ID A0A0H5BN33_9HIV1 Unreviewed; 584 AA. AC A0A0H5BN33; DT 14-OCT-2015, integrated into UniProtKB/TrEMBL. DT 14-OCT-2015, sequence version 1. DT 02-DEC-2020, entry version 24. DE RecName: Full=Protease {ECO:0000256|ARBA:ARBA00016591}; DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493}; DE EC=3.1.26.13 {ECO:0000256|ARBA:ARBA00012478}; DE AltName: Full=Retropepsin {ECO:0000256|ARBA:ARBA00019041}; DE Flags: Fragment; OS HIV-1 M:CRF08_BC. OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes; OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus. OX NCBI_TaxID=1385608 {ECO:0000313|EMBL:CDG41821.1}; RN [1] {ECO:0000313|EMBL:CDG41821.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=YN254 {ECO:0000313|EMBL:CDG41821.1}; RA Chen S., Chen Y.Y., Lu W.; RT "Changing subtype dominance and shift in resistance of HIV-1 in the RT southwest border of China."; RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the retroviral Pol polyprotein family. CC {ECO:0000256|RuleBase:RU004064}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HG421589; CDG41821.1; -; Genomic_RNA. DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW. DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW. DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW. DR CDD; cd05482; HIV_retropepsin_like; 1. DR Gene3D; 2.40.70.10; -; 1. DR Gene3D; 3.30.70.270; -; 3. DR InterPro; IPR001969; Aspartic_peptidase_AS. DR InterPro; IPR043502; DNA/RNA_pol_sf. DR InterPro; IPR001995; Peptidase_A2_cat. DR InterPro; IPR021109; Peptidase_aspartic_dom_sf. DR InterPro; IPR034170; Retropepsin-like_cat_dom. DR InterPro; IPR018061; Retropepsins. DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase. DR InterPro; IPR000477; RT_dom. DR InterPro; IPR010659; RVT_connect. DR InterPro; IPR010661; RVT_thumb. DR Pfam; PF00077; RVP; 1. DR Pfam; PF00078; RVT_1; 1. DR Pfam; PF06815; RVT_connect; 1. DR Pfam; PF06817; RVT_thumb; 1. DR SUPFAM; SSF50630; SSF50630; 1. DR SUPFAM; SSF56672; SSF56672; 1. DR PROSITE; PS50175; ASP_PROT_RETROV; 1. DR PROSITE; PS00141; ASP_PROTEASE; 1. DR PROSITE; PS50878; RT_POL; 1. PE 3: Inferred from homology; KW Aspartyl protease {ECO:0000256|ARBA:ARBA00022750, KW ECO:0000256|RuleBase:RU004064}; KW DNA integration {ECO:0000256|ARBA:ARBA00023195}; KW DNA recombination {ECO:0000256|ARBA:ARBA00023172}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW Endonuclease {ECO:0000256|ARBA:ARBA00022759}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU004064}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Nuclease {ECO:0000256|ARBA:ARBA00022722}; KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695}; KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU004064}; KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}; KW Viral genome integration {ECO:0000256|ARBA:ARBA00023195}; KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}. FT DOMAIN 72..141 FT /note="Peptidase A2" FT /evidence="ECO:0000259|PROSITE:PS50175" FT DOMAIN 195..385 FT /note="Reverse transcriptase" FT /evidence="ECO:0000259|PROSITE:PS50878" FT REGION 1..48 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 21..48 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:CDG41821.1" FT NON_TER 584 FT /evidence="ECO:0000313|EMBL:CDG41821.1" SQ SEQUENCE 584 AA; 67204 MW; 82ACDA6F31FF5E9F CRC64; FFRENLACPQ GEAREFPPEQ TRANSPASRE LQVRGDNPSS EAGTERQGTL NFPQITLWQR PLVSIKIGGQ IKEALLDTGA DDTVLEEINL PGKWKPKMIG GIGGFIKVRQ YEQIPIEICG KRATGTVLVG PTPVNIIGRN MLTQLGCTLN FPISPIETVP VKLKPGMDGP KVKQWPLTEE KIKALTAICD EMEKEGKITK IGPDNPYNTP IFAIKKKDST KWRKLVDFRE LNKRTQDFWE VQLGIPHPAG LKKKRSVTVL DVGDAYFSVP LDKDFRKYTA FTIPSINNAT PGIRYQYNVL PQGWKGSPAI FQCSMTKILE PFRKQNPDIV IYQYMDDLYV GSDLEIGQHR TKIEELREHL LKWGFTTPDK KHQKEPPFLW MGYELHPDKW TVQPIQLPDK DSWTVNDIQK LVGKLNWASQ IYPGIKVRQL CRLLRGAKAL TDIVPLTEEA ELELAENREI LKEPVHGAYY DPSKELIAEI QKQGQDQWTY QIYQEPFKNL KTGKYAKMRT AHTNDVKQLT EAVQKISMES IVIWGKIPKF RLPIQKETWE TWWTDYWQAT WIPEWEFVNT PPLVKLWYQL EKDP //