ID   A0A0F7KLS3_9VIRU        Unreviewed;       173 AA.
AC   A0A0F7KLS3;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   02-OCT-2024, entry version 17.
DE   RecName: Full=RNA-directed RNA polymerase L {ECO:0000256|ARBA:ARBA00018602};
DE            EC=2.7.7.48 {ECO:0000256|ARBA:ARBA00012494};
DE   AltName: Full=Large structural protein {ECO:0000256|ARBA:ARBA00030285};
DE   Flags: Fragment;
OS   Cache Valley virus.
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Ellioviricetes; Bunyavirales; Peribunyaviridae; Orthobunyavirus;
OC   Orthobunyavirus cacheense.
OX   NCBI_TaxID=80935 {ECO:0000313|EMBL:AKH40421.1};
RN   [1] {ECO:0000313|EMBL:AKH40421.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=10767 {ECO:0000313|EMBL:AKH40421.1};
RX   PubMed=25962774; DOI=10.4269/ajtmh.15-0132;
RA   Armstrong P.M., Andreadis T.G., Anderson J.F.;
RT   "Emergence of a New Lineage of Cache Valley Virus (Bunyaviridae:
RT   Orthobunyavirus) in the Northeastern United States.";
RL   Am. J. Trop. Med. Hyg. 93:11-17(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000256|ARBA:ARBA00024517};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
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DR   EMBL; KP835806; AKH40421.1; -; Viral_cRNA.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.91.60; -; 1.
DR   InterPro; IPR048006; CapSnatch_bunyavir.
DR   InterPro; IPR029124; L_protein_N.
DR   NCBIfam; TIGR04202; capSnatchArena; 1.
DR   Pfam; PF15518; L_protein_N; 1.
PE   4: Predicted;
KW   Nucleotidyltransferase {ECO:0000313|EMBL:AKH40421.1};
KW   RNA-directed RNA polymerase {ECO:0000313|EMBL:AKH40421.1};
KW   Transferase {ECO:0000313|EMBL:AKH40421.1}.
FT   DOMAIN          6..173
FT                   /note="RNA-directed RNA polymerase L N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF15518"
FT   NON_TER         173
FT                   /evidence="ECO:0000313|EMBL:AKH40421.1"
SQ   SEQUENCE   173 AA;  19897 MW;  14138909EFDB3846 CRC64;
     MEDQMHDQFL KRIQSAKTAT VAKDISTDIL EARHDYFGRE LCASIGIEFR NNVLLDEIIL
     DVAPGINLMN FNIPNVTPDN YIWDDDFLII MDYKVSVGND STEITYKKYT TLILPVMEQI
     GIPTEIAIIR ANPVTYQISI IGENFKAKYP NIPIQLDFSK FFELRKLLLD KFA
//