ID A0A0K1HC83_9HIV1 Unreviewed; 211 AA. AC A0A0K1HC83; DT 11-NOV-2015, integrated into UniProtKB/TrEMBL. DT 11-NOV-2015, sequence version 1. DT 18-JAN-2017, entry version 8. DE RecName: Full=Protein Nef {ECO:0000256|RuleBase:RU000344, ECO:0000256|SAAS:SAAS00118351}; GN Name=nef {ECO:0000313|EMBL:AKT78734.1}; OS Human immunodeficiency virus 1. OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Lentivirus; Primate lentivirus group. OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AKT78734.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:AKT78734.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=R7-578 {ECO:0000313|EMBL:AKT78734.1}, and R7-586 RC {ECO:0000313|EMBL:AKT78735.1}; RX PubMed=26375597; RA Cuevas J.M., Geller R., Garijo R., Lopez-Aldeguer J., Sanjuan R.; RT "Extremely High Mutation Rate of HIV-1 In Vivo."; RL PLoS Biol. 13:E1002251-E1002251(2015). RN [2] {ECO:0000313|EMBL:AKT78734.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=R7-578 {ECO:0000313|EMBL:AKT78734.1}, and R7-586 RC {ECO:0000313|EMBL:AKT78735.1}; RA Hoefler B.C., Straight P.D.; RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases. CC -!- SUBUNIT: Homodimer. {ECO:0000256|SAAS:SAAS00536203}. CC -!- SUBCELLULAR LOCATION: Host cell membrane CC {ECO:0000256|SAAS:SAAS00536205}; Lipid-anchor CC {ECO:0000256|SAAS:SAAS00536205}; Cytoplasmic side CC {ECO:0000256|SAAS:SAAS00536205}. CC -!- SIMILARITY: Belongs to the lentivirus primate group Nef protein CC family. {ECO:0000256|RuleBase:RU000344, CC ECO:0000256|SAAS:SAAS00536190}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KT205530; AKT78734.1; -; Genomic_DNA. DR EMBL; KT205531; AKT78735.1; -; Genomic_DNA. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0005525; F:GTP binding; IEA:InterPro. DR GO; GO:0030683; P:evasion or tolerance by virus of host immune response; IEA:UniProtKB-KW. DR GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW. DR Gene3D; 3.30.62.10; -; 1. DR Gene3D; 4.10.890.10; -; 1. DR InterPro; IPR027480; HIV-1_Nef_anchor. DR InterPro; IPR027481; HIV-1_Nef_core. DR InterPro; IPR001558; HIV_Nef. DR Pfam; PF00469; F-protein; 1. DR SUPFAM; SSF55671; SSF55671; 1. PE 3: Inferred from homology; KW Host cell membrane {ECO:0000256|SAAS:SAAS00004523}; KW Host membrane {ECO:0000256|SAAS:SAAS00118235}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS00004502}; KW Lipoprotein {ECO:0000256|RuleBase:RU000344}; KW Membrane {ECO:0000256|SAAS:SAAS00004519}; KW Myristate {ECO:0000256|RuleBase:RU000344}; KW Viral immunoevasion {ECO:0000256|RuleBase:RU000344}; KW Virulence {ECO:0000256|RuleBase:RU000344}. SQ SEQUENCE 211 AA; 24217 MW; 1FCD74B2A09486AD CRC64; MGGKWSKIRE TGWPAIRERM RRAEPAAAEP AAEGVGAVSR DLEKYGAVTN SNTAATNSDC AWLEAQEEEE EVGFPVRPQV PLRPMTYKGA LDLSHFLKEK GGLEGLIWSQ QRQDILDLWV YNTQGFFPDW QNYTPGPGIR YPLTFGWCFK LVPVEKEEVE EANAGENNCL LHPMNQHGME DPEREVLRWK FDSRLAFHHV AREKHPEYYK N //