ID   A0A0K3AUY1_CAEEL        Unreviewed;      1928 AA.
AC   A0A0K3AUY1;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   13-NOV-2019, entry version 32.
DE   RecName: Full=Receptor protein-tyrosine kinase {ECO:0000256|SAAS:SAAS00593197};
DE            EC=2.7.10.1 {ECO:0000256|SAAS:SAAS00593197};
GN   Name=daf-2 {ECO:0000313|EMBL:CTQ86616.1,
GN   ECO:0000313|WormBase:Y55D5A.5c};
GN   ORFNames=CELE_Y55D5A.5 {ECO:0000313|EMBL:CTQ86616.1}, Y55D5A.5
GN   {ECO:0000313|WormBase:Y55D5A.5c};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CTQ86616.1, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CTQ86616.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CTQ86616.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-
CC         tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136,
CC         Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC         EC=2.7.10.1; Evidence={ECO:0000256|SAAS:SAAS01123262};
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DR   EMBL; BX284603; CTQ86616.1; -; Genomic_DNA.
DR   RefSeq; NP_001299916.1; NM_001312987.1.
DR   EnsemblMetazoa; Y55D5A.5c.1; Y55D5A.5c.1; WBGene00000898.
DR   EnsemblMetazoa; Y55D5A.5c.2; Y55D5A.5c.2; WBGene00000898.
DR   GeneID; 175410; -.
DR   CTD; 175410; -.
DR   WormBase; Y55D5A.5c; CE50204; WBGene00000898; daf-2.
DR   GeneTree; ENSGT00940000170078; -.
DR   OMA; KFRGYAF; -.
DR   OrthoDB; 223327at2759; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   ExpressionAtlas; A0A0K3AUY1; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR   CDD; cd00063; FN3; 2.
DR   CDD; cd00064; FU; 1.
DR   Gene3D; 2.60.40.10; -; 3.
DR   Gene3D; 3.80.20.20; -; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR000494; Rcpt_L-dom.
DR   InterPro; IPR036941; Rcpt_L-dom_sf.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   Pfam; PF00757; Furin-like; 1.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF01030; Recep_L_domain; 2.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00060; FN3; 2.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF49265; SSF49265; 2.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS50853; FN3; 3.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   1: Evidence at protein level;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00245980};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001940};
KW   Kinase {ECO:0000256|SAAS:SAAS00594439, ECO:0000313|EMBL:CTQ86616.1};
KW   Membrane {ECO:0000256|SAAS:SAAS00602125, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00244405};
KW   Proteomics identification {ECO:0000213|EPD:A0A0K3AUY1,
KW   ECO:0000213|PeptideAtlas:A0A0K3AUY1};
KW   Receptor {ECO:0000256|SAAS:SAAS00600436, ECO:0000313|EMBL:CTQ86616.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Repeat {ECO:0000256|SAAS:SAAS00786331};
KW   Transferase {ECO:0000256|SAAS:SAAS00595469};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00600943,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00602683,
KW   ECO:0000256|SAM:Phobius};
KW   Tyrosine-protein kinase {ECO:0000256|SAAS:SAAS00594505,
KW   ECO:0000313|EMBL:CTQ86616.1}.
FT   TRANSMEM   1266   1289       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      775    869       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN     1051   1149       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN     1159   1261       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN     1328   1610       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
FT   REGION      941    965       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1800   1824       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1851   1908       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COILED     1011   1031       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS   1805   1824       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1851   1879       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1888   1908       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   1928 AA;  216242 MW;  6F4B6A19F9483E38 CRC64;
     MTRMNIVRCR RRHKILENLE EENLGPSCSS TTSTTAATEA LGTTTEDMRL KQQRSSSRAT
     EHDIVDGNHH DDEHITMRRL RLVKNSRTRR RTTPDSSMDC YEENPPSQKT SINYSWISKK
     SSMTSLMLLL LFAFVQPCAS IVEKRCGPID IRNRPWDIKP QWSKLGDPNE KDLAGQRMVN
     CTVVEGSLTI SFVLKHKTKA QEEMHRSLQP RYSQDEFITF PHLREITGTL LVFETEGLVD
     LRKIFPNLRV IGGRSLIQHY ALIIYRNPDL EIGLDKLSVI RNGGVRIIDN RKLCYTKTID
     WKHLITSSIN DVVVDNAAEY AVTETGLMCP RGACEEDKGE SKCHYLEEKN QEQGVERVQS
     CWSNTTCQKS CAYDRLLPTK EIGPGCDANG DRCHDQCVGG CERVNDATAC HACKNVYHKG
     KCIEKCDAHL YLLLQRRCVT REQCLQLNPV LSNKTVPIKA TAGLCSDKCP DGYQINPDDH
     RECRKCVGKC EIVCEINHVI DTFPKAQAIR LCNIIDGNLT IEIRGKQDSG MASELKDIFA
     NIHTITGYLL VRQSSPFISL NMFRNLRRIE AKSLFRNLYA ITVFENPNLK KLFDSTTDLT
     LDRGTVSIAN NKMLCFKYIK QLMSKLNIPL DPIDQSEGTN GEKAICEDMA INVSITAVNA
     DSVFFSWPSF NITDIDQRKF LGYELFFKEV PRIDENMTIE EDRSACVDSW QSVFKQYYET
     SNGEPTPDIF MDIGPRERIR PNTLYAYYVA TQMVLHAGAK NGVSKIGFVR TSYYTPDPPT
     LALAQVDSDA IHITWEAPLQ PNGDLTHYTI MWRENEVSPY EEAEKFCTDA STPANRQHTK
     DPKETIVADK PVDIPSSRTV APTLLTMMGH EDQQKTCAAT PGCCSCSAIE ESSEQNKKKR
     PDPMSAIESS AFENKLLDEV LMPRCDIKND PVGCAMLLLP PEIDDSDVGD DDEEPGGGSE
     QQQRILRNSE ILKRQKRQIL GRSLGGIHGI RSIGRKEYEQ FADMILDTMR VRRSIEDANR
     VSEELEKAEN LGKAPKTLGG KKPLIHISKK KPSSSSTTST PAPTIASMYA LTRKPTTVPG
     TRIRLYEIYE PLPGSWAINV SALALDNSYV IRNLKHYTLY AISLSACQNM TVPGASCSIS
     HRAGALKRTK HITDIDKVLN ETIEWRFMNN SQQVNVTWDP PTEVNGGIFG YVVKLKSKVD
     GSIVMTRCVG AKRGYSTRNQ GVLFQNLADG RYFVSVTATS VHGAGPEAES SDPIVVMTPG
     FFTVEIILGM LLVFLILMSI AGCIIYYYIQ VRYGKKVKAL SDFMQLNPEY CVDNKYNADD
     WELRQDDVVL GQQCGEGSFG KVYLGTGNNV VSLMGDRFGP CAIKINVDDP ASTENLNYLM
     EANIMKNFKT NFIVKLYGVI STVQPAMVVM EMMDLGNLRD YLRSKREDEV FNETDCNFFD
     IIPRDKFHEW AAQICDGMAY LESLKFCHRD LAARNCMINR DETVKIGDFG MARDLFYHDY
     YKPSGKRMMP VRWMSPESLK DGKFDSKSDV WSFGVVLYEM VTLGAQPYIG LSNDEVLNYI
     GMARKVIKKP ECCENYWYKV MKMCWRYSPR DRPTFLQLVH LLAAEASPEF RDLSFVLTDN
     QMILDDSEAL DLDDIDDTDM NDQVVEVAPD VENVEVQSDS ERRNTDSIPL KQFKTIPPIN
     ATTSHSTISI DETPMKAKQR EGSLDEEYAL MNHSGGPSDA EVRTYAGDGD YVERDVREND
     VPTRRNTGAS TSSYTGGGPY CLTNRGGSNE RGAGFGEAVR LTDGVGSGHL NDDDYVEKEI
     SSMDTRRSTG ASSSSYGVPQ TNWSGNRGAT YYTSKAQQAA TAAAAAAAAL QQQQNGGRGD
     RLTQLPGTGH LQSTRGGQDG DYIETEPKNY RNNGSPSRNG NSRDIFNGRS AFGENEHLIE
     DNEHHPLV
//