ID A0A0C4ZQW2_9TELE Unreviewed; 173 AA. AC A0A0C4ZQW2; DT 29-APR-2015, integrated into UniProtKB/TrEMBL. DT 29-APR-2015, sequence version 1. DT 14-DEC-2022, entry version 24. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6 {ECO:0000256|ARBA:ARBA00021095, ECO:0000256|RuleBase:RU004430}; DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU004430}; GN Name=ND6 {ECO:0000313|EMBL:AJJ48735.1}; OS Cyprinus carpio 'Furong' x Carassius auratus red var. OG Mitochondrion {ECO:0000313|EMBL:AJJ48735.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinoidei intergeneric hybrids. OX NCBI_TaxID=1610701 {ECO:0000313|EMBL:AJJ48735.1}; RN [1] {ECO:0000313|EMBL:AJJ48735.1} RP NUCLEOTIDE SEQUENCE. RA Peng H.Z., Xiao T.Y.; RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AJJ48735.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=25648921; RA Peng H., Liu Q., Xiao T.; RT "Inheritance of the complete mitochondrial genomes Cyprinus capio RT furong(female symbol) x Cyprinus carpio var.singguonensis(male symbol)."; RL Mitochondrial DNA 1-2:0-0(2015). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from CC NADH through the respiratory chain, using ubiquinone as an electron CC acceptor. Essential for the catalytic activity and assembly of complex CC I. {ECO:0000256|RuleBase:RU004430}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000256|RuleBase:RU004430}; CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane CC {ECO:0000256|RuleBase:RU004430}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU004430}. CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. CC {ECO:0000256|RuleBase:RU004430}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KP210473; AJJ48735.1; -; Genomic_DNA. DR RefSeq; YP_009122676.1; NC_026543.1. DR AlphaFoldDB; A0A0C4ZQW2; -. DR GeneID; 23630071; -. DR CTD; 4541; -. DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-UniRule. DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6. DR Pfam; PF00499; Oxidored_q3; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|RuleBase:RU004430}; KW Membrane {ECO:0000256|RuleBase:RU004430}; KW Mitochondrion {ECO:0000256|RuleBase:RU004430, ECO:0000313|EMBL:AJJ48735.1}; KW NAD {ECO:0000256|RuleBase:RU004430}; KW Respiratory chain {ECO:0000256|RuleBase:RU004430}; KW Signal {ECO:0000256|SAM:SignalP}; KW Translocase {ECO:0000256|RuleBase:RU004430}; KW Transmembrane {ECO:0000256|RuleBase:RU004430}; KW Transmembrane helix {ECO:0000256|RuleBase:RU004430}; KW Transport {ECO:0000256|RuleBase:RU004430}; KW Ubiquinone {ECO:0000256|RuleBase:RU004430}. FT SIGNAL 1..20 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 21..173 FT /note="NADH-ubiquinone oxidoreductase chain 6" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5002182152" FT TRANSMEM 51..75 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004430" FT TRANSMEM 87..110 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004430" FT TRANSMEM 130..159 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004430" SQ SEQUENCE 173 AA; 18053 MW; 88E9BA5CA1EA56A2 CRC64; MTYFMFLLLM ALVVGLVAVA SNPTPYFAAL GLVVAAGVGