ID A0A0G2K5Y2_RAT Unreviewed; 992 AA. AC A0A0G2K5Y2; DT 25-MAY-2022, integrated into UniProtKB/TrEMBL. DT 25-MAY-2022, sequence version 1. DT 25-MAY-2022, entry version 1. DE SubName: Full=HECT and RLD domain-containing E3 ubiquitin protein ligase 3 {ECO:0000313|Ensembl:ENSRNOP00000073603}; GN Name=Herc3 {ECO:0000313|Ensembl:ENSRNOP00000073603, GN ECO:0000313|RGD:1307803}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000073603, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000073603, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000073603, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., RA Mockrin S., Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into mammalian RT evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000073603} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000073603}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; NP_001102101.1; NM_001108631.1. DR RefSeq; XP_006236646.1; XM_006236584.3. DR RefSeq; XP_017448177.1; XM_017592688.1. DR STRING; 10116.ENSRNOP00000010241; -. DR Ensembl; ENSRNOT00000087451.2; ENSRNOP00000073603.2; ENSRNOG00000007304.7. DR GeneID; 362377; -. DR KEGG; rno:362377; -. DR CTD; 8916; -. DR RGD; 1307803; Herc3. DR eggNOG; KOG0941; Eukaryota. DR GeneTree; ENSGT00940000158189; -. DR HOGENOM; CLU_002173_5_3_1; -. DR OMA; CELMAMV; -. DR OrthoDB; 1062377at2759; -. DR Reactome; R-RNO-983168; Antigen processing: Ubiquitination & Proteasome degradation. DR Proteomes; UP000002494; Chromosome 4. DR Bgee; ENSRNOG00000007304; Expressed in brain and 21 other tissues. DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro. DR CDD; cd00078; HECTc; 1. DR Gene3D; 2.130.10.30; -; 2. DR InterPro; IPR000569; HECT_dom. DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase. DR InterPro; IPR009091; RCC1/BLIP-II. DR InterPro; IPR000408; Reg_chr_condens. DR Pfam; PF00632; HECT; 1. DR Pfam; PF00415; RCC1; 6. DR PRINTS; PR00633; RCCNDNSATION. DR SMART; SM00119; HECTc; 1. DR SUPFAM; SSF50985; SSF50985; 1. DR SUPFAM; SSF56204; SSF56204; 1. DR PROSITE; PS50237; HECT; 1. DR PROSITE; PS00626; RCC1_2; 4. DR PROSITE; PS50012; RCC1_3; 7. PE 4: Predicted; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}. SQ SEQUENCE 992 AA; 111298 MW; 51AC6952CD4A1EB5 CRC64; MDVWVQACDR YARVDWREQI GALADQHIIH VACGESHSLA LSDRGQLFSW GAGSDGQLGL MTTEDSVAVP RLIQKLNQQT ILQVSCGNWH CLALAADGQF FTWGKNSHGQ LGLGKEFPSQ TSPQRVRSLE GIPLAQVAAG GAHSFALSLS GAVFGWGMNN AGQLGLSDEK DRESPCHVKL LRTQKVVYIS CGEEHTAVLT KSGGVFTFGA GSCGQLGHDS VNDEVNPRRV LELMGSEVTQ IACGRQHTLA LVPSSGLIYA FGCGAKGQLG TGHTCNVKCP SPVKGHWAAH SGQLSARADR FKYRVVKQIF SGGDQTFVLC STYENSSPAV DFRTVNQAHY TNLINDETIA VWRQKLTEHN NANTVNGVVQ ILSSAACWNG SFLEKKIDEH FKTSPKIPGI DLNSTRVLFE KLMHSQHSMI LEQILNSFES CLIPQLSSSP PDVEAMRIYL ILPEFPLLQD SKYYITLTIP LAMAILRLET NPSKVLDNWW SQACPKYFMK LVTLYKSAVL YLLRGRKTFL IPVLFNNYMT ATLKLLEKLY KVNLKVKHVE YDKFYIPEIS SLVDIQEDYL MWFLHQSGMK ARPSIMQDAV TLCSYPFIFD AQAKTKMLQT DAELQMQVAV NGANLQNVFM LLTLEPLLAR SPFLVLHVRR NHLVGDALRE LSIHSDIDLK KPLKVIFDGE EGVDAGGVTK EFFLLLLKEL LNPIYGMFTY YQDSNLLWFS DTCFVEHNWF HLIGITCGLA IYNSTVVDLH FPLALYKKLL NVKPSLEDLK ELSPTEGRSL QELLDYPGED IEETFCLNFT VCRESYGVIE QKKLIPGGDR VAVCKDNRQE FVDAYVNYIF QISVHEWYTA FSSGFLKVCG GKVLELFQPA ELRAMMVGNS NYNWEELEET AVYKGDYSST HPTVKLFWET FHEFPLEKKK RFLLFLTGSD RIPIYGMASL QIVIQSTATG EDYLPVAHTC YNLLDLPKYS SKEIMKARLT QALDNYEGFS LA //