. FT {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5005535143. FT DOMAIN 91 182 Saposin B-type. {ECO:0000259|PROSITE: FT PS50015}. SQ SEQUENCE 634 AA; 72121 MW; BC8C7F4A6A6CE09B CRC64; MLSKLILLAL LAVAVRGLNL PGVPVDFEQD DETLSAISQD IANKFSEEYV KFLETGVESS ILKQISTQLA KSHTKKDMFT KSIAELHSAD QFVMCTTCRS VANVIVETFR AEDGELNGPN AESTTKKMVL ELCNRFHIQT PEVCSGLVDL NWPILHYIIM NSLADTRSLC GMLPIRFCKV KQNNFNWSVK VDKGKGLLTA PKSDVPQKTE NDLNIVQITD IHFDPDYKVG ASAECEEPLC CRLNPLGGVS ESAKAGYWSD YRYCDAPLHM VENAFDHIKE THKKIDYIYQ TGDIVPHNVW TTSKEGNKAM LTQINDLMIE KFPDVQIFPS VGNHEPHPTN IFGNEDVPAE LSMNWLYEHL WSIWQRWLPD EAKETVLKGG YYTVSPKPGF RIISLNNNDC YIYNWWIYLD GSATSQPQLD WLQKTLLAAE KAGEYVHILA HIPSGESDCW TVWAREYNRI IERYSHIIGG IFGGHTHKDE MNLHYSQNGH AMAIYWNGGS LTSYSFKNPN YRTYDIEPVT YQVVDHHTWI FNVTEANELG ANGTPRWFKE YQFTEFTNDL SPAGIDALFE KMAAEPDVLL QFWKYKMTSA DPLVDAGCNE RCLLSTICHL VRTVYDEPGR CNELKAKLKE SLNY //