ID A0A0K3AYD4_CAEEL Unreviewed; 428 AA. AC A0A0K3AYD4; DT 11-NOV-2015, integrated into UniProtKB/TrEMBL. DT 11-NOV-2015, sequence version 1. DT 12-AUG-2020, entry version 28. DE RecName: Full=Protein xylosyltransferase {ECO:0000256|ARBA:ARBA00011972}; DE EC=2.4.2.26 {ECO:0000256|ARBA:ARBA00011972}; GN Name=sqv-6 {ECO:0000313|EMBL:CTQ86978.1, GN ECO:0000313|WormBase:Y50D4C.4b}; GN ORFNames=CELE_Y50D4C.4 {ECO:0000313|EMBL:CTQ86978.1}, Y50D4C.4 GN {ECO:0000313|WormBase:Y50D4C.4b}; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; OC Caenorhabditis. OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CTQ86978.1, ECO:0000313|Proteomes:UP000001940}; RN [1] {ECO:0000313|EMBL:CTQ86978.1, ECO:0000313|Proteomes:UP000001940} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CTQ86978.1, RC ECO:0000313|Proteomes:UP000001940}; RX PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RA Sulson J.E., Waterston R.; RT "Genome sequence of the nematode C. elegans: a platform for investigating RT biology."; RL Science 282:2012-2018(1998). CC -!- CATALYTIC ACTIVITY: CC Reaction=L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)- CC L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:50192, Rhea:RHEA- CC COMP:9863, Rhea:RHEA-COMP:12567, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:29999, ChEBI:CHEBI:57632, ChEBI:CHEBI:58223, CC ChEBI:CHEBI:132085; EC=2.4.2.26; CC Evidence={ECO:0000256|ARBA:ARBA00001814}; CC -!- PATHWAY: Glycan metabolism; heparan sulfate biosynthesis. CC {ECO:0000256|ARBA:ARBA00005093}. CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein CC {ECO:0000256|ARBA:ARBA00004323}. Membrane CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein CC {ECO:0000256|ARBA:ARBA00004606}. CC -!- SIMILARITY: Belongs to the glycosyltransferase 14 family. XylT CC subfamily. {ECO:0000256|ARBA:ARBA00010195}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX284605; CTQ86978.1; -; Genomic_DNA. DR RefSeq; NP_001300279.1; NM_001313350.1. DR EnsemblMetazoa; Y50D4C.4b.1; Y50D4C.4b.1; WBGene00005024. DR GeneID; 190099; -. DR CTD; 190099; -. DR WormBase; Y50D4C.4b; CE50778; WBGene00005024; sqv-6. DR GeneTree; ENSGT00940000169133; -. DR UniPathway; UPA00756; -. DR Proteomes; UP000001940; Chromosome V. DR ExpressionAtlas; A0A0K3AYD4; baseline and differential. DR GO; GO:0016020; C:membrane; IEA:InterPro. DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW. DR InterPro; IPR003406; Glyco_trans_14. DR InterPro; IPR043538; XYLT. DR PANTHER; PTHR46025; PTHR46025; 1. DR Pfam; PF02485; Branch; 1. PE 1: Evidence at protein level; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Proteomics identification {ECO:0000213|EPD:A0A0K3AYD4, KW ECO:0000213|PeptideAtlas:A0A0K3AYD4}; KW Reference proteome {ECO:0000313|Proteomes:UP000001940}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CTQ86978.1}. SQ SEQUENCE 428 AA; 49630 MW; B319846B0EB35680 CRC64; MFRIGKREFP QNLRIDGGSD WVGIHRNLAE FSISDEELPR KLRKTYESIL LPLESFYHTL AFNSEFCDDL LMSNLRLTNW YRKQGCRCAS LKPIVDWCGC SPLVFREETM KKFELQKAIS KPTYFARKFD SMVDIDSIEA AEMQSISPEK LQLNHPTYHF AFANIFKTGI DEQKLHFESL ANFALKSTET RAKFRKVLRI DALRAHHNAL IEIVMKIETT DGATFEFLIH RLSHVNLTEN EEKLVEHGYL LRAVSFGTKF EWKEELCREY MGFVTDNDTL HTRLQWHPTE HVKKVGDKTS PEMIFKYRKG DELIEQTVVK PYDSVFGGQF DSWNVGKKLS NLTTCSNFFV DIISPSSPDD APPLATLHFP VYTDQNAHCH VDYLRQFFKI ADFCTSGDAC KEKIWSTSYP DPKSDIFVGY DEDTQTLI //