ID   A0A0G3AHC5_9ACTN        Unreviewed;       334 AA.
AC   A0A0G3AHC5;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   14-DEC-2022, entry version 18.
DE   SubName: Full=Dehydrogenase {ECO:0000313|EMBL:AKJ13411.1};
GN   ORFNames=ABB07_26290 {ECO:0000313|EMBL:AKJ13411.1};
OS   Streptomyces incarnatus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=665007 {ECO:0000313|EMBL:AKJ13411.1, ECO:0000313|Proteomes:UP000035366};
RN   [1] {ECO:0000313|EMBL:AKJ13411.1, ECO:0000313|Proteomes:UP000035366}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL8089 {ECO:0000313|Proteomes:UP000035366};
RX   PubMed=26159526;
RA   Oshima K., Hattori M., Shimizu H., Fukuda K., Nemoto M., Inagaki K.,
RA   Tamura T.;
RT   "Draft Genome Sequence of Streptomyces incarnatus NRRL8089, which Produces
RT   the Nucleoside Antibiotic Sinefungin.";
RL   Genome Announc. 3:e00715-e00715(2015).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU361277}.
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DR   EMBL; CP011497; AKJ13411.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0G3AHC5; -.
DR   STRING; 665007.ABB07_26290; -.
DR   EnsemblBacteria; AKJ13411; AKJ13411; ABB07_26290.
DR   PATRIC; fig|665007.5.peg.5583; -.
DR   Proteomes; UP000035366; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035366};
KW   Zinc {ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          11..332
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   334 AA;  34575 MW;  27497F633B2E927A CRC64;
     MSTAVVVEAP GRHRLVAHTP REPGPGEALV AVHAVGICGS DREVYQGNRP EGYVRYPLTP
     GHEWSGTVSE VGAGVPAGLV GRKVVGEGFR NCQVCDRCHA GETTLCTDGY EETGFTQPGA
     MAGTLTLPAR LLHVLPDDAD LTAAALLEPA ACVAAAALKA RALPGERVAV VGTGTLGMFA
     VQFLKAVSPA ELLVVGTGND REALARRFGA TGFRLKDQEL PDDMDVVIET AGSASAARTA
     AALLRRGGRL VLTGIPAPGA DGLDPTDLVV RQLEVHTVFG APPDAWAHTV RVFGAGLLDP
     LPLVTHELPL TGFPQAIELV GAGDPKVGKV LLRP
//