ID A0A0G3EL70_9NEOB Unreviewed; 199 AA. AC A0A0G3EL70; DT 16-SEP-2015, integrated into UniProtKB/TrEMBL. DT 16-SEP-2015, sequence version 1. DT 22-FEB-2023, entry version 16. DE SubName: Full=Tyrosinase {ECO:0000313|EMBL:AKJ66712.1}; DE Flags: Fragment; OS Papurana waliesa. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; OC Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Papurana. OX NCBI_TaxID=1659780 {ECO:0000313|EMBL:AKJ66712.1}; RN [1] {ECO:0000313|EMBL:AKJ66712.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=25987527; DOI=10.1016/j.ympev.2015.05.001; RA Oliver L.A., Prendini E., Kraus F., Raxworthy C.J.; RT "Systematics and biogeography of the Hylarana frog (Anura: Ranidae) RT radiation across tropical Australasia, Southeast Asia, and Africa."; RL Mol. Phylogenet. Evol. 90:176-192(2015). CC -!- SUBCELLULAR LOCATION: Melanosome membrane CC {ECO:0000256|ARBA:ARBA00004573}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004573}. CC -!- SIMILARITY: Belongs to the tyrosinase family. CC {ECO:0000256|ARBA:ARBA00009928}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KR264445; AKJ66712.1; -; Genomic_DNA. DR AlphaFoldDB; A0A0G3EL70; -. DR GO; GO:0033162; C:melanosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro. DR GO; GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW. DR CDD; cd00055; EGF_Lam; 1. DR Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1. DR InterPro; IPR008922; Di-copper_centre_dom_sf. DR InterPro; IPR002049; LE_dom. DR InterPro; IPR002227; Tyrosinase_Cu-bd. DR PANTHER; PTHR11474:SF124; TYROSINASE; 1. DR PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1. DR Pfam; PF00264; Tyrosinase; 1. DR SUPFAM; SSF48056; Di-copper centre-containing domain; 1. DR PROSITE; PS00497; TYROSINASE_1; 1. PE 3: Inferred from homology; KW Melanin biosynthesis {ECO:0000256|ARBA:ARBA00023101}. FT DOMAIN 167..184 FT /note="Tyrosinase copper-binding" FT /evidence="ECO:0000259|PROSITE:PS00497" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AKJ66712.1" FT NON_TER 199 FT /evidence="ECO:0000313|EMBL:AKJ66712.1" SQ SEQUENCE 199 AA; 22763 MW; 20BEB3E975FD3362 CRC64; CPIWPGDNSS CGEISGRGVC QDVVPSNAPV GAQFPFSGID DRENWPIVFY NRTCQCQGNF TGYNCGECRF GYTGPNCTVR RNMIRKEIFR MTTAEKDKFI AYLNLAKRTI SPDYVIATGT YEQMNNGSNP MFADINVYDL FVWLHYYASR DAFLEDGSVW ANIDFAHEAP GFLPWHRFFL LLWEREIQKV TGDDNFTIP //