ID A0A0H3BY35_STRPZ Unreviewed; 805 AA. AC A0A0H3BY35; DT 16-SEP-2015, integrated into UniProtKB/TrEMBL. DT 16-SEP-2015, sequence version 1. DT 02-JUN-2021, entry version 18. DE SubName: Full=Extracellular hyaluronate lyase {ECO:0000313|EMBL:ACI61121.1}; GN Name=hylA {ECO:0000313|EMBL:ACI61121.1}; GN OrderedLocusNames=Spy49_0811c {ECO:0000313|EMBL:ACI61121.1}; OS Streptococcus pyogenes serotype M49 (strain NZ131). OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; OC Streptococcus. OX NCBI_TaxID=471876 {ECO:0000313|EMBL:ACI61121.1, ECO:0000313|Proteomes:UP000001039}; RN [1] {ECO:0000313|EMBL:ACI61121.1, ECO:0000313|Proteomes:UP000001039} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NZ131 {ECO:0000313|EMBL:ACI61121.1, RC ECO:0000313|Proteomes:UP000001039}; RX PubMed=18820018; DOI=10.1128/JB.00672-08; RA McShan W.M., Ferretti J.J., Karasawa T., Suvorov A.N., Lin S., Qin B., RA Jia H., Kenton S., Najar F., Wu H., Scott J., Roe B.A., Savic D.J.; RT "Genome sequence of a nephritogenic and highly transformable M49 strain of RT Streptococcus pyogenes."; RL J. Bacteriol. 190:7773-7785(2008). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000829; ACI61121.1; -; Genomic_DNA. DR RefSeq; WP_012560668.1; NC_011375.1. DR EnsemblBacteria; ACI61121; ACI61121; Spy49_0811c. DR KEGG; soz:Spy49_0811c; -. DR HOGENOM; CLU_004172_5_1_9; -. DR OMA; SENYWAT; -. DR Proteomes; UP000001039; Chromosome. DR GO; GO:0005576; C:extracellular region; IEA:InterPro. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro. DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW. DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro. DR Gene3D; 1.50.10.100; -; 1. DR Gene3D; 2.60.220.10; -; 1. DR Gene3D; 2.70.98.10; -; 1. DR InterPro; IPR008929; Chondroitin_lyas. DR InterPro; IPR011013; Gal_mutarotase_sf_dom. DR InterPro; IPR014718; GH-type_carb-bd. DR InterPro; IPR038970; Lyase_8. DR InterPro; IPR011071; Lyase_8-like_C. DR InterPro; IPR012970; Lyase_8_alpha_N. DR InterPro; IPR003159; Lyase_8_central_dom. DR PANTHER; PTHR38481; PTHR38481; 1. DR Pfam; PF02278; Lyase_8; 1. DR Pfam; PF08124; Lyase_8_N; 1. DR SUPFAM; SSF48230; SSF48230; 1. DR SUPFAM; SSF74650; SSF74650; 1. PE 4: Predicted; KW Lyase {ECO:0000313|EMBL:ACI61121.1}; Membrane {ECO:0000256|SAM:Phobius}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 12..33 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 77..422 FT /note="Lyase_8_N" FT /evidence="ECO:0000259|Pfam:PF08124" FT DOMAIN 466..737 FT /note="Lyase_8" FT /evidence="ECO:0000259|Pfam:PF02278" SQ SEQUENCE 805 AA; 92409 MW; 88C38CCDE9FB2AC5 CRC64; MNTYFCTHHK QLLLYSNLFL SFAMIGQGTA IYADTLTSNS EPNNTYFQTQ TLTTTDSEKK VVQPQQKDYY TELLDQWNSI ISGNDAYDKT NPDMVTFHNK AEKDAQNIIK SYQGPDHENR TYLWEHAKDY SAAANITKTY RNIEKIAKQI TNPESCYYQD SKAIAIVKDG MAFMYEHAYN LDRENHQTTG KENKENWWVY EIGTPRAINN TLSLMYPYFT QEEILKYTAP IEKFVPDPTR FRVCAANFSP FEANSGNLID MGRVKLISGI LRKDDLEISD TIKAIEKVFT LVDEGNGFYQ DGSLIDHVVT NAQSPLYKKG IAYTGAYGNV LIDGLSQLIP IIQKTKSPIE ADKMATIYHW INHSFFPIIV RGEMMDMTRG RSISRFNAQS HVAGIEALRA ILRIADMSEE PHRLALKTRI KTLVTQGNAF YNVYDNLKTY HDIKLMKELL SDTSVPVQKL DSYVASFNSM DKLALYNNKH DFAFGLSMFS NRTQNYEAMN NENLHGWFTS DGMFYLYNND LGHYSENYWA TVNPYRLPGT TETEQKPLEG TPENIKTNYQ QVGMTSLSDD AFVASKKLNN TSALAAMTFT NWNKSLTLNK GWFILGNKII FVGSNIKNQS SHKAYTTIEQ RKENQKHPYC SYVNNQPVDL NNQLVDFTNT KSIFLESDDP AQNIGYYFFK PTTLSISKAL QTGKWQNIKA DDKSPEAIKE VSNTFITITQ NHTQDGDRYA YMMLPNMTRQ EFETYISKLD IDLLENNDKL AAVYDHDSQQ MHVIHYEKKA TMFSNHNLSH QGFYSFPHPV KQNQQ //