ID A0A0J9YUV2_MOUSE Unreviewed; 198 AA. AC A0A0J9YUV2; DT 14-OCT-2015, integrated into UniProtKB/TrEMBL. DT 14-OCT-2015, sequence version 1. DT 20-JAN-2016, entry version 4. DE SubName: Full=Tyrosine-protein kinase Yes {ECO:0000313|Ensembl:ENSMUSP00000144355}; DE Flags: Fragment; GN Name=Yes1 {ECO:0000313|Ensembl:ENSMUSP00000144355, GN ECO:0000313|MGI:MGI:99147}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000144355, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000144355, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000144355, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000213|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000144355} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000144355}; RG Ensembl; RL Submitted (AUG-2015) to UniProtKB. CC -!- SIMILARITY: Contains 1 SH3 domain. CC {ECO:0000256|RuleBase:RU003338}. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000144355}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC091274; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC166934; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMUST00000200999; ENSMUSP00000144355; ENSMUSG00000014932. DR MGI; MGI:99147; Yes1. DR GeneTree; ENSGT00760000118938; -. DR Proteomes; UP000000589; Chromosome 5. DR GO; GO:0005884; C:actin filament; IDA:MGI. DR GO; GO:0005737; C:cytoplasm; ISO:MGI. DR GO; GO:0070062; C:extracellular exosome; ISO:MGI. DR GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IBA:GO_Central. DR GO; GO:0005925; C:focal adhesion; ISO:MGI. DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI. DR GO; GO:0005886; C:plasma membrane; IDA:MGI. DR GO; GO:0019899; F:enzyme binding; ISO:MGI. DR GO; GO:0044325; F:ion channel binding; ISO:MGI. DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IBA:GO_Central. DR GO; GO:0004713; F:protein tyrosine kinase activity; ISO:MGI. DR GO; GO:0005102; F:receptor binding; IBA:GO_Central. DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central. DR GO; GO:0071375; P:cellular response to peptide hormone stimulus; IBA:GO_Central. DR GO; GO:0036120; P:cellular response to platelet-derived growth factor stimulus; IDA:MGI. DR GO; GO:0071300; P:cellular response to retinoic acid; IDA:MGI. DR GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IGI:MGI. DR GO; GO:0015758; P:glucose transport; IDA:MGI. DR GO; GO:0045087; P:innate immune response; IBA:GO_Central. DR GO; GO:0038083; P:peptidyl-tyrosine autophosphorylation; IBA:GO_Central. DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:MGI. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI. DR GO; GO:0042127; P:regulation of cell proliferation; IBA:GO_Central. DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central. DR Gene3D; 3.30.505.10; -; 1. DR InterPro; IPR000980; SH2. DR InterPro; IPR001452; SH3_domain. DR Pfam; PF00017; SH2; 1. DR Pfam; PF00018; SH3_1; 1. DR PRINTS; PR00401; SH2DOMAIN. DR PRINTS; PR00452; SH3DOMAIN. DR SMART; SM00326; SH3; 1. DR SUPFAM; SSF50044; SSF50044; 1. DR PROSITE; PS50001; SH2; 1. DR PROSITE; PS50002; SH3; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Proteomics identification {ECO:0000213|MaxQB:A0A0J9YUV2, KW ECO:0000213|PeptideAtlas:A0A0J9YUV2}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW SH3 domain {ECO:0000256|RuleBase:RU003338}. FT DOMAIN 89 150 SH3. {ECO:0000259|PROSITE:PS50002}. FT DOMAIN 156 198 SH2. {ECO:0000259|PROSITE:PS50001}. FT NON_TER 198 198 {ECO:0000313|Ensembl:ENSMUSP00000144355}. SQ SEQUENCE 198 AA; 21336 MW; CA2D3E998F7BC5A3 CRC64; MGCIKSKENK SPAIKYTPEN LTEPVSPSAS HYGVEHATVA PTSSTKGASV NFNSLSMTPF GGSSGVTPFG GASSSFSVVS SSYPTGLTGG VTIFVALYDY EARTTEDLSF KKGERFQIIN NTEGDWWEAR SIATGKSGYI PSNYVVPADS IQAEEWYFGK MGRKDAERLL LNPGNQRGIF LVRESETTKG AYSLSIRD //