ID A0A0J8R9Z2_COCIT Unreviewed; 317 AA. AC A0A0J8R9Z2; DT 14-OCT-2015, integrated into UniProtKB/TrEMBL. DT 14-OCT-2015, sequence version 1. DT 29-SEP-2021, entry version 22. DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551}; DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551}; GN ORFNames=CISG_09377 {ECO:0000313|EMBL:KMU81909.1}; OS Coccidioides immitis RMSCC 3703. OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Coccidioides. OX NCBI_TaxID=454286 {ECO:0000313|EMBL:KMU81909.1, ECO:0000313|Proteomes:UP000054559}; RN [1] {ECO:0000313|Proteomes:UP000054559} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=RMSCC 3703 {ECO:0000313|Proteomes:UP000054559}; RX PubMed=20516208; DOI=10.1101/gr.103911.109; RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J., RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D., RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A., RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J., RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R., RA Taylor J.W., Rounsley S.D.; RT "Population genomic sequencing of Coccidioides fungi reveals recent RT hybridization and transposon control."; RL Genome Res. 20:938-946(2010). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; CC Evidence={ECO:0000256|ARBA:ARBA00001665}; CC -!- SUBUNIT: Heterodimer of Ku70 and Ku80. {ECO:0000256|ARBA:ARBA00011584}. CC -!- SUBCELLULAR LOCATION: Chromosome, telomere CC {ECO:0000256|ARBA:ARBA00004574}. Nucleus CC {ECO:0000256|ARBA:ARBA00004123}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DS268208; KMU81909.1; -; Genomic_DNA. DR EnsemblFungi; KMU81909; KMU81909; CISG_09377. DR Proteomes; UP000054559; Unassembled WGS sequence. DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0140603; F:ATP hydrolysis activity; IEA:RHEA. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC. DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW. DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro. DR Gene3D; 2.40.290.10; -; 1. DR Gene3D; 3.40.50.410; -; 1. DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom. DR InterPro; IPR005161; Ku_N. DR InterPro; IPR016194; SPOC-like_C_dom_sf. DR InterPro; IPR002035; VWF_A. DR InterPro; IPR036465; vWFA_dom_sf. DR Pfam; PF02735; Ku; 1. DR Pfam; PF03731; Ku_N; 1. DR SUPFAM; SSF100939; SSF100939; 1. DR SUPFAM; SSF53300; SSF53300; 1. DR PROSITE; PS50234; VWFA; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW Chromosome {ECO:0000256|ARBA:ARBA00022895}; KW DNA damage {ECO:0000256|ARBA:ARBA00022763}; KW DNA recombination {ECO:0000256|ARBA:ARBA00023172}; KW DNA repair {ECO:0000256|ARBA:ARBA00023204}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW Helicase {ECO:0000256|ARBA:ARBA00022806}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Reference proteome {ECO:0000313|Proteomes:UP000054559}; KW Telomere {ECO:0000256|ARBA:ARBA00022895}. FT DOMAIN 1..137 FT /note="VWFA" FT /evidence="ECO:0000259|PROSITE:PS50234" SQ SEQUENCE 317 AA; 34965 MW; EA088B5A6B9E2D19 CRC64; MAEKEATVYI VDVSTGRKTA TVGVVGLRTD GSSNPLWEKD EEESYAHLSV FQEIGQMLMP DIRKLRDLVK PSNTNQGDAI SSIILAIDMI VRYCKRLKYK RKIVLVTDGR STMDSDGIDS IVSKIKEEGI ELVILGVDFD DPDYGFKEED KDPFKVNTCR REMTTPRIKV VRGIPSFRGD LRLGDPSQYS TGLTIQVERY YRTYVARPPA ASAFALSIAP PKGQSTAESS VTLQNGDSTV ETASASNNLS GVRNARSYQV IDENAPGGKK EVEQDDLAKG YEYGRTAVHI SESDEVITKL DTTAALEFIG FIQSENV //