ID A0A0E3UR62_9ANNE Unreviewed; 185 AA. AC A0A0E3UR62; DT 24-JUN-2015, integrated into UniProtKB/TrEMBL. DT 24-JUN-2015, sequence version 1. DT 11-DEC-2019, entry version 18. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 2 {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00093744}; DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS01109717}; DE Flags: Fragment; GN Name=ND2 {ECO:0000313|EMBL:AKC91565.1}; OS Satchellius mammalis. OG Mitochondrion {ECO:0000313|EMBL:AKC91565.1}. OC Eukaryota; Metazoa; Lophotrochozoa; Annelida; Clitellata; Oligochaeta; OC Haplotaxida; Lumbricina; Lumbricidae; Lumbricinae; Satchellius. OX NCBI_TaxID=1150272 {ECO:0000313|EMBL:AKC91565.1}; RN [1] {ECO:0000313|EMBL:AKC91565.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Nephridia {ECO:0000313|EMBL:AKC91565.1}; RX PubMed=26074907; DOI=10.3389/fmicb.2015.00529; RA Moller P., Lund M.B., Schramm A.; RT "Evolution of the tripartite symbiosis between earthworms, RT Verminephrobacter and Flexibacter-like bacteria."; RL Front. Microbiol. 6:529-529(2015). RN [2] {ECO:0000313|EMBL:AKC91565.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Nephridia {ECO:0000313|EMBL:AKC91565.1}; RA Pelicic Vladimir; RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) that is believed to belong to the CC minimal assembly required for catalysis. Complex I functions in the CC transfer of electrons from NADH to the respiratory chain. The immediate CC electron acceptor for the enzyme is believed to be ubiquinone. CC {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00093760}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000256|RuleBase:RU003403, CC ECO:0000256|SAAS:SAAS01125045}; CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00387338}; Multi- CC pass membrane protein {ECO:0000256|RuleBase:RU003403, CC ECO:0000256|SAAS:SAAS00387338}. CC -!- SIMILARITY: Belongs to the complex I subunit 2 family. CC {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00573211}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KP420679; AKC91565.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro. DR InterPro; IPR003917; NADH_UbQ_OxRdtase_chain2. DR InterPro; IPR001750; ND/Mrp_mem. DR Pfam; PF00361; Proton_antipo_M; 1. DR PRINTS; PR01436; NADHDHGNASE2. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00093681}; KW Membrane {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00464716}; KW Mitochondrion {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00093699, ECO:0000313|EMBL:AKC91565.1}; KW Mitochondrion inner membrane {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00093736}; KW NAD {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00464384}; KW Respiratory chain {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00464594}; KW Translocase {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS01109684}; KW Transmembrane {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00464491}; KW Transmembrane helix {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00093666}; Transport {ECO:0000256|SAAS:SAAS00464711}; KW Ubiquinone {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00464648}. FT TRANSMEM 25..44 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003403" FT TRANSMEM 50..70 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003403" FT TRANSMEM 82..102 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003403" FT TRANSMEM 122..145 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003403" FT TRANSMEM 166..184 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003403" FT DOMAIN 1..135 FT /note="Proton_antipo_M" FT /evidence="ECO:0000259|Pfam:PF00361" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AKC91565.1" FT NON_TER 185 FT /evidence="ECO:0000313|EMBL:AKC91565.1" SQ SEQUENCE 185 AA; 20437 MW; A7CD99573C361BC8 CRC64; IMLMAGMNAL VGGLMGMNQS QLRTIMAYSS IGHIGWMLSL LAVFKPNASI LYFMIYSMLI APLFMYMSYF NINSTKTMNK LASIKSSVPL VMTILLLSLG GLPPLTGFLP KFMTIMTLME SMKITVLLLI AGSVMNLYFY LNIAINLMIT SPTKKMMVPM NNNSDKYIII AMSGLSLGLT PLIMM //