ID A0A0D5CAH8_ECOLX Unreviewed; 169 AA. AC A0A0D5CAH8; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 08-MAY-2019, entry version 12. DE RecName: Full=Beta-lactamase {ECO:0000256|SAAS:SAAS00063099}; DE EC=3.5.2.6 {ECO:0000256|SAAS:SAAS00063099}; DE Flags: Fragment; GN Name=blaCTX-M-27 {ECO:0000313|EMBL:AJW75145.1}; OS Escherichia coli. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=562 {ECO:0000313|EMBL:AJW75145.1}; RN [1] {ECO:0000313|EMBL:AJW75145.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=18 {ECO:0000313|EMBL:AJW75145.1}; RA Altayb H.N., El Amin N.M., Mukhtar M.M., Hassan M.A., Siddig M.A.; RT "Molecular Characterization of CTX-M Beta-Lactamases Genes among RT Pathogenic Enterobacteriaceae isolated from different regions in RT Sudan."; RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid; CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627, CC ChEBI:CHEBI:140347; EC=3.5.2.6; CC Evidence={ECO:0000256|SAAS:SAAS01122538}; CC -!- SIMILARITY: Belongs to the class-A beta-lactamase family. CC {ECO:0000256|SAAS:SAAS00559532}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KP317202; AJW75145.1; -; Genomic_DNA. DR GO; GO:0008800; F:beta-lactamase activity; IEA:UniProtKB-EC. DR GO; GO:0030655; P:beta-lactam antibiotic catabolic process; IEA:InterPro. DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW. DR InterPro; IPR012338; Beta-lactam/transpept-like. DR InterPro; IPR000871; Beta-lactam_class-A. DR PRINTS; PR00118; BLACTAMASEA. DR SUPFAM; SSF56601; SSF56601; 1. PE 3: Inferred from homology; KW Antibiotic resistance {ECO:0000256|SAAS:SAAS00129359}; KW Hydrolase {ECO:0000256|SAAS:SAAS00129356}. FT NON_TER 1 1 {ECO:0000313|EMBL:AJW75145.1}. FT NON_TER 169 169 {ECO:0000313|EMBL:AJW75145.1}. SQ SEQUENCE 169 AA; 17760 MW; FB53554CE8969CAE CRC64; MAAAAVLKQS ETQKQLLNQP VEIKPADLVN YNPIAEKHVN GTMTLAELSA AALQYSDNTA MNKLIAQLGG PGGVTAFARA IGDETFRLDR TEPTLNTAIP GDPRDTTTPR AMAQTLRQLT LGHALGETQR AQLVTWLKGN TTGAASIRAG LPTSWTVGDK TGSGGYGTT //