ID A0A0K3AYD4_CAEEL Unreviewed; 428 AA. AC A0A0K3AYD4; DT 11-NOV-2015, integrated into UniProtKB/TrEMBL. DT 11-NOV-2015, sequence version 1. DT 29-MAY-2024, entry version 42. DE RecName: Full=protein xylosyltransferase {ECO:0000256|ARBA:ARBA00011972}; DE EC=2.4.2.26 {ECO:0000256|ARBA:ARBA00011972}; DE AltName: Full=Peptide O-xylosyltransferase {ECO:0000256|ARBA:ARBA00042865}; GN Name=sqv-6 {ECO:0000313|EMBL:CTQ86978.1, GN ECO:0000313|WormBase:Y50D4C.4b}; GN ORFNames=CELE_Y50D4C.4 {ECO:0000313|EMBL:CTQ86978.1}, Y50D4C.4 GN {ECO:0000313|WormBase:Y50D4C.4b}; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; OC Caenorhabditis. OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CTQ86978.1, ECO:0000313|Proteomes:UP000001940}; RN [1] {ECO:0000313|EMBL:CTQ86978.1, ECO:0000313|Proteomes:UP000001940} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CTQ86978.1, RC ECO:0000313|Proteomes:UP000001940}; RX PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RA Sulson J.E., Waterston R.; RT "Genome sequence of the nematode C. elegans: a platform for investigating RT biology."; RL Science 282:2012-2018(1998). CC -!- CATALYTIC ACTIVITY: CC Reaction=L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)- CC L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:50192, Rhea:RHEA- CC COMP:9863, Rhea:RHEA-COMP:12567, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:29999, ChEBI:CHEBI:57632, ChEBI:CHEBI:58223, CC ChEBI:CHEBI:132085; EC=2.4.2.26; CC Evidence={ECO:0000256|ARBA:ARBA00001814}; CC -!- PATHWAY: Glycan metabolism; chondroitin sulfate biosynthesis. CC {ECO:0000256|ARBA:ARBA00004840}. CC -!- PATHWAY: Glycan metabolism; heparan sulfate biosynthesis. CC {ECO:0000256|ARBA:ARBA00005093}. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein CC {ECO:0000256|ARBA:ARBA00004648}. Golgi apparatus membrane CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein CC {ECO:0000256|ARBA:ARBA00004323}. Membrane CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein CC {ECO:0000256|ARBA:ARBA00004606}. CC -!- SIMILARITY: Belongs to the glycosyltransferase 14 family. XylT CC subfamily. {ECO:0000256|ARBA:ARBA00010195}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX284605; CTQ86978.1; -; Genomic_DNA. DR RefSeq; NP_001300279.1; NM_001313350.1. DR AlphaFoldDB; A0A0K3AYD4; -. DR SMR; A0A0K3AYD4; -. DR EnsemblMetazoa; Y50D4C.4b.1; Y50D4C.4b.1; WBGene00005024. DR GeneID; 190099; -. DR AGR; WB:WBGene00005024; -. DR CTD; 190099; -. DR WormBase; Y50D4C.4b; CE50778; WBGene00005024; sqv-6. DR OrthoDB; 4166917at2759; -. DR UniPathway; UPA00755; -. DR UniPathway; UPA00756; -. DR Proteomes; UP000001940; Chromosome V. DR Bgee; WBGene00005024; Expressed in adult organism and 3 other cell types or tissues. DR ExpressionAtlas; A0A0K3AYD4; baseline and differential. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0030158; F:protein xylosyltransferase activity; IEA:UniProtKB-EC. DR GO; GO:0030206; P:chondroitin sulfate biosynthetic process; IEA:UniProtKB-UniPathway. DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:UniProtKB-UniPathway. DR InterPro; IPR003406; Glyco_trans_14. DR InterPro; IPR043538; XYLT. DR PANTHER; PTHR46025; XYLOSYLTRANSFERASE OXT; 1. DR PANTHER; PTHR46025:SF3; XYLOSYLTRANSFERASE OXT; 1. DR Pfam; PF02485; Branch; 1. PE 1: Evidence at protein level; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Proteomics identification {ECO:0007829|EPD:A0A0K3AYD4, KW ECO:0007829|PeptideAtlas:A0A0K3AYD4}; KW Reference proteome {ECO:0000313|Proteomes:UP000001940}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}. SQ SEQUENCE 428 AA; 49630 MW; B319846B0EB35680 CRC64; MFRIGKREFP QNLRIDGGSD WVGIHRNLAE FSISDEELPR KLRKTYESIL LPLESFYHTL AFNSEFCDDL LMSNLRLTNW YRKQGCRCAS LKPIVDWCGC SPLVFREETM KKFELQKAIS KPTYFARKFD SMVDIDSIEA AEMQSISPEK LQLNHPTYHF AFANIFKTGI DEQKLHFESL ANFALKSTET RAKFRKVLRI DALRAHHNAL IEIVMKIETT DGATFEFLIH RLSHVNLTEN EEKLVEHGYL LRAVSFGTKF EWKEELCREY MGFVTDNDTL HTRLQWHPTE HVKKVGDKTS PEMIFKYRKG DELIEQTVVK PYDSVFGGQF DSWNVGKKLS NLTTCSNFFV DIISPSSPDD APPLATLHFP VYTDQNAHCH VDYLRQFFKI ADFCTSGDAC KEKIWSTSYP DPKSDIFVGY DEDTQTLI //