ID A0A0E3GIF0_9FLAV Unreviewed; 495 AA. AC A0A0E3GIF0; DT 24-JUN-2015, integrated into UniProtKB/TrEMBL. DT 24-JUN-2015, sequence version 1. DT 20-DEC-2017, entry version 17. DE SubName: Full=Envelope protein {ECO:0000313|EMBL:AJQ21163.1}; DE Flags: Fragment; OS Dengue virus 2. OC Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage; OC Flaviviridae; Flavivirus; Dengue virus group. OX NCBI_TaxID=11060 {ECO:0000313|EMBL:AJQ21163.1}; RN [1] {ECO:0000313|EMBL:AJQ21163.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=SG {ECO:0000313|EMBL:AJQ21163.1}; RX PubMed=25846296; RA Ng L.C., Chem Y.K., Koo C., Mudin R.N., Amin F.M., Lee K.S., RA Kheong C.C.; RT "2013 dengue outbreaks in Singapore and Malaysia caused by different RT viral strains."; RL Am. J. Trop. Med. Hyg. 92:1150-1155(2015). CC -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane CC {ECO:0000256|SAAS:SAAS00536713}; Multi-pass membrane protein CC {ECO:0000256|SAAS:SAAS00536713}. Host endoplasmic reticulum CC membrane {ECO:0000256|SAAS:SAAS00536731}; Peripheral membrane CC protein {ECO:0000256|SAAS:SAAS00536731}; Lumenal side CC {ECO:0000256|SAAS:SAAS00536731}. Secreted CC {ECO:0000256|SAAS:SAAS00536690}. Virion membrane CC {ECO:0000256|SAAS:SAAS00944678}; Multi-pass membrane protein CC {ECO:0000256|SAAS:SAAS00944678}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KJ806785; AJQ21163.1; -; Genomic_RNA. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro. DR GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW. DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW. DR CDD; cd12149; Flavi_E_C; 1. DR Gene3D; 2.60.40.350; -; 1. DR Gene3D; 3.30.387.10; -; 1. DR Gene3D; 3.30.67.10; -; 1. DR InterPro; IPR013755; Flav_gly_cen_dom_subdom1. DR InterPro; IPR027287; Flavi_E_Ig-like. DR InterPro; IPR026470; Flavi_E_Stem/Anchor_dom. DR InterPro; IPR000336; Flavivir/Alphavir_Ig-like_sf. DR InterPro; IPR011998; Glycoprot_cen/dimer. DR InterPro; IPR036253; Glycoprot_cen/dimer_sf. DR InterPro; IPR013756; GlyE_cen_dom_subdom2. DR InterPro; IPR014756; Ig_E-set. DR Pfam; PF02832; Flavi_glycop_C; 1. DR Pfam; PF00869; Flavi_glycoprot; 1. DR SUPFAM; SSF56983; SSF56983; 1. DR SUPFAM; SSF81296; SSF81296; 1. DR TIGRFAMs; TIGR04240; flavi_E_stem; 1. PE 4: Predicted; KW Capsid protein {ECO:0000256|SAAS:SAAS00944784}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00139753}; KW Fusion of virus membrane with host endosomal membrane KW {ECO:0000256|SAAS:SAAS00489633}; KW Fusion of virus membrane with host membrane KW {ECO:0000256|SAAS:SAAS00489579}; KW Host endoplasmic reticulum {ECO:0000256|SAAS:SAAS00006452}; KW Host membrane {ECO:0000256|SAAS:SAAS00944684}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS00944679}; KW Membrane {ECO:0000256|SAAS:SAAS00944803, ECO:0000256|SAM:Phobius}; KW Secreted {ECO:0000256|SAAS:SAAS00007119}; KW Transmembrane {ECO:0000256|SAAS:SAAS00944695, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00944681, KW ECO:0000256|SAM:Phobius}; KW Viral attachment to host cell {ECO:0000256|SAAS:SAAS00944767}; KW Viral envelope protein {ECO:0000313|EMBL:AJQ21163.1}; KW Viral penetration into host cytoplasm {ECO:0000256|SAAS:SAAS00489650}; KW Virion {ECO:0000256|SAAS:SAAS00944743}; KW Virus entry into host cell {ECO:0000256|SAAS:SAAS00944744}. FT TRANSMEM 442 466 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 473 493 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 2 296 Flavi_glycoprot. {ECO:0000259|Pfam: FT PF00869}. FT DOMAIN 298 393 Flavi_glycop_C. {ECO:0000259|Pfam: FT PF02832}. FT NON_TER 1 1 {ECO:0000313|EMBL:AJQ21163.1}. FT NON_TER 495 495 {ECO:0000313|EMBL:AJQ21163.1}. SQ SEQUENCE 495 AA; 54210 MW; 0054E60A9EDE325C CRC64; MRCIGISNRD FVEGVSGGSW VDIVLEHGSC VTTMAKNKPT LDFELIKTEA KHPATLRKYC IEAKLTNTTT ASRCPTQGEP SLNEEQDKRF VCKHSMVDRG WGNGCGLFGK GGIVTCAMFT CKKNMEGKIV QPENLEYTIV ITPHSGEENA VGNDTGKHGK EIKVTPQSSI TEAELTGYGT VTMECSPRTG LDFNEMVLLQ MENKAWLVHR QWFLDLPLPW LPGADTQGSN WIQKETLVTF KNPHAKKQDV VVLGSQEGAM HTALTGATEI QMSSGNLLFT GHLKCRLRMD KLQLKGMSYS MCTGKFKVVK EIAETQHGTI VIRVQYEGDG SPCKIPFEIM DLEKRHVLGR LITVNPIVTE KDSPVNIEAE PPFGDSYVII GVEPGQLKLS WFKKGSSIGQ MFETTMRGAK RMAILGDTAW DFGSLGGVFT SIGKALHQVF GAIYGAAFSG VSWTMKILIG VVITWIGMNS RSTSLSVSLV LVGVVTLYLG VMVQA //