ID A0A0C9QKP6_BIOGL Unreviewed; 300 AA. AC A0A0C9QKP6; DT 29-APR-2015, integrated into UniProtKB/TrEMBL. DT 29-APR-2015, sequence version 1. DT 24-JAN-2024, entry version 31. DE RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119}; DE EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119}; GN Name=plmt {ECO:0000313|EMBL:JAG85125.1}; OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail). OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda; OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea; OC Planorbidae; Biomphalaria. OX NCBI_TaxID=6526 {ECO:0000313|EMBL:JAG85125.1}; RN [1] {ECO:0000313|EMBL:JAG85125.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Guadeloupe {ECO:0000313|EMBL:JAG85125.1}; RC TISSUE=Whole body {ECO:0000313|EMBL:JAG85125.1}; RA Tennessen J.A., Blouin M.S.; RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:JAG85125.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Guadeloupe {ECO:0000313|EMBL:JAG85125.1}; RC TISSUE=Whole body {ECO:0000313|EMBL:JAG85125.1}; RA Theron A., Marine M., Yeh J.-Y., Rognon A.; RT "Hyperdiverse gene cluster in snail host conveys resistance to human RT schistosome parasites."; RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- CC hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- CC COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; CC EC=2.3.1.225; Evidence={ECO:0000256|RuleBase:RU079119}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity. CC {ECO:0000256|RuleBase:RU079119}. CC -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family. CC {ECO:0000256|RuleBase:RU079119}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GBYU01000014; JAG85125.1; -; Transcribed_RNA. DR AlphaFoldDB; A0A0C9QKP6; -. DR VEuPathDB; VectorBase:BGLB017394; -. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC. DR InterPro; IPR001594; Palmitoyltrfase_DHHC. DR PANTHER; PTHR22883:SF147; PALMITOYLTRANSFERASE; 1. DR PANTHER; PTHR22883; ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN; 1. DR Pfam; PF01529; DHHC; 1. DR PROSITE; PS50216; DHHC; 1. PE 3: Inferred from homology; KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315, KW ECO:0000256|RuleBase:RU079119}; Membrane {ECO:0000256|RuleBase:RU079119}; KW Transferase {ECO:0000256|RuleBase:RU079119}; KW Transmembrane {ECO:0000256|RuleBase:RU079119}; KW Transmembrane helix {ECO:0000256|RuleBase:RU079119}. FT TRANSMEM 12..33 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU079119" FT TRANSMEM 39..57 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU079119" FT TRANSMEM 160..184 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU079119" FT TRANSMEM 204..226 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU079119" FT DOMAIN 115..240 FT /note="Palmitoyltransferase DHHC" FT /evidence="ECO:0000259|Pfam:PF01529" SQ SEQUENCE 300 AA; 34469 MW; 714A33C504B02CEA CRC64; MSIWGWVPPL VISMVAVYTY YAYVVAMCIM TSNLLAEKVI LILVFHALFA MSVWCFVRSV WTRPMKPTVK YALEEAEWSK MSYDYNWKKE REAMSNLRQK VGIITTASDT GDGLLQYCFH CRNLKPDRCH HCSRCGMCVL KMDHHCPWVN NCVGFHNYKY FLLFLSYSSF GVIFVIFTSA RFIYEFVINA RHLGLASAVS GNVLVILIML VIHVLVGIAL SPLLYLHRDL VAHNVTTLEN SRPVGVYGTR PSYKTFDMGL QANFVQIFGE RKLYWFFPVF TSQGDGMTFP ISTYKKTEIA //