ID A0A0K2JTJ0_9GAMM Unreviewed; 140 AA. AC A0A0K2JTJ0; DT 11-NOV-2015, integrated into UniProtKB/TrEMBL. DT 11-NOV-2015, sequence version 1. DT 24-JAN-2024, entry version 36. DE RecName: Full=Ferric uptake regulation protein {ECO:0000256|ARBA:ARBA00020910, ECO:0000256|RuleBase:RU364037}; GN Name=fur {ECO:0000256|RuleBase:RU364037}; GN ORFNames=FSC845_02575 {ECO:0000313|EMBL:ANH78153.1}; OS Francisella persica ATCC VR-331. OC Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales; OC Francisellaceae; Francisella. OX NCBI_TaxID=1086726 {ECO:0000313|EMBL:ANH78153.1, ECO:0000313|Proteomes:UP000243134}; RN [1] {ECO:0000313|EMBL:ANH78153.1, ECO:0000313|Proteomes:UP000243134} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC VR-331 {ECO:0000313|EMBL:ANH78153.1, RC ECO:0000313|Proteomes:UP000243134}; RA Sjodin A., Larsson P., Backman S., Macellaro A., Nilsson E., Karlsson E., RA Bystrom M., Ohrman C., Stenberg P., Forsman M.; RT "Wolbacha persica: a misclassified Francisella."; RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases. CC -!- COFACTOR: CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC Evidence={ECO:0000256|PIRSR:PIRSR602481-2}; CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033; CC Evidence={ECO:0000256|PIRSR:PIRSR602481-2}; CC Note=Binds 1 Mn(2+) or Fe(2+) ion per subunit. CC {ECO:0000256|PIRSR:PIRSR602481-2}; CC -!- COFACTOR: CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; CC Evidence={ECO:0000256|PIRSR:PIRSR602481-1}; CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR602481-1}; CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738, CC ECO:0000256|RuleBase:RU364037}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, CC ECO:0000256|RuleBase:RU364037}. CC -!- SIMILARITY: Belongs to the Fur family. {ECO:0000256|ARBA:ARBA00007957, CC ECO:0000256|RuleBase:RU364037}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP013022; ANH78153.1; -; Genomic_DNA. DR RefSeq; WP_064461631.1; NZ_CP013022.1. DR AlphaFoldDB; A0A0K2JTJ0; -. DR STRING; 1086726.FSC845_02575; -. DR KEGG; fper:ACH24_06500; -. DR PATRIC; fig|1086726.6.peg.1644; -. DR OrthoDB; 8659436at2; -. DR Proteomes; UP000243134; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR CDD; cd07153; Fur_like; 1. DR Gene3D; 3.30.1490.190; -; 1. DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1. DR InterPro; IPR002481; FUR. DR InterPro; IPR043135; Fur_C. DR InterPro; IPR036388; WH-like_DNA-bd_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR PANTHER; PTHR33202:SF2; FERRIC UPTAKE REGULATION PROTEIN; 1. DR PANTHER; PTHR33202; ZINC UPTAKE REGULATION PROTEIN; 1. DR Pfam; PF01475; FUR; 1. DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1. PE 3: Inferred from homology; KW Cytoplasm {ECO:0000256|RuleBase:RU364037}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU364037}; KW Iron {ECO:0000256|PIRSR:PIRSR602481-2, ECO:0000256|RuleBase:RU364037}; KW Metal-binding {ECO:0000256|PIRSR:PIRSR602481-1, KW ECO:0000256|RuleBase:RU364037}; Repressor {ECO:0000256|RuleBase:RU364037}; KW Transcription {ECO:0000256|ARBA:ARBA00023163, KW ECO:0000256|RuleBase:RU364037}; KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, KW ECO:0000256|RuleBase:RU364037}; KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRSR:PIRSR602481-1}. FT BINDING 87 FT /ligand="Fe cation" FT /ligand_id="ChEBI:CHEBI:24875" FT /evidence="ECO:0000256|PIRSR:PIRSR602481-2" FT BINDING 89 FT /ligand="Fe cation" FT /ligand_id="ChEBI:CHEBI:24875" FT /evidence="ECO:0000256|PIRSR:PIRSR602481-2" FT BINDING 93 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000256|PIRSR:PIRSR602481-1" FT BINDING 96 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000256|PIRSR:PIRSR602481-1" FT BINDING 108 FT /ligand="Fe cation" FT /ligand_id="ChEBI:CHEBI:24875" FT /evidence="ECO:0000256|PIRSR:PIRSR602481-2" FT BINDING 125 FT /ligand="Fe cation" FT /ligand_id="ChEBI:CHEBI:24875" FT /evidence="ECO:0000256|PIRSR:PIRSR602481-2" FT BINDING 133 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000256|PIRSR:PIRSR602481-1" FT BINDING 136 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000256|PIRSR:PIRSR602481-1" SQ SEQUENCE 140 AA; 16102 MW; ED84260E06238F48 CRC64; MNSKNLDLKE FGFKVTQPRV EILKLFEKNK DKHLSPDGVF SKLKAQGSST GIATVYRVLN QFESAGIINR LKFYNEQAMY ELNNGEHHDH IICIKCNIIQ EFYSPEIEAL QKQIVESFGA EMINHSLNIY VKCKSCSEKE //