ID   A0A0K3AUY1_CAEEL        Unreviewed;      1928 AA.
AC   A0A0K3AUY1;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   26-FEB-2020, entry version 34.
DE   RecName: Full=Receptor protein-tyrosine kinase {ECO:0000256|SAAS:SAAS00593197};
DE            EC=2.7.10.1 {ECO:0000256|SAAS:SAAS00593197};
GN   Name=daf-2 {ECO:0000313|EMBL:CTQ86616.1,
GN   ECO:0000313|WormBase:Y55D5A.5c};
GN   ORFNames=CELE_Y55D5A.5 {ECO:0000313|EMBL:CTQ86616.1}, Y55D5A.5
GN   {ECO:0000313|WormBase:Y55D5A.5c};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CTQ86616.1, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CTQ86616.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CTQ86616.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC         [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC         Evidence={ECO:0000256|SAAS:SAAS01123262};
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DR   EMBL; BX284603; CTQ86616.1; -; Genomic_DNA.
DR   RefSeq; NP_001299916.1; NM_001312987.1.
DR   EnsemblMetazoa; Y55D5A.5c.1; Y55D5A.5c.1; WBGene00000898.
DR   EnsemblMetazoa; Y55D5A.5c.2; Y55D5A.5c.2; WBGene00000898.
DR   GeneID; 175410; -.
DR   CTD; 175410; -.
DR   WormBase; Y55D5A.5c; CE50204; WBGene00000898; daf-2.
DR   GeneTree; ENSGT00940000170078; -.
DR   OMA; KFRGYAF; -.
DR   OrthoDB; 223327at2759; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR   CDD; cd00063; FN3; 2.
DR   CDD; cd00064; FU; 1.
DR   Gene3D; 2.60.40.10; -; 3.
DR   Gene3D; 3.80.20.20; -; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR000494; Rcpt_L-dom.
DR   InterPro; IPR036941; Rcpt_L-dom_sf.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   Pfam; PF00757; Furin-like; 1.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF01030; Recep_L_domain; 2.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00060; FN3; 2.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF49265; SSF49265; 2.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS50853; FN3; 3.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   1: Evidence at protein level;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00245980};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Kinase {ECO:0000256|SAAS:SAAS00594439, ECO:0000313|EMBL:CTQ86616.1};
KW   Membrane {ECO:0000256|SAAS:SAAS00602125, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00244405};
KW   Proteomics identification {ECO:0000213|EPD:A0A0K3AUY1,
KW   ECO:0000213|PeptideAtlas:A0A0K3AUY1};
KW   Receptor {ECO:0000256|SAAS:SAAS00600436, ECO:0000313|EMBL:CTQ86616.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Repeat {ECO:0000256|SAAS:SAAS00786331};
KW   Transferase {ECO:0000256|SAAS:SAAS00595469};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00600943, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00602683,
KW   ECO:0000256|SAM:Phobius};
KW   Tyrosine-protein kinase {ECO:0000256|SAAS:SAAS00594505,
KW   ECO:0000313|EMBL:CTQ86616.1}.
