ID A0A0K0JFP3_BRUMA Unreviewed; 572 AA. AC A0A0K0JFP3; DT 14-OCT-2015, integrated into UniProtKB/TrEMBL. DT 14-OCT-2015, sequence version 1. DT 11-NOV-2015, entry version 2. DE RecName: Full=Hexokinase {ECO:0000256|RuleBase:RU362007}; DE EC=2.7.1.1 {ECO:0000256|RuleBase:RU362007}; GN Name=Bm1_14445 {ECO:0000313|WBParaSite:Bm4678}; GN Synonyms=Bm4678 {ECO:0000313|EMBL:CRZ23240.1}; GN ORFNames=BM_Bm4678 {ECO:0000313|EMBL:CRZ23240.1}; OS Brugia malayi (Filarial nematode worm). OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Spirurida; OC Filarioidea; Onchocercidae; Brugia. OX NCBI_TaxID=6279 {ECO:0000313|Proteomes:UP000006672, ECO:0000313|WBParaSite:Bm4678}; RN [1] {ECO:0000313|EMBL:CRZ23240.1, ECO:0000313|Proteomes:UP000006672, ECO:0000313|WBParaSite:Bm4678} RP NUCLEOTIDE SEQUENCE. RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ23240.1}; RX PubMed=17885136; DOI=10.1126/science.1145406; RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., RA Allen J.E., Delcher A.L., Guiliano D.B., Miranda-Saavedra D., RA Angiuoli S.V., Creasy T., Amedeo P., Haas B., El-Sayed N.M., RA Wortman J.R., Feldblyum T., Tallon L., Schatz M., Shumway M., Koo H., RA Salzberg S.L., Schobel S., Pertea M., Pop M., White O., Barton G.J., RA Carlow C.K., Crawford M.J., Daub J., Dimmic M.W., Estes C.F., RA Foster J.M., Ganatra M., Gregory W.F., Johnson N.M., Jin J., RA Komuniecki R., Korf I., Kumar S., Laney S., Li B.W., Li W., RA Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M., RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J., RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E., RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G., RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B., RA Blaxter M.L., Scott A.L.; RT "Draft genome of the filarial nematode parasite Brugia malayi."; RL Science 317:1756-1760(2007). RN [2] {ECO:0000313|Proteomes:UP000026912} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lucero-Rivera Y.E., Tovar-Ramirez D.; RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:CRZ23240.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ23240.1}; RG WormBase Consortium; RA Ghedin E., Paulini M.; RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|WBParaSite:Bm4678} RP IDENTIFICATION. RG WormBaseParasite; RL Submitted (SEP-2015) to UniProtKB. RN [5] {ECO:0000313|Proteomes:UP000026912} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG RefSeq; RL Submitted (SEP-2015) to UniProtKB. CC -!- CATALYTIC ACTIVITY: ATP + D-hexose = ADP + D-hexose 6-phosphate. CC {ECO:0000256|RuleBase:RU362007}. CC -!- SIMILARITY: Belongs to the hexokinase family. CC {ECO:0000256|RuleBase:RU004510}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CAPY01003893; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; LN856840; CRZ23240.1; -; Genomic_DNA. DR WBParaSite; Bm4678; Bm4678; WBGene00224939. DR Proteomes; UP000006672; Unassembled WGS sequence. DR Proteomes; UP000026912; Unassembled WGS sequence. DR InterPro; IPR001312; Hexokinase. DR InterPro; IPR022673; Hexokinase_C. DR InterPro; IPR022672; Hexokinase_N. DR PANTHER; PTHR19443; PTHR19443; 1. DR Pfam; PF00349; Hexokinase_1; 1. DR Pfam; PF03727; Hexokinase_2; 1. DR PROSITE; PS51748; HEXOKINASE_2; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|RuleBase:RU362007, KW ECO:0000256|SAAS:SAAS00315249}; Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000006672, KW ECO:0000313|Proteomes:UP000026912}; KW Glycolysis {ECO:0000256|RuleBase:RU362007, KW ECO:0000256|SAAS:SAAS00315250}; KW Kinase {ECO:0000256|RuleBase:RU362007, ECO:0000256|SAAS:SAAS00315248}; KW Nucleotide-binding {ECO:0000256|RuleBase:RU362007, KW ECO:0000256|SAAS:SAAS00315247}; KW Transferase {ECO:0000256|RuleBase:RU362007, KW ECO:0000256|SAAS:SAAS00315246}. FT COILED 494 522 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 572 AA; 64043 MW; C2675B140514684B CRC64; MLGLLTITSV FRNWRNSLQR KEDYDECHMR GINNENEISG KSEKNFKLDE PPISLETVMA EFKLSNETLR RMMAHMSRNM DKGLEGGPEN STISMLPSFV PELPNGTEEG RFIAMDLGGT NLRVMLMDIK PGEELKTEQF NTRIPNWAMR GTGEQLFDYI TKCLAEFLIE KGIENDGLPV GFTFSYPCDQ KSLRSATLLR WTKGFETTGV VGEDVVELLE QSIARRGDIK VEVVALINDT VGTMVAAAHE SGGECHIGVI IATGTNASYM EDTSKIKYGL SKAIAAYNYP EMIIDTEWGG FGDRSEADYI LTQYDKIVDS RSEHPGVNTF DKLVGGKCMG EVVRVVLEKL TRARVLFNGK GSDALFQQDS FPTKYISEIL RDESGSYVHT RDILGELGID HYSFSDMLLL REVCVVVSRR SANLGAAAIA CVLNRVRKQN MVVGIDGSTY KYHPFFDFWV HDKLKELVDP GLKFKLLQTA DGSGKGAALI TAIVARLKKR NLKQQQQQQQ QQQQHVTMVE QNVVEQIAET KGSREQFMNG NQKINLVTND IPIYDSFNGD IENGVIHLST DH //