ID A0A0G2K5Y2_RAT Unreviewed; 992 AA. AC A0A0G2K5Y2; DT 25-MAY-2022, integrated into UniProtKB/TrEMBL. DT 25-MAY-2022, sequence version 1. DT 28-JUN-2023, entry version 7. DE SubName: Full=HECT and RLD domain containing E3 ubiquitin protein ligase 3 {ECO:0000313|Ensembl:ENSRNOP00000073603.2}; GN Name=Herc3 {ECO:0000313|Ensembl:ENSRNOP00000073603.2, GN ECO:0000313|RGD:1307803}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000073603.2, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000073603.2, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000073603.2, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., RA Mockrin S., Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into mammalian RT evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000073603.2} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000073603.2}; RG Ensembl; RL Submitted (MAR-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR STRING; 10116.ENSRNOP00000010241; -. DR Ensembl; ENSRNOT00000087451.2; ENSRNOP00000073603.2; ENSRNOG00000007304.7. DR AGR; RGD:1307803; -. DR RGD; 1307803; Herc3. DR eggNOG; KOG0941; Eukaryota. DR GeneTree; ENSGT00940000158189; -. DR HOGENOM; CLU_002173_5_3_1; -. DR Proteomes; UP000002494; Chromosome 4. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central. DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central. DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central. DR CDD; cd00078; HECTc; 1. DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1. DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1. DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1. DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 1. DR InterPro; IPR000569; HECT_dom. DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase. DR InterPro; IPR009091; RCC1/BLIP-II. DR InterPro; IPR000408; Reg_chr_condens. DR PANTHER; PTHR45622:SF18; E3 UBIQUITIN-PROTEIN LIGASE HERC3-RELATED; 1. DR PANTHER; PTHR45622; UBIQUITIN-PROTEIN LIGASE E3A-RELATED; 1. DR Pfam; PF00632; HECT; 1. DR Pfam; PF00415; RCC1; 5. DR PRINTS; PR00633; RCCNDNSATION. DR SMART; SM00119; HECTc; 1. DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1. DR SUPFAM; SSF50985; RCC1/BLIP-II; 1. DR PROSITE; PS50237; HECT; 1. DR PROSITE; PS00626; RCC1_2; 3. DR PROSITE; PS50012; RCC1_3; 5. PE 4: Predicted; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786, KW ECO:0000256|PROSITE-ProRule:PRU00104}. FT REPEAT 45..97 FT /note="RCC1" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235" FT REPEAT 98..150 FT /note="RCC1" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235" FT REPEAT 151..202 FT /note="RCC1" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235" FT REPEAT 203..254 FT /note="RCC1" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235" FT REPEAT 256..322 FT /note="RCC1" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235" FT DOMAIN 665..992 FT /note="HECT" FT /evidence="ECO:0000259|PROSITE:PS50237" FT ACT_SITE 960 FT /note="Glycyl thioester intermediate" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" SQ SEQUENCE 992 AA; 111298 MW; 51AC6952CD4A1EB5 CRC64; MDVWVQACDR YARVDWREQI GALADQHIIH VACGESHSLA LSDRGQLFSW GAGSDGQLGL MTTEDSVAVP RLIQKLNQQT ILQVSCGNWH CLALAADGQF FTWGKNSHGQ LGLGKEFPSQ TSPQRVRSLE GIPLAQVAAG GAHSFALSLS GAVFGWGMNN AGQLGLSDEK DRESPCHVKL LRTQKVVYIS CGEEHTAVLT KSGGVFTFGA GSCGQLGHDS VNDEVNPRRV LELMGSEVTQ IACGRQHTLA LVPSSGLIYA FGCGAKGQLG TGHTCNVKCP SPVKGHWAAH SGQLSARADR FKYRVVKQIF SGGDQTFVLC STYENSSPAV DFRTVNQAHY TNLINDETIA VWRQKLTEHN NANTVNGVVQ ILSSAACWNG SFLEKKIDEH FKTSPKIPGI DLNSTRVLFE KLMHSQHSMI LEQILNSFES CLIPQLSSSP PDVEAMRIYL ILPEFPLLQD SKYYITLTIP LAMAILRLET NPSKVLDNWW SQACPKYFMK LVTLYKSAVL YLLRGRKTFL IPVLFNNYMT ATLKLLEKLY KVNLKVKHVE YDKFYIPEIS SLVDIQEDYL MWFLHQSGMK ARPSIMQDAV TLCSYPFIFD AQAKTKMLQT DAELQMQVAV NGANLQNVFM LLTLEPLLAR SPFLVLHVRR NHLVGDALRE LSIHSDIDLK KPLKVIFDGE EGVDAGGVTK EFFLLLLKEL LNPIYGMFTY YQDSNLLWFS DTCFVEHNWF HLIGITCGLA IYNSTVVDLH FPLALYKKLL NVKPSLEDLK ELSPTEGRSL QELLDYPGED IEETFCLNFT VCRESYGVIE QKKLIPGGDR VAVCKDNRQE FVDAYVNYIF QISVHEWYTA FSSGFLKVCG GKVLELFQPA ELRAMMVGNS NYNWEELEET AVYKGDYSST HPTVKLFWET FHEFPLEKKK RFLLFLTGSD RIPIYGMASL QIVIQSTATG EDYLPVAHTC YNLLDLPKYS SKEIMKARLT QALDNYEGFS LA //