ID   A0A0G2QS48_9INFA        Unreviewed;       469 AA.
AC   A0A0G2QS48;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   05-JUL-2017, entry version 17.
DE   RecName: Full=Neuraminidase {ECO:0000256|RuleBase:RU361252, ECO:0000256|SAAS:SAAS00114532};
DE            EC=3.2.1.18 {ECO:0000256|RuleBase:RU361252, ECO:0000256|SAAS:SAAS00114514};
GN   Name=NA {ECO:0000256|RuleBase:RU361252, ECO:0000313|EMBL:AHA57022.1};
OS   Influenza A virus (A/Chinese francolin/Guangxi/B7/2010(H9N2)).
OC   Viruses; ssRNA viruses; ssRNA negative-strand viruses;
OC   Orthomyxoviridae; Influenzavirus A.
OX   NCBI_TaxID=1413193 {ECO:0000313|EMBL:AHA57022.1, ECO:0000313|Proteomes:UP000110745};
RN   [1] {ECO:0000313|EMBL:AHA57022.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A/Chinese francolin/Guangxi/B7/2010
RC   {ECO:0000313|EMBL:AHA57022.1};
RA   Peng Y., Xie Z., Liu J., Pang Y., Xie Z., Xie L., Luo S., Fan Q.;
RT   "Genetic analysis of H9 subtype avian influenza viruses in Guangxi,
RT   Southern China during 2005 to 2010.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-,
CC       alpha-(2->8)- glycosidic linkages of terminal sialic acid residues
CC       in oligosaccharides, glycoproteins, glycolipids, colominic acid
CC       and synthetic substrates. {ECO:0000256|RuleBase:RU361252,
CC       ECO:0000256|SAAS:SAAS00114528}.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|RuleBase:RU361252,
CC         ECO:0000256|SAAS:SAAS00610656};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|RuleBase:RU361252,
CC       ECO:0000256|SAAS:SAAS00114476}.
CC   -!- SUBCELLULAR LOCATION: Host apical cell membrane
CC       {ECO:0000256|SAAS:SAAS00561320}; Single-pass type II membrane
CC       protein {ECO:0000256|SAAS:SAAS00561320}.
CC   -!- PTM: N-glycosylated. {ECO:0000256|RuleBase:RU361252}.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 34 family.
CC       {ECO:0000256|RuleBase:RU361252, ECO:0000256|SAAS:SAAS00561099}.
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DR   EMBL; KF768204; AHA57022.1; -; Viral_cRNA.
DR   Proteomes; UP000110745; Genome.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0046761; P:viral budding from plasma membrane; IEA:InterPro.
DR   CDD; cd15483; Influenza_NA; 1.
DR   InterPro; IPR001860; Glyco_hydro_34.
DR   InterPro; IPR033654; Sialidase_Influenza_A/B.
DR   InterPro; IPR011040; Sialidases.
DR   Pfam; PF00064; Neur; 1.
DR   SUPFAM; SSF50939; SSF50939; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU361252,
KW   ECO:0000256|SAAS:SAAS00062903};
KW   Complete proteome {ECO:0000313|Proteomes:UP000110745};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00063019};
KW   Glycoprotein {ECO:0000256|RuleBase:RU361252};
KW   Glycosidase {ECO:0000256|RuleBase:RU361252,
KW   ECO:0000256|SAAS:SAAS00062426};
KW   Host cell membrane {ECO:0000256|RuleBase:RU361252,
KW   ECO:0000256|SAAS:SAAS00062854};
KW   Host membrane {ECO:0000256|RuleBase:RU361252,
KW   ECO:0000256|SAAS:SAAS00114565};
KW   Hydrolase {ECO:0000256|RuleBase:RU361252,
KW   ECO:0000256|SAAS:SAAS00114491};
KW   Membrane {ECO:0000256|SAAS:SAAS00114461, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|RuleBase:RU361252,
KW   ECO:0000256|SAAS:SAAS00062292};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00114524,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00114517,
KW   ECO:0000256|SAM:Phobius};
KW   Virion {ECO:0000256|RuleBase:RU361252, ECO:0000256|SAAS:SAAS00114362}.
FT   TRANSMEM      7     30       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   469 AA;  51404 MW;  2CB026A3DAC928F0 CRC64;
     MNPNQKIVAI GSASLTIATM CLLLQIALFA TTMTLHFKQT GCTNSSDNQA VPCGPIIIER
     NTTEIVHLNS TTLEKETCPK SAGYRNWSKP QCQITGFAPF SKDNSIRLAA AGDIWVTREP
     YVSCGLGKCY QFALGQGTTL DNKHSNGTTH DRTPHRTLLM NELGVPFHLA TKQVCIAWSS
     SSCHDGKAWL HVCVTGDDKN ATASIIYDGI LVDSIASWSK NILRTQESEC VCINGTCTVV
     MTDGSASGRA DTRILFIREG KIVHISPLSG SAQHVEECSC YPRYPEVRCV CRDNWKGSNR
     PVLFINMADY SIDSSYVCSG LVGDTPRNDD RSSSSNCRDP NNERGAPGVK GWAFDSGNDI
     WMGRTIEKDS RSGYETFRVI GGWSTANSKS QINRQVIVDR DNSSGYSGIF SVEGKSCINR
     CFYVELIRGR PKENRVWWTS NSIIVFCGTS GTYGTGSWPD GANINLMPI
//