ID A0A0H5S397_BRUMA Unreviewed; 347 AA. AC A0A0H5S397; DT 14-OCT-2015, integrated into UniProtKB/TrEMBL. DT 14-OCT-2015, sequence version 1. DT 27-NOV-2024, entry version 44. DE RecName: Full=Calcium uniporter protein {ECO:0000256|RuleBase:RU367035}; GN Name=Bma-mcu-1 {ECO:0000313|EMBL:CRZ22680.1, GN ECO:0000313|WBParaSite:Bm4745a.1}; GN ORFNames=BM_Bm4745 {ECO:0000313|EMBL:CRZ22680.1}; OS Brugia malayi (Filarial nematode worm). OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia. OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CRZ22680.1}; RN [1] {ECO:0000313|EMBL:CRZ22680.1, ECO:0000313|Proteomes:UP000006672} RP NUCLEOTIDE SEQUENCE. RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ22680.1, RC ECO:0000313|Proteomes:UP000006672}; RX PubMed=17885136; DOI=10.1126/science.1145406; RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E., RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T., RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L., RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M., RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J., RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F., RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W., RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M., RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J., RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E., RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G., RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B., RA Blaxter M.L., Scott A.L.; RT "Draft genome of the filarial nematode parasite Brugia malayi."; RL Science 317:1756-1760(2007). RN [2] {ECO:0000313|EMBL:CRZ22680.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ22680.1}; RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C., RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.; RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|WBParaSite:Bm4745a.1} RP IDENTIFICATION. RG WormBaseParasite; RL Submitted (DEC-2019) to UniProtKB. CC -!- FUNCTION: Mitochondrial inner membrane calcium uniporter that mediates CC calcium uptake into mitochondria. Mitochondrial calcium homeostasis CC plays key roles in cellular physiology and regulates cell CC bioenergetics, cytoplasmic calcium signals and activation of cell death CC pathways. {ECO:0000256|RuleBase:RU367035}. CC -!- CATALYTIC ACTIVITY: CC Reaction=Ca(2+)(in) = Ca(2+)(out); Xref=Rhea:RHEA:29671, CC ChEBI:CHEBI:29108; Evidence={ECO:0000256|ARBA:ARBA00036634}; CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000256|ARBA:ARBA00004448, ECO:0000256|RuleBase:RU367035}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004448, CC ECO:0000256|RuleBase:RU367035}. CC -!- DOMAIN: The selectivity filter, in which calcium ions are arranged in CC single file, is composed of two acidic rings separated by one helical CC turn along the central axis of the channel pore. CC {ECO:0000256|RuleBase:RU367035}. CC -!- SIMILARITY: Belongs to the MCU (TC 1.A.77) family. CC {ECO:0000256|ARBA:ARBA00005653, ECO:0000256|RuleBase:RU367035}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LN856618; CRZ22680.1; -; Genomic_DNA. DR AlphaFoldDB; A0A0H5S397; -. DR STRING; 6279.A0A0H5S397; -. DR EnsemblMetazoa; Bm4745a.1; Bm4745a.1; WBGene00225006. DR WBParaSite; Bm4745a.1; Bm4745a.1; WBGene00225006. DR InParanoid; A0A0H5S397; -. DR OMA; DDIYVEY; -. DR OrthoDB; 469277at2759; -. DR Proteomes; UP000006672; Unassembled WGS sequence. DR GO; GO:1990246; C:uniplex complex; IEA:TreeGrafter. DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-UniRule. DR GO; GO:0042802; F:identical protein binding; IEA:EnsemblMetazoa. DR GO; GO:0015292; F:uniporter activity; IEA:UniProtKB-UniRule. DR GO; GO:0036444; P:calcium import into the mitochondrion; IEA:EnsemblMetazoa. DR GO; GO:0051560; P:mitochondrial calcium ion homeostasis; IEA:UniProtKB-UniRule. DR GO; GO:0051260; P:protein homooligomerization; IEA:EnsemblMetazoa. DR GO; GO:1903426; P:regulation of reactive oxygen species biosynthetic process; IEA:EnsemblMetazoa. DR GO; GO:0061041; P:regulation of wound healing; IEA:EnsemblMetazoa. DR InterPro; IPR006769; MCU_C. DR InterPro; IPR039055; MCU_fam. DR PANTHER; PTHR13462; CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL; 1. DR PANTHER; PTHR13462:SF10; CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL; 1. DR Pfam; PF04678; MCU; 1. PE 3: Inferred from homology; KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|RuleBase:RU367035}; KW Calcium channel {ECO:0000256|ARBA:ARBA00022673, KW ECO:0000256|RuleBase:RU367035}; KW Calcium transport {ECO:0000256|ARBA:ARBA00022568, KW ECO:0000256|RuleBase:RU367035}; KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367035}; KW Ion transport {ECO:0000256|ARBA:ARBA00023065, KW ECO:0000256|RuleBase:RU367035}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367035}; KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128, KW ECO:0000256|RuleBase:RU367035}; KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792, KW ECO:0000256|RuleBase:RU367035}; KW Reference proteome {ECO:0000313|Proteomes:UP000006672}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU367035}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU367035}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367035}. FT TRANSMEM 215..234 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU367035" FT TRANSMEM 246..264 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU367035" FT DOMAIN 91..300 FT /note="Calcium uniporter protein C-terminal" FT /evidence="ECO:0000259|Pfam:PF04678" SQ SEQUENCE 347 AA; 40613 MW; 1BE8D3CF29BCA063 CRC64; MRCRWYSITG LLQQRQQHLQ IQLSTCYINL NNMHHLRRCS NDTTRGNLHI WCQSGLPLLE VPLPSRREIC QFTLKPISDT VSRFCKNIEC EDKGIEIVYV YSTSGNRIAG STLLKHLLLR GNFRLRINDF IYTVEVPSSK DVIANIMADG DVMQKFDGLR STIAPLYSIM NVEVYKAFQE RLLIEEYENV KAELKPLIQA KFKFDEFCRK RAQRILWLTL AAMGFQAGFL ARLTWWDYSW DVMEPITYFA THATLIASFA YYLYTNQYYN HNDHKKRAIS LYFHKKAAKS NFDISRFNEL QNVASSIKHD LKKLRDPLYQ HLPTARLASL LQESGKVQPR SFTKERS //