ID A0A0J1ZMJ8_ECOLX Unreviewed; 326 AA. AC A0A0J1ZMJ8; DT 14-OCT-2015, integrated into UniProtKB/TrEMBL. DT 14-OCT-2015, sequence version 1. DT 24-JAN-2024, entry version 62. DE SubName: Full=IS5 transposase and trans-activator {ECO:0000313|EMBL:STL74429.1}; DE SubName: Full=Transposase InsH for insertion sequence element IS5H {ECO:0000313|EMBL:BCG39962.1}; GN Name=insH_2 {ECO:0000313|EMBL:STL74429.1}; GN Synonyms=insH {ECO:0000313|EMBL:STE54642.1}, insH6 GN {ECO:0000313|EMBL:BCG39962.1}, insH_1 {ECO:0000313|EMBL:STH85941.1}, GN insH_10 {ECO:0000313|EMBL:STI85366.1}, insH_11 GN {ECO:0000313|EMBL:STI85419.1}, insH_13 {ECO:0000313|EMBL:STI85903.1}, GN insH_14 {ECO:0000313|EMBL:STI86067.1}, insH_15 GN {ECO:0000313|EMBL:STI86453.1}, insH_16 {ECO:0000313|EMBL:STI86502.1}, GN insH_18 {ECO:0000313|EMBL:STI86991.1}, insH_20 GN {ECO:0000313|EMBL:STI87725.1}, insH_21 {ECO:0000313|EMBL:STI88145.1}, GN insH_3 {ECO:0000313|EMBL:STI81999.1}, insH_4 GN {ECO:0000313|EMBL:STL82834.1}, insH_6 {ECO:0000313|EMBL:STI83188.1}; GN ORFNames=NCTC10764_01302 {ECO:0000313|EMBL:STE54642.1}, GN NCTC13148_01801 {ECO:0000313|EMBL:STL74429.1}, NCTC13148_02110 GN {ECO:0000313|EMBL:STL76039.1}, NCTC13148_03190 GN {ECO:0000313|EMBL:STL82834.1}, NCTC8622_00952 GN {ECO:0000313|EMBL:STI81999.1}, NCTC8622_02203 GN {ECO:0000313|EMBL:STI83188.1}, NCTC8622_04457 GN {ECO:0000313|EMBL:STI85366.1}, NCTC8622_04512 GN {ECO:0000313|EMBL:STI85419.1}, NCTC8622_05012 GN {ECO:0000313|EMBL:STI85903.1}, NCTC8622_05182 GN {ECO:0000313|EMBL:STI86067.1}, NCTC8622_05576 GN {ECO:0000313|EMBL:STI86453.1}, NCTC8622_05627 GN {ECO:0000313|EMBL:STI86502.1}, NCTC8622_06140 GN {ECO:0000313|EMBL:STI86991.1}, NCTC8622_06900 GN {ECO:0000313|EMBL:STI87725.1}, NCTC8622_07338 GN {ECO:0000313|EMBL:STI88145.1}, NCTC9050_00944 GN {ECO:0000313|EMBL:STH85941.1}, NCTC9050_02636 GN {ECO:0000313|EMBL:STH87555.1}, TUM18780_51240 GN {ECO:0000313|EMBL:BCG39962.1}; OS Escherichia coli. OG Plasmid pMTY18780-5_IncX3 {ECO:0000313|EMBL:BCG39962.1}, and OG Plasmid pmty18780-5_incx3 dna {ECO:0000313|Proteomes:UP000509260}. OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=562 {ECO:0000313|EMBL:STL74429.1, ECO:0000313|Proteomes:UP000254255}; RN [1] {ECO:0000313|Proteomes:UP000254079, ECO:0000313|Proteomes:UP000254255} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NCTC10764 {ECO:0000313|EMBL:STE54642.1, RC ECO:0000313|Proteomes:UP000255201}, NCTC13148 RC {ECO:0000313|EMBL:STL74429.1, ECO:0000313|Proteomes:UP000254255}, RC NCTC8622 {ECO:0000313|EMBL:STI81999.1, RC ECO:0000313|Proteomes:UP000254079}, and NCTC9050 RC {ECO:0000313|EMBL:STH85941.1, ECO:0000313|Proteomes:UP000254972}; RG Pathogen Informatics; RA Doyle S.; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:BCG39962.1, ECO:0000313|Proteomes:UP000509260} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=TUM18780 {ECO:0000313|EMBL:BCG39962.1, RC ECO:0000313|Proteomes:UP000509260}; RC PLASMID=pMTY18780-5_IncX3 {ECO:0000313|EMBL:BCG39962.1}, and RC pmty18780-5_incx3 dna {ECO:0000313|Proteomes:UP000509260}; RA Ito Y., Aoki K., Nakayama N., Ohtsuka M., Ota M., Kaneko N., Yoshida M., RA Ishii Y., Tateda K., Matsuse H.; RT "Whole-genome sequencing of blaNDM-5 positive Escherichia coli isolated RT from a Japanese patient with no history of travel abroad."; RL Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the transposition of the insertion sequence IS5. CC {ECO:0000256|ARBA:ARBA00003544}. CC -!- SIMILARITY: Belongs to the transposase 11 family. CC {ECO:0000256|ARBA:ARBA00010075}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP023202; BCG39962.1; -; Genomic_DNA. DR EMBL; UFZL01000001; STE54642.1; -; Genomic_DNA. DR EMBL; UGBX01000001; STH85941.1; -; Genomic_DNA. DR EMBL; UGBX01000001; STH87555.1; -; Genomic_DNA. DR EMBL; UGCP01000002; STI81999.1; -; Genomic_DNA. DR EMBL; UGCP01000002; STI83188.1; -; Genomic_DNA. DR EMBL; UGCP01000002; STI85366.1; -; Genomic_DNA. DR EMBL; UGCP01000002; STI85419.1; -; Genomic_DNA. DR EMBL; UGCP01000002; STI85903.1; -; Genomic_DNA. DR EMBL; UGCP01000002; STI86067.1; -; Genomic_DNA. DR EMBL; UGCP01000002; STI86453.1; -; Genomic_DNA. DR EMBL; UGCP01000002; STI86502.1; -; Genomic_DNA. DR EMBL; UGCP01000002; STI86991.1; -; Genomic_DNA. DR EMBL; UGCP01000002; STI87725.1; -; Genomic_DNA. DR EMBL; UGCP01000002; STI88145.1; -; Genomic_DNA. DR EMBL; UGET01000004; STL74429.1; -; Genomic_DNA. DR EMBL; UGET01000004; STL76039.1; -; Genomic_DNA. DR EMBL; UGET01000004; STL82834.1; -; Genomic_DNA. DR RefSeq; WP_000019402.1; NZ_WVUT01000004.1. DR GeneID; 75202231; -. DR Proteomes; UP000254079; Unassembled WGS sequence. DR Proteomes; UP000254255; Unassembled WGS sequence. DR Proteomes; UP000254972; Unassembled WGS sequence. DR Proteomes; UP000255201; Unassembled WGS sequence. DR Proteomes; UP000509260; Plasmid pmty18780-5_incx3 dna. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0004803; F:transposase activity; IEA:InterPro. DR GO; GO:0006313; P:DNA transposition; IEA:InterPro. DR InterPro; IPR047959; Transpos_IS5. DR InterPro; IPR002559; Transposase_11. DR InterPro; IPR008490; Transposase_InsH_N. DR NCBIfam; NF033581; transpos_IS5_4; 1. DR PANTHER; PTHR35604; TRANSPOSASE INSH FOR INSERTION SEQUENCE ELEMENT IS5A-RELATED; 1. DR PANTHER; PTHR35604:SF2; TRANSPOSASE INSH FOR INSERTION SEQUENCE ELEMENT IS5A-RELATED; 1. DR Pfam; PF01609; DDE_Tnp_1; 1. DR Pfam; PF05598; DUF772; 1. PE 3: Inferred from homology; KW DNA recombination {ECO:0000256|ARBA:ARBA00023172}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW Plasmid {ECO:0000313|EMBL:BCG39962.1}; KW Transposable element {ECO:0000256|ARBA:ARBA00022464}; KW Transposition {ECO:0000256|ARBA:ARBA00022578}. FT DOMAIN 51..124 FT /note="Transposase InsH N-terminal" FT /evidence="ECO:0000259|Pfam:PF05598" FT DOMAIN 138..312 FT /note="Transposase IS4-like" FT /evidence="ECO:0000259|Pfam:PF01609" SQ SEQUENCE 326 AA; 37823 MW; 9EFD70482D0324E6 CRC64; MSHQLTFADS EFSSKRRQTR KEIFLSRMEQ ILPWQNMVEV IEPFYPKAGN GRRPYPLETM LRIHCMQHWY NLSDGAMEDA LYEIASMRLF ARLSLDSALP DRTTIMNFRH LLEQHQLARQ LFKTINRWLA EAGVMMTQGT LVDATIIEAP SSTKNKEQQR DPEMHQTKKG NQWHFGMKAH IGVDAKSGLT HSLVTTAANE HDLNQLGNLL HGEEQFVSAD AGYQGAPQRE ELAEVDVDWL IAERPGKVRT LKQHPRKNKT AINIEYMKAS IRAKVEHPFR IIKRQFGFVK ARYKGLLKND NQLAMLFTLA NLFRADQMIR QWERSH //