FT   TRANSMEM        1266..1289
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          775..869
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          1051..1149
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          1159..1261
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          1328..1610
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          941..965
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1800..1824
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1851..1908
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1011..1031
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1805..1824
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1851..1879
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1888..1908
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1928 AA;  216242 MW;  6F4B6A19F9483E38 CRC64;
     MTRMNIVRCR RRHKILENLE EENLGPSCSS TTSTTAATEA LGTTTEDMRL KQQRSSSRAT
     EHDIVDGNHH DDEHITMRRL RLVKNSRTRR RTTPDSSMDC YEENPPSQKT SINYSWISKK
     SSMTSLMLLL LFAFVQPCAS IVEKRCGPID IRNRPWDIKP QWSKLGDPNE KDLAGQRMVN
     CTVVEGSLTI SFVLKHKTKA QEEMHRSLQP RYSQDEFITF PHLREITGTL LVFETEGLVD
     LRKIFPNLRV IGGRSLIQHY ALIIYRNPDL EIGLDKLSVI RNGGVRIIDN RKLCYTKTID
     WKHLITSSIN DVVVDNAAEY AVTETGLMCP RGACEEDKGE SKCHYLEEKN QEQGVERVQS
     CWSNTTCQKS CAYDRLLPTK EIGPGCDANG DRCHDQCVGG CERVNDATAC HACKNVYHKG
     KCIEKCDAHL YLLLQRRCVT REQCLQLNPV LSNKTVPIKA TAGLCSDKCP DGYQINPDDH
     RECRKCVGKC EIVCEINHVI DTFPKAQAIR LCNIIDGNLT IEIRGKQDSG MASELKDIFA
     NIHTITGYLL VRQSSPFISL NMFRNLRRIE AKSLFRNLYA ITVFENPNLK KLFDSTTDLT
     LDRGTVSIAN NKMLCFKYIK QLMSKLNIPL DPIDQSEGTN GEKAICEDMA INVSITAVNA
     DSVFFSWPSF NITDIDQRKF LGYELFFKEV PRIDENMTIE EDRSACVDSW QSVFKQYYET
     SNGEPTPDIF MDIGPRERIR PNTLYAYYVA TQMVLHAGAK NGVSKIGFVR TSYYTPDPPT
     LALAQVDSDA IHITWEAPLQ PNGDLTHYTI MWRENEVSPY EEAEKFCTDA STPANRQHTK
     DPKETIVADK PVDIPSSRTV APTLLTMMGH EDQQKTCAAT PGCCSCSAIE ESSEQNKKKR
     PDPMSAIESS AFENKLLDEV LMPRCDIKND PVGCAMLLLP PEIDDSDVGD DDEEPGGGSE
     QQQRILRNSE ILKRQKRQIL GRSLGGIHGI RSIGRKEYEQ FADMILDTMR VRRSIEDANR
     VSEELEKAEN LGKAPKTLGG KKPLIHISKK KPSSSSTTST PAPTIASMYA LTRKPTTVPG
     TRIRLYEIYE PLPGSWAINV SALALDNSYV IRNLKHYTLY AISLSACQNM TVPGASCSIS
     HRAGALKRTK HITDIDKVLN ETIEWRFMNN SQQVNVTWDP PTEVNGGIFG YVVKLKSKVD
     GSIVMTRCVG AKRGYSTRNQ GVLFQNLADG RYFVSVTATS VHGAGPEAES SDPIVVMTPG
     FFTVEIILGM LLVFLILMSI AGCIIYYYIQ VRYGKKVKAL SDFMQLNPEY CVDNKYNADD
     WELRQDDVVL GQQCGEGSFG KVYLGTGNNV VSLMGDRFGP CAIKINVDDP ASTENLNYLM
     EANIMKNFKT NFIVKLYGVI STVQPAMVVM EMMDLGNLRD YLRSKREDEV FNETDCNFFD
     IIPRDKFHEW AAQICDGMAY LESLKFCHRD LAARNCMINR DETVKIGDFG MARDLFYHDY
     YKPSGKRMMP VRWMSPESLK DGKFDSKSDV WSFGVVLYEM VTLGAQPYIG LSNDEVLNYI
     GMARKVIKKP ECCENYWYKV MKMCWRYSPR DRPTFLQLVH LLAAEASPEF RDLSFVLTDN
     QMILDDSEAL DLDDIDDTDM NDQVVEVAPD VENVEVQSDS ERRNTDSIPL KQFKTIPPIN
     ATTSHSTISI DETPMKAKQR EGSLDEEYAL MNHSGGPSDA EVRTYAGDGD YVERDVREND
     VPTRRNTGAS TSSYTGGGPY CLTNRGGSNE RGAGFGEAVR LTDGVGSGHL NDDDYVEKEI
     SSMDTRRSTG ASSSSYGVPQ TNWSGNRGAT YYTSKAQQAA TAAAAAAAAL QQQQNGGRGD
     RLTQLPGTGH LQSTRGGQDG DYIETEPKNY RNNGSPSRNG NSRDIFNGRS AFGENEHLIE
     DNEHHPLV
//