ID A0A0H2WR55_SALPA Unreviewed; 170 AA. AC A0A0H2WR55; DT 16-SEP-2015, integrated into UniProtKB/TrEMBL. DT 16-SEP-2015, sequence version 1. DT 24-JAN-2024, entry version 29. DE RecName: Full=4-hydroxyphenylacetate 3-monooxygenase reductase component {ECO:0000256|ARBA:ARBA00015398}; DE EC=1.5.1.36 {ECO:0000256|ARBA:ARBA00013272}; DE AltName: Full=4-HPA 3-monooxygenase small component {ECO:0000256|ARBA:ARBA00032609}; DE AltName: Full=Flavin:NADH reductase {ECO:0000256|ARBA:ARBA00031872}; GN Name=hpaC {ECO:0000313|EMBL:AAV77671.1}; GN OrderedLocusNames=SPA1752 {ECO:0000313|EMBL:AAV77671.1}; GN ORFNames=GNB70_001947 {ECO:0000313|EMBL:HAE6986290.1}; OS Salmonella paratyphi A (strain ATCC 9150 / SARB42). OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Salmonella. OX NCBI_TaxID=295319 {ECO:0000313|EMBL:AAV77671.1, ECO:0000313|Proteomes:UP000008185}; RN [1] {ECO:0000313|EMBL:AAV77671.1, ECO:0000313|Proteomes:UP000008185} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 9150 {ECO:0000313|EMBL:AAV77671.1}, and ATCC 9150 / SARB42 RC {ECO:0000313|Proteomes:UP000008185}; RX PubMed=15531882; DOI=10.1038/ng1470; RA McClelland M., Sanderson K.E., Clifton S.W., Latreille P., Porwollik S., RA Sabo A., Meyer R., Bieri T., Ozersky P., McLellan M., Harkins C.R., RA Wang C., Nguyen C., Berghoff A., Elliott G., Kohlberg S., Strong C., Du F., RA Carter J., Kremizki C., Layman D., Leonard S., Sun H., Fulton L., Nash W., RA Miner T., Minx P., Delehaunty K., Fronick C., Magrini V., Nhan M., RA Warren W., Florea L., Spieth J., Wilson R.K.; RT "Comparison of genome degradation in Paratyphi A and Typhi, human- RT restricted serovars of Salmonella enterica that cause typhoid."; RL Nat. Genet. 36:1268-1274(2004). RN [2] {ECO:0000313|EMBL:HAE6986290.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ATCC 9150 {ECO:0000313|EMBL:HAE6986290.1}; RX PubMed=30286803; RA Souvorov A., Agarwala R., Lipman D.J.; RT "SKESA: strategic k-mer extension for scrupulous assemblies."; RL Genome Biol. 19:153-153(2018). RN [3] {ECO:0000313|EMBL:HAE6986290.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ATCC 9150 {ECO:0000313|EMBL:HAE6986290.1}; RG NCBI Pathogen Detection Project; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes the reduction of free flavins (FMN, FAD and CC riboflavin) by NADH. Subsequently, the reduced flavins diffuse to the CC large HpaB component or to other electron acceptors such as cytochrome CC c and Fe(3+) ion. {ECO:0000256|ARBA:ARBA00025117}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a reduced flavin + NAD(+) = an oxidized flavin + 2 H(+) + CC NADH; Xref=Rhea:RHEA:31303, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, CC ChEBI:CHEBI:57945, ChEBI:CHEBI:60531, ChEBI:CHEBI:62787; EC=1.5.1.36; CC Evidence={ECO:0000256|ARBA:ARBA00001377}; CC -!- PATHWAY: Aromatic compound metabolism; 4-hydroxyphenylacetate CC degradation; pyruvate and succinate semialdehyde from 4- CC hydroxyphenylacetate: step 1/7. {ECO:0000256|ARBA:ARBA00005112}. CC -!- SIMILARITY: Belongs to the non-flavoprotein flavin reductase family. CC HpaC subfamily. {ECO:0000256|ARBA:ARBA00006032}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000026; AAV77671.1; -; Genomic_DNA. DR EMBL; DAASTS010000008; HAE6986290.1; -; Genomic_DNA. DR RefSeq; WP_001195556.1; NC_006511.1. DR AlphaFoldDB; A0A0H2WR55; -. DR SMR; A0A0H2WR55; -. DR KEGG; spt:SPA1752; -. DR HOGENOM; CLU_059021_2_2_6; -. DR OMA; CINVLPA; -. DR UniPathway; UPA00208; UER00416. DR Proteomes; UP000008185; Chromosome. DR GO; GO:0036382; F:flavin reductase (NADH) activity; IEA:UniProtKB-EC. DR GO; GO:0010181; F:FMN binding; IEA:InterPro. DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW. DR GO; GO:0051287; F:NAD binding; IEA:InterPro. DR GO; GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IEA:InterPro. DR GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW. DR GO; GO:0042537; P:benzene-containing compound metabolic process; IEA:InterPro. DR InterPro; IPR002563; Flavin_Rdtase-like_dom. DR InterPro; IPR011982; HPA_mOase_red. DR InterPro; IPR012349; Split_barrel_FMN-bd. DR NCBIfam; TIGR02296; HpaC; 1. DR PANTHER; PTHR30466; FLAVIN REDUCTASE; 1. DR PANTHER; PTHR30466:SF1; FMN REDUCTASE (NADH) RUTF; 1. DR Pfam; PF01613; Flavin_Reduct; 1. DR SMART; SM00903; Flavin_Reduct; 1. DR SUPFAM; SSF50475; FMN-binding split barrel; 1. PE 3: Inferred from homology; KW Aromatic hydrocarbons catabolism {ECO:0000256|ARBA:ARBA00022797}; KW Monooxygenase {ECO:0000313|EMBL:HAE6986290.1}; KW Oxidoreductase {ECO:0000313|EMBL:HAE6986290.1}. FT DOMAIN 14..161 FT /note="Flavin reductase like" FT /evidence="ECO:0000259|SMART:SM00903" SQ SEQUENCE 170 AA; 18481 MW; D6952B6942A3C217 CRC64; MQVDEQRLRF RDAMASLAAA VNIVTTAGHA GRCGITATAV CSVTDTPPSV MVCINANSAM NPVFQGNGRL CINVLNHEQE LMARHFAGMT GMAMEERFHQ PCWQNGPLGQ PVLNGALAGL EGEISEVQTI GTHLVYLVAI KNIILSQDGH GLIYFKRRFH PVRLEMEAPV //