ID A0A0J9YUV2_MOUSE Unreviewed; 198 AA. AC A0A0J9YUV2; DT 14-OCT-2015, integrated into UniProtKB/TrEMBL. DT 14-OCT-2015, sequence version 1. DT 02-OCT-2024, entry version 47. DE SubName: Full=YES proto-oncogene 1, Src family tyrosine kinase {ECO:0000313|Ensembl:ENSMUSP00000144355.2}; DE Flags: Fragment; GN Name=Yes1 {ECO:0000313|Ensembl:ENSMUSP00000144355.2, GN ECO:0000313|MGI:MGI:99147}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000144355.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000144355.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000144355.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RG Mouse Genome Sequencing Consortium; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000144355.2} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000144355.2}; RX PubMed=21750661; RA Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N., RA Chen H.C., Agarwala R., McLaren W.M., Ritchie G.R., Albracht D., RA Kremitzki M., Rock S., Kotkiewicz H., Kremitzki C., Wollam A., Trani L., RA Fulton L., Fulton R., Matthews L., Whitehead S., Chow W., Torrance J., RA Dunn M., Harden G., Threadgold G., Wood J., Collins J., Heath P., RA Griffiths G., Pelan S., Grafham D., Eichler E.E., Weinstock G., RA Mardis E.R., Wilson R.K., Howe K., Flicek P., Hubbard T.; RT "Modernizing reference genome assemblies."; RL PLoS Biol. 9:e1001091-e1001091(2011). RN [4] {ECO:0000313|Ensembl:ENSMUSP00000144355.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000144355.2}; RG Ensembl; RL Submitted (JUN-2024) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; A0A0J9YUV2; -. DR SMR; A0A0J9YUV2; -. DR ProteomicsDB; 326263; -. DR Antibodypedia; 3819; 539 antibodies from 37 providers. DR Ensembl; ENSMUST00000200999.2; ENSMUSP00000144355.2; ENSMUSG00000014932.16. DR AGR; MGI:99147; -. DR MGI; MGI:99147; Yes1. DR VEuPathDB; HostDB:ENSMUSG00000014932; -. DR GeneTree; ENSGT00940000154920; -. DR OMA; ESNEWHF; -. DR ChiTaRS; Yes1; mouse. DR Proteomes; UP000000589; Chromosome 5. DR Bgee; ENSMUSG00000014932; Expressed in lumbar dorsal root ganglion and 248 other cell types or tissues. DR ExpressionAtlas; A0A0J9YUV2; baseline and differential. DR CDD; cd12007; SH3_Yes; 1. DR Gene3D; 3.30.505.10; SH2 domain; 1. DR Gene3D; 2.30.30.40; SH3 Domains; 1. DR InterPro; IPR043539; Grb2-like. DR InterPro; IPR000980; SH2. DR InterPro; IPR036860; SH2_dom_sf. DR InterPro; IPR036028; SH3-like_dom_sf. DR InterPro; IPR001452; SH3_domain. DR InterPro; IPR035751; Yes_SH3. DR PANTHER; PTHR46037:SF1; GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2; 1. DR PANTHER; PTHR46037; PROTEIN ENHANCER OF SEVENLESS 2B; 1. DR Pfam; PF00017; SH2; 1. DR Pfam; PF00018; SH3_1; 1. DR PRINTS; PR00401; SH2DOMAIN. DR PRINTS; PR00452; SH3DOMAIN. DR SMART; SM00326; SH3; 1. DR SUPFAM; SSF50044; SH3-domain; 1. DR PROSITE; PS50001; SH2; 1. DR PROSITE; PS50002; SH3; 1. PE 1: Evidence at protein level; KW Lipoprotein {ECO:0000256|ARBA:ARBA00022707}; KW Myristate {ECO:0000256|ARBA:ARBA00022707}; KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A0J9YUV2, KW ECO:0007829|ProteomicsDB:A0A0J9YUV2}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}; KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE- KW ProRule:PRU00192}. FT DOMAIN 89..150 FT /note="SH3" FT /evidence="ECO:0000259|PROSITE:PS50002" FT DOMAIN 156..198 FT /note="SH2" FT /evidence="ECO:0000259|PROSITE:PS50001" FT NON_TER 198 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000144355.2" SQ SEQUENCE 198 AA; 21336 MW; CA2D3E998F7BC5A3 CRC64; MGCIKSKENK SPAIKYTPEN LTEPVSPSAS HYGVEHATVA PTSSTKGASV NFNSLSMTPF GGSSGVTPFG GASSSFSVVS SSYPTGLTGG VTIFVALYDY EARTTEDLSF KKGERFQIIN NTEGDWWEAR SIATGKSGYI PSNYVVPADS IQAEEWYFGK MGRKDAERLL LNPGNQRGIF LVRESETTKG AYSLSIRD //