ID A0A0D9QZB3_CHLSB Unreviewed; 536 AA. AC A0A0D9QZB3; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 11-MAY-2016, entry version 10. DE RecName: Full=Phosphodiesterase {ECO:0000256|RuleBase:RU363067}; DE EC=3.1.4.- {ECO:0000256|RuleBase:RU363067}; GN Name=PDE1B {ECO:0000313|Ensembl:ENSCSAP00000001702}; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000001702, ECO:0000313|Proteomes:UP000029965}; RN [1] {ECO:0000313|Ensembl:ENSCSAP00000001702, ECO:0000313|Proteomes:UP000029965} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCSAP00000001702} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC -!- COFACTOR: CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; CC Evidence={ECO:0000256|RuleBase:RU363067}; CC Note=Binds 2 divalent metal cations per subunit. Site 1 may CC preferentially bind zinc ions, while site 2 has a preference for CC magnesium and/or manganese ions. {ECO:0000256|RuleBase:RU363067}; CC -!- SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase CC family. {ECO:0000256|RuleBase:RU363067, CC ECO:0000256|SAAS:SAAS00540521}. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSCSAP00000001702}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AQIB01022982; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_008001716.1; XM_008003525.1. DR ProteinModelPortal; A0A0D9QZB3; -. DR Ensembl; ENSCSAT00000003423; ENSCSAP00000001702; ENSCSAG00000005388. DR GeneID; 103238444; -. DR CTD; 5153; -. DR GeneTree; ENSGT00760000118889; -. DR OMA; LMQDDEM; -. DR Proteomes; UP000029965; Chromosome 11. DR GO; GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 1.10.1300.10; -; 2. DR InterPro; IPR003607; HD/PDEase_dom. DR InterPro; IPR023088; PDEase. DR InterPro; IPR002073; PDEase_catalytic_dom. DR InterPro; IPR023174; PDEase_CS. DR InterPro; IPR013706; PDEase_N. DR Pfam; PF00233; PDEase_I; 1. DR Pfam; PF08499; PDEase_I_N; 1. DR PRINTS; PR00387; PDIESTERASE1. DR SMART; SM00471; HDc; 1. DR PROSITE; PS00126; PDEASE_I; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000029965}; KW Hydrolase {ECO:0000256|RuleBase:RU363067, KW ECO:0000256|SAAS:SAAS00540518}; KW Metal-binding {ECO:0000256|RuleBase:RU363067, KW ECO:0000256|SAAS:SAAS00540563}; KW Reference proteome {ECO:0000313|Proteomes:UP000029965}. FT DOMAIN 220 384 HDc. {ECO:0000259|SMART:SM00471}. SQ SEQUENCE 536 AA; 61365 MW; 5B0F82829574B9C6 CRC64; MELSPRSPPE MLEESDCPSP LELKSAPSKK MWIKLRSLLR YMVKQLENGE VNIEELKKNL EYTASLLEAV YIDETRQILD TEDELQELRS DAVPSEVRDW LASTFTQQAR AKGRRAEEKP KFRSIVHAVQ AGIFVERMFR RTYTSVGPTY STAVLNCFKN LDLWCFDVFS LNRAADDHAL RTIVFELLTR HNLISRFKIP TVFLMSFLDA LETGYGKYKN PYHNQIHAAD VTQTVHCFLL RTGMVHCLSE IEVLAIIFAA AIHDYEHTGT TNSFHIQTKS ECAILYNDRS VLENHHISSV FRLMQDDELN IFINLTKDEF VELRALVIEM VLATDMSCHF QQVKTMKTAL QQLERIDKPK ALSLLLHAAD ISHPTKQWSV HSRWTKALME EFFRQGDKEA ELGLPFSPLC DRTSTLVAQS QIGFIDFIVE PTFSVLTDVA EKSVQPLADE DSKSKNQPSF QWRQPSLDVE VGDPNPDVVS FRSTWIKHIQ ENKQKWKERA ASGITNQMSI DELSPCDEEA PPSPAEDEHN QNGNLD //