ID A0A0J8U3I0_COCIT Unreviewed; 304 AA. AC A0A0J8U3I0; DT 14-OCT-2015, integrated into UniProtKB/TrEMBL. DT 14-OCT-2015, sequence version 1. DT 13-NOV-2019, entry version 16. DE RecName: Full=TOP4c domain-containing protein {ECO:0000259|Pfam:PF00521}; GN ORFNames=CISG_08743 {ECO:0000313|EMBL:KMU81332.1}; OS Coccidioides immitis RMSCC 3703. OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Coccidioides. OX NCBI_TaxID=454286 {ECO:0000313|EMBL:KMU81332.1, ECO:0000313|Proteomes:UP000054559}; RN [1] {ECO:0000313|Proteomes:UP000054559} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=RMSCC 3703 {ECO:0000313|Proteomes:UP000054559}; RX PubMed=20516208; DOI=10.1101/gr.103911.109; RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J., RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D., RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A., RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J., RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R., RA Taylor J.W., Rounsley S.D.; RT "Population genomic sequencing of Coccidioides fungi reveals recent RT hybridization and transposon control."; RL Genome Res. 20:938-946(2010). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DS268197; KMU81332.1; -; Genomic_DNA. DR EnsemblFungi; KMU81332; KMU81332; CISG_08743. DR Proteomes; UP000054559; Unassembled WGS sequence. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0003677; F:DNA binding; IEA:InterPro. DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:InterPro. DR GO; GO:0006265; P:DNA topological change; IEA:InterPro. DR Gene3D; 1.10.268.10; -; 1. DR InterPro; IPR013760; Topo_IIA-like_dom_sf. DR InterPro; IPR002205; Topo_IIA_A/C. DR InterPro; IPR013757; Topo_IIA_A_a_sf. DR Pfam; PF00521; DNA_topoisoIV; 1. DR SUPFAM; SSF56719; SSF56719; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000054559}; KW Reference proteome {ECO:0000313|Proteomes:UP000054559}. FT DOMAIN 1 109 TOP4c. {ECO:0000259|Pfam:PF00521}. FT REGION 31 57 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 122 304 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT COILED 78 98 {ECO:0000256|SAM:Coils}. FT COMPBIAS 41 57 Acidic. {ECO:0000256|SAM:MobiDB-lite}. FT COMPBIAS 150 166 Polyampholyte. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 194 212 Polyampholyte. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 222 246 Polyampholyte. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 257 298 Polyampholyte. {ECO:0000256|SAM:MobiDB- FT lite}. SQ SEQUENCE 304 AA; 34438 MW; 0A183FD7548E68B4 CRC64; MIIDGKLVIS KKRKAKLIEE LKEKGFKPIP KAVDAAKEGE NEPAVEEEEE SEEDEQLSSD VFDYLLGMPL WSLTQERVEK LLRQIGDKEL EIDALIKLSK EDLWKRDLDE FITEWRNQLE DEERRAKKAR SYGRRTSTKL KTAGRAPAGK KRKALGDDDD SDFAPKAKKA TVVNKVKPKG GLLDYLSKPA AKSKTKATRL DSTKEIESRF EQKPRGGYYI SFSDSEDDKD DILSKETDEK ARDPTRPPSP DIPAISDSDD YKPKPAKKAT AVSKKAPKEH DDSDTEIVQR HASEQIAHPK AYRI //