ID A0A0E2P7E7_9STRE Unreviewed; 451 AA. AC A0A0E2P7E7; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 18-JAN-2017, entry version 11. DE SubName: Full=RNA methyltransferase {ECO:0000313|EMBL:ETE06551.1}; GN ORFNames=U751_03635 {ECO:0000313|EMBL:ETE06551.1}; OS Streptococcus pseudopneumoniae 22725. OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; OC Streptococcus. OX NCBI_TaxID=1415759 {ECO:0000313|EMBL:ETE06551.1, ECO:0000313|Proteomes:UP000018701}; RN [1] {ECO:0000313|EMBL:ETE06551.1, ECO:0000313|Proteomes:UP000018701} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=22725 {ECO:0000313|EMBL:ETE06551.1, RC ECO:0000313|Proteomes:UP000018701}; RA Ikryannikova L.N., Lominadze G.G., Ilina E.N., Kostryukova E.S., RA Karpova I.Y., Semashko T.A., Larin A.K., Ischenko D.S., Mayansky N.A., RA Govorun V.M.; RT "Genome sequencing of Streptococcus pseudopneumoniae strains."; RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the class I-like SAM-binding CC methyltransferase superfamily. RNA M5U methyltransferase family. CC {ECO:0000256|PROSITE-ProRule:PRU01024, CC ECO:0000256|SAAS:SAAS00646055}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE06551.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AYRO01000005; ETE06551.1; -; Genomic_DNA. DR RefSeq; WP_000914557.1; NZ_AYRO01000005.1. DR EnsemblBacteria; ETE06551; ETE06551; U751_03635. DR Proteomes; UP000018701; Unassembled WGS sequence. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro. DR GO; GO:0006396; P:RNA processing; IEA:InterPro. DR Gene3D; 3.40.50.150; -; 1. DR InterPro; IPR001566; 23S_rRNA_MeTrfase_RlmD. DR InterPro; IPR030390; MeTrfase_TrmA_AS. DR InterPro; IPR030391; MeTrfase_TrmA_CS. DR InterPro; IPR012340; NA-bd_OB-fold. DR InterPro; IPR029063; SAM-dependent_MTases. DR InterPro; IPR002792; TRAM_dom. DR InterPro; IPR010280; U5_MeTrfase_fam. DR Pfam; PF05958; tRNA_U5-meth_tr; 1. DR SUPFAM; SSF50249; SSF50249; 1. DR SUPFAM; SSF53335; SSF53335; 1. DR TIGRFAMs; TIGR00479; rumA; 1. DR PROSITE; PS51687; SAM_MT_RNA_M5U; 1. DR PROSITE; PS50926; TRAM; 1. DR PROSITE; PS01230; TRMA_1; 1. DR PROSITE; PS01231; TRMA_2; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018701}; KW Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU01024, KW ECO:0000256|SAAS:SAAS00646063, ECO:0000313|EMBL:ETE06551.1}; KW S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU01024, KW ECO:0000256|SAAS:SAAS00646016}; KW Transferase {ECO:0000256|PROSITE-ProRule:PRU01024, KW ECO:0000256|SAAS:SAAS00646052, ECO:0000313|EMBL:ETE06551.1}. FT DOMAIN 1 59 TRAM. {ECO:0000259|PROSITE:PS50926}. FT ACT_SITE 408 408 {ECO:0000256|PROSITE-ProRule:PRU10015}. FT ACT_SITE 408 408 Nucleophile. {ECO:0000256|PROSITE- FT ProRule:PRU01024}. FT BINDING 283 283 S-adenosyl-L-methionine. FT {ECO:0000256|PROSITE-ProRule:PRU01024}. FT BINDING 312 312 S-adenosyl-L-methionine; via carbonyl FT oxygen. {ECO:0000256|PROSITE-ProRule: FT PRU01024}. FT BINDING 333 333 S-adenosyl-L-methionine. FT {ECO:0000256|PROSITE-ProRule:PRU01024}. FT BINDING 381 381 S-adenosyl-L-methionine. FT {ECO:0000256|PROSITE-ProRule:PRU01024}. SQ SEQUENCE 451 AA; 50985 MW; 891E0FD3D91199C1 CRC64; MLKKNDIVEV EIVDLTHEGA GVAKVDGLVF FVENALPSEK ILMRVLKVNK KIGFGKVEEY LVQSPHRNQD LDLAYLRSGI ADLGHLAYPE QLKFKTKQVK DSLYKIAGID DIEVAETLGM ENPVKYRNKA QVPVRRVNGV LETGFFRKNS HDLMPLEDFF IQDSVIDEVV VGLRDLLRRY DLKPYDEKEQ SGLIRNLVVR RGHYSGQIMV ILVTTRPKVF RVDQLIEQVI KQFPEIVSVM QNINDQNTNA IFGKEWRTLY GQDFITDQML GNDYQIAGPA FYQVNTEMAE KLYQTAIDFA ELKEDDVVID AYSGIGTIGI SVAKHVKEVY GVEVIPEAVE NSKKNAQLNN ISNANYVCDT AENAMKNWLK DGIQPSLILV DPPRKGLTES FIKASTQTGA NRIAYISCNV ATMARDIKLY QELGYELKKV QPVDLFPQTH HVECVALLVK T //