ID A0A0K3AUY1_CAEEL Unreviewed; 1928 AA. AC A0A0K3AUY1; DT 11-NOV-2015, integrated into UniProtKB/TrEMBL. DT 11-NOV-2015, sequence version 1. DT 10-FEB-2021, entry version 38. DE RecName: Full=Receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902}; DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902}; GN Name=daf-2 {ECO:0000313|EMBL:CTQ86616.1, GN ECO:0000313|WormBase:Y55D5A.5c}; GN ORFNames=CELE_Y55D5A.5 {ECO:0000313|EMBL:CTQ86616.1}, Y55D5A.5 GN {ECO:0000313|WormBase:Y55D5A.5c}; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; OC Caenorhabditis. OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CTQ86616.1, ECO:0000313|Proteomes:UP000001940}; RN [1] {ECO:0000313|EMBL:CTQ86616.1, ECO:0000313|Proteomes:UP000001940} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CTQ86616.1, RC ECO:0000313|Proteomes:UP000001940}; RX PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RA Sulson J.E., Waterston R.; RT "Genome sequence of the nematode C. elegans: a platform for investigating RT biology."; RL Science 282:2012-2018(1998). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; CC Evidence={ECO:0000256|ARBA:ARBA00001171}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single- CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX284603; CTQ86616.1; -; Genomic_DNA. DR RefSeq; NP_001299916.1; NM_001312987.1. DR EnsemblMetazoa; Y55D5A.5c.1; Y55D5A.5c.1; WBGene00000898. DR EnsemblMetazoa; Y55D5A.5c.2; Y55D5A.5c.2; WBGene00000898. DR GeneID; 175410; -. DR CTD; 175410; -. DR WormBase; Y55D5A.5c; CE50204; WBGene00000898; daf-2. DR GeneTree; ENSGT00940000170078; -. DR OMA; KFRGYAF; -. DR OrthoDB; 223327at2759; -. DR Proteomes; UP000001940; Chromosome III. DR ExpressionAtlas; A0A0K3AUY1; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC. DR CDD; cd00063; FN3; 2. DR CDD; cd00064; FU; 1. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.80.20.20; -; 2. DR InterPro; IPR003961; FN3_dom. DR InterPro; IPR036116; FN3_sf. DR InterPro; IPR006211; Furin-like_Cys-rich_dom. DR InterPro; IPR006212; Furin_repeat. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR000494; Rcpt_L-dom. DR InterPro; IPR036941; Rcpt_L-dom_sf. DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom. DR InterPro; IPR008266; Tyr_kinase_AS. DR InterPro; IPR020635; Tyr_kinase_cat_dom. DR Pfam; PF00757; Furin-like; 1. DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1. DR Pfam; PF01030; Recep_L_domain; 2. DR PRINTS; PR00109; TYRKINASE. DR SMART; SM00060; FN3; 2. DR SMART; SM00219; TyrKc; 1. DR SUPFAM; SSF49265; SSF49265; 2. DR SUPFAM; SSF56112; SSF56112; 1. DR SUPFAM; SSF57184; SSF57184; 1. DR PROSITE; PS50853; FN3; 3. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1. PE 1: Evidence at protein level; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:CTQ86616.1}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Proteomics identification {ECO:0000213|EPD:A0A0K3AUY1, KW ECO:0000213|PeptideAtlas:A0A0K3AUY1}; KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:CTQ86616.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000001940}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137, KW ECO:0000313|EMBL:CTQ86616.1}. FT TRANSMEM 1266..1289 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 775..869 FT /note="Fibronectin type-III" FT /evidence="ECO:0000259|PROSITE:PS50853" FT DOMAIN 1051..1149 FT /note="Fibronectin type-III" FT /evidence="ECO:0000259|PROSITE:PS50853" FT DOMAIN 1159..1261 FT /note="Fibronectin type-III" FT /evidence="ECO:0000259|PROSITE:PS50853" FT DOMAIN 1328..1610 FT /note="Protein kinase" FT /evidence="ECO:0000259|PROSITE:PS50011" FT REGION 941..965 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1800..1824 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1851..1908 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 1011..1031 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 1805..1824 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1851..1879 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1888..1908 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1928 AA; 216242 MW; 6F4B6A19F9483E38 CRC64; MTRMNIVRCR RRHKILENLE EENLGPSCSS TTSTTAATEA LGTTTEDMRL KQQRSSSRAT EHDIVDGNHH DDEHITMRRL RLVKNSRTRR RTTPDSSMDC YEENPPSQKT SINYSWISKK SSMTSLMLLL LFAFVQPCAS IVEKRCGPID IRNRPWDIKP QWSKLGDPNE KDLAGQRMVN CTVVEGSLTI SFVLKHKTKA QEEMHRSLQP RYSQDEFITF PHLREITGTL LVFETEGLVD LRKIFPNLRV IGGRSLIQHY ALIIYRNPDL EIGLDKLSVI RNGGVRIIDN RKLCYTKTID WKHLITSSIN DVVVDNAAEY AVTETGLMCP RGACEEDKGE SKCHYLEEKN QEQGVERVQS CWSNTTCQKS CAYDRLLPTK EIGPGCDANG DRCHDQCVGG CERVNDATAC HACKNVYHKG KCIEKCDAHL YLLLQRRCVT REQCLQLNPV LSNKTVPIKA TAGLCSDKCP DGYQINPDDH RECRKCVGKC EIVCEINHVI DTFPKAQAIR LCNIIDGNLT IEIRGKQDSG MASELKDIFA NIHTITGYLL VRQSSPFISL NMFRNLRRIE AKSLFRNLYA ITVFENPNLK KLFDSTTDLT LDRGTVSIAN NKMLCFKYIK QLMSKLNIPL DPIDQSEGTN GEKAICEDMA INVSITAVNA DSVFFSWPSF NITDIDQRKF LGYELFFKEV PRIDENMTIE EDRSACVDSW QSVFKQYYET SNGEPTPDIF MDIGPRERIR PNTLYAYYVA TQMVLHAGAK NGVSKIGFVR TSYYTPDPPT LALAQVDSDA IHITWEAPLQ PNGDLTHYTI MWRENEVSPY EEAEKFCTDA STPANRQHTK DPKETIVADK PVDIPSSRTV APTLLTMMGH EDQQKTCAAT PGCCSCSAIE ESSEQNKKKR PDPMSAIESS AFENKLLDEV LMPRCDIKND PVGCAMLLLP PEIDDSDVGD DDEEPGGGSE QQQRILRNSE ILKRQKRQIL GRSLGGIHGI RSIGRKEYEQ FADMILDTMR VRRSIEDANR VSEELEKAEN LGKAPKTLGG KKPLIHISKK KPSSSSTTST PAPTIASMYA LTRKPTTVPG TRIRLYEIYE PLPGSWAINV SALALDNSYV IRNLKHYTLY AISLSACQNM TVPGASCSIS HRAGALKRTK HITDIDKVLN ETIEWRFMNN SQQVNVTWDP PTEVNGGIFG YVVKLKSKVD GSIVMTRCVG AKRGYSTRNQ GVLFQNLADG RYFVSVTATS VHGAGPEAES SDPIVVMTPG FFTVEIILGM LLVFLILMSI AGCIIYYYIQ VRYGKKVKAL SDFMQLNPEY CVDNKYNADD WELRQDDVVL GQQCGEGSFG KVYLGTGNNV VSLMGDRFGP CAIKINVDDP ASTENLNYLM EANIMKNFKT NFIVKLYGVI STVQPAMVVM EMMDLGNLRD YLRSKREDEV FNETDCNFFD IIPRDKFHEW AAQICDGMAY LESLKFCHRD LAARNCMINR DETVKIGDFG MARDLFYHDY YKPSGKRMMP VRWMSPESLK DGKFDSKSDV WSFGVVLYEM VTLGAQPYIG LSNDEVLNYI GMARKVIKKP ECCENYWYKV MKMCWRYSPR DRPTFLQLVH LLAAEASPEF RDLSFVLTDN QMILDDSEAL DLDDIDDTDM NDQVVEVAPD VENVEVQSDS ERRNTDSIPL KQFKTIPPIN ATTSHSTISI DETPMKAKQR EGSLDEEYAL MNHSGGPSDA EVRTYAGDGD YVERDVREND VPTRRNTGAS TSSYTGGGPY CLTNRGGSNE RGAGFGEAVR LTDGVGSGHL NDDDYVEKEI SSMDTRRSTG ASSSSYGVPQ TNWSGNRGAT YYTSKAQQAA TAAAAAAAAL QQQQNGGRGD RLTQLPGTGH LQSTRGGQDG DYIETEPKNY RNNGSPSRNG NSRDIFNGRS AFGENEHLIE DNEHHPLV //