ID A0A0K1SD39_9HIV1 Unreviewed; 845 AA. AC A0A0K1SD39; DT 11-NOV-2015, integrated into UniProtKB/TrEMBL. DT 11-NOV-2015, sequence version 1. DT 25-OCT-2017, entry version 17. DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|RuleBase:RU363095}; DE Contains: DE RecName: Full=Surface protein gp120 {ECO:0000256|RuleBase:RU363095}; DE Short=SU {ECO:0000256|RuleBase:RU363095}; DE AltName: Full=Glycoprotein 120 {ECO:0000256|RuleBase:RU363095}; DE Short=gp120 {ECO:0000256|RuleBase:RU363095}; DE Contains: DE RecName: Full=Transmembrane protein gp41 {ECO:0000256|RuleBase:RU363095}; DE Short=TM {ECO:0000256|RuleBase:RU363095}; GN Name=env {ECO:0000313|EMBL:AKV72548.1}; OS Human immunodeficiency virus 1. OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Lentivirus; Primate lentivirus group. OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AKV72548.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:AKV72548.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CH0457_w04_e14 {ECO:0000313|EMBL:AKV72548.1}; RX PubMed=26355218; DOI=10.1016/j.chom.2015.08.006; RA Moody M.A., Gao F., Gurley T.C., Amos J.D., Kumar A., Hora B., RA Marshall D.J., Whitesides J.F., Xia S.M., Parks R., Lloyd K.E., RA Hwang K.K., Lu X., Bonsignori M., Finzi A., Vandergrift N.A., RA Alam S.M., Ferrari G., Shen X., Tomaras G.D., Kamanga G., Cohen M.S., RA Sam N.E., Kapiga S., Gray E.S., Tumba N.L., Morris L., RA Zolla-Pazner S., Gorny M.K., Mascola J.R., Hahn B.H., Shaw G.M., RA Sodroski J.G., Liao H.X., Montefiori D.C., Hraber P.T., Korber B.T., RA Haynes B.F.; RT "Strain-Specific V3 and CD4 Binding Site Autologous HIV-1 Neutralizing RT Antibodies Select Neutralization-Resistant Viruses."; RL Cell Host Microbe 18:354-362(2015). RN [2] {ECO:0000313|EMBL:AKV72548.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CH0457_w04_e14 {ECO:0000313|EMBL:AKV72548.1}; RA Hoefler B.C., Straight P.D.; RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases. CC -!- SUBUNIT: The mature envelope protein (Env) consists of a CC homotrimer of non-covalently associated gp120-gp41 heterodimers. CC The resulting complex protrudes from the virus surface as a spike. CC {ECO:0000256|RuleBase:RU363095}. CC -!- SUBCELLULAR LOCATION: Host cell membrane CC {ECO:0000256|SAAS:SAAS00937286}; Peripheral membrane protein CC {ECO:0000256|SAAS:SAAS00937286}. CC -!- SUBCELLULAR LOCATION: Host cell membrane CC {ECO:0000256|SAAS:SAAS00936930}; Single-pass type I membrane CC protein {ECO:0000256|SAAS:SAAS00936930}. CC -!- SUBCELLULAR LOCATION: Host endosome membrane CC {ECO:0000256|SAAS:SAAS00937040}; Single-pass type I membrane CC protein {ECO:0000256|SAAS:SAAS00937040}. CC -!- SUBCELLULAR LOCATION: Virion membrane CC {ECO:0000256|SAAS:SAAS00796993}; Single-pass type I membrane CC protein {ECO:0000256|SAAS:SAAS00796993}. CC -!- DOMAIN: The 17 amino acids long immunosuppressive region is CC present in many retroviral envelope proteins. Synthetic peptides CC derived from this relatively conserved sequence inhibit immune CC function in vitro and in vivo. {ECO:0000256|RuleBase:RU363095}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|RuleBase:RU363095}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KT220838; AKV72548.1; -; Genomic_RNA. DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-UniRule. DR CDD; cd09909; HIV-1-like_HR1-HR2; 1. DR Gene3D; 2.170.40.20; -; 2. DR InterPro; IPR036377; Gp120_core_sf. DR InterPro; IPR000328; GP41-like. DR InterPro; IPR000777; HIV1_Gp120. DR Pfam; PF00516; GP120; 2. DR Pfam; PF00517; GP41; 1. DR SUPFAM; SSF56502; SSF56502; 2. PE 4: Predicted; KW Apoptosis {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00936854}; KW Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU363095}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00881052}; KW Fusion of virus membrane with host membrane KW {ECO:0000256|RuleBase:RU363095, ECO:0000256|SAAS:SAAS00487637}; KW Host cell membrane {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00936840}; KW Host endosome {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00936869}; KW Host membrane {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00937255}; KW Host-virus interaction {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797036}; KW Membrane {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797370}; KW Transmembrane {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797262}; KW Transmembrane helix {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797734}; KW Viral attachment to host cell {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797747}; KW Viral envelope protein {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797156, ECO:0000313|EMBL:AKV72548.1}; KW Viral penetration into host cytoplasm {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00132213}; KW Virion {ECO:0000256|RuleBase:RU363095, ECO:0000256|SAAS:SAAS00796948}; KW Virus entry into host cell {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797206}. FT TRANSMEM 13 41 Helical. {ECO:0000256|RuleBase:RU363095}. FT TRANSMEM 494 517 Helical. {ECO:0000256|RuleBase:RU363095}. FT TRANSMEM 660 687 Helical. {ECO:0000256|RuleBase:RU363095}. FT DOMAIN 33 141 GP120. {ECO:0000259|Pfam:PF00516}. FT DOMAIN 141 493 GP120. {ECO:0000259|Pfam:PF00516}. FT DOMAIN 512 702 GP41. {ECO:0000259|Pfam:PF00517}. SQ SEQUENCE 845 AA; 95863 MW; 07DECD935EEB4505 CRC64; MKVMEILRKW KHWWIWGILG FWMLLISNVM GNLWVTVYYG VPVWREAKTT LFCASDAKAY EREVHNVWAT HACVPTDPNP QEMRLENVTE NFNMWKNDMV DQMHEDIISL WDQSLKPCVK LTPLCVTLRC ENATYNDTNY KNITDGEVMN CSFNITTEIR DKRRKESALF YRVDIVPLDN NSAEYRLINC KTSSLTQACP KISFDPIPIH YCAPAGYAIL KCNNKTFNGT GPCNSVSTVQ CTHGIKPVVS TQLLLNGSLA EEDIIIRSEN LTDNAKIIIV HLNKSVEIRC TRPGNNTRKS VRIGPGQTFY ATGEIIGDIR KAHCNISRSK WNEALERISN KLEAHFPNKT IQFNSSSGGD LEITTHSFNC RGEFFYCNTS KLFNNNRTSN NSSYITIPCK IKQIINMWQK VGKAMYAPPI AGNITCTSNI TGILSTRDGG NNSDSDPETF RPTGGDMRDN WRSELYKYKV VEVEPLGIAP TGAKRRVVER QKRAVGMGAM FLGFLGAAGS TMGAASITLT VQARQLLSGI VQQQSNLLRA IEAQQHILQL TVWGIKQLQT RILAIERYLK DQQLLGIWGC SGKLICTTSV PWNSSWSNKS ESEIWNNMTW MQWDKEISNY TNTIYRLLEE SQNQQEKNEQ DLLALDSWKN LWSWFSITNW LWYIKIFIMI VGGLIGLRII FAILSIVNRV RQGYSPLSFQ TLTPNPRGPD RLGRIEEGGG EQDNARSTRL VSGFLALAWD DLRSLFLFSY HRLRDFTLIV VGGGELLGRS SLRGLQKGWE TLKYLGNLVQ YWGLELKRSA ISLLDTIAIA TAEGTDRIIE LVQRICRAIC NVPTRIRQGF EAALQ //