ID   A0A0G3Z801_PIG          Unreviewed;       255 AA.
AC   A0A0G3Z801;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   22-FEB-2023, entry version 23.
DE   SubName: Full=MHC class II antigen {ECO:0000313|EMBL:AKM45919.1};
GN   Name=SLA-DQA {ECO:0000313|EMBL:AKM45919.1};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|EMBL:AKM45919.1};
RN   [1] {ECO:0000313|EMBL:AKM45919.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25049886; DOI=10.5713/ajas.2013.13067;
RA   Yang Q.L., Kong J.J., Wang D.W., Zhao S.G., Gun S.B.;
RT   "Swine Leukocyte Antigen-DQA Gene Variation and Its Association with Piglet
RT   Diarrhea in Large White, Landrace and Duroc.";
RL   Asian-Australas. J. Anim. Sci. 26:1065-1071(2013).
RN   [2] {ECO:0000313|EMBL:AKM45919.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Yang Q., Kong J., Huang X., Liu L., Zhao S., Gun S.;
RT   "Effect of genetic variation in the swine leukocyte antigen-DQA gene on
RT   diarrhea in Large White, Landrace and Duroc piglets.";
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the MHC class II family.
CC       {ECO:0000256|RuleBase:RU004238}.
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DR   EMBL; KT031064; AKM45919.1; -; mRNA.
DR   AlphaFoldDB; A0A0G3Z801; -.
DR   GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0002504; P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:UniProtKB-KW.
DR   CDD; cd05767; IgC_MHC_II_alpha; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR014745; MHC_II_a/b_N.
DR   InterPro; IPR001003; MHC_II_a_N.
DR   PANTHER; PTHR19944:SF59; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ ALPHA 1 CHAIN; 1.
DR   PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00993; MHC_II_alpha; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SMART; SM00920; MHC_II_alpha; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   2: Evidence at transcript level;
KW   Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Membrane {ECO:0000256|SAM:Phobius}; MHC II {ECO:0000256|ARBA:ARBA00023182};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..255
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5005186346"
FT   TRANSMEM        222..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          113..193
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
SQ   SEQUENCE   255 AA;  28011 MW;  DC3C7080E02BAF1C CRC64;
     MVPGRVLMWG ALALTAVMSA CGGEDIAADH VASYGLNVYQ SYGSSGYYTH EFDGDEQFYV
     DLEKKETVWQ LPLFSKFTSF DPQSALRNIA VGKLTLNILT KRSNNTAAVN KVPEVTVFSK
     SPVILGQPNT LICHVDSIFP PVINITWLKN GHSVTEGFSE TSFLSRNDHS FLKISYLTFL
     PSDDDFYDCK VEHWGLDKPL LKHWEPEIPA PMSELTETVV CALGLIVGLV GIVVGTVFII
     QGLRSGGPSR HQGSL
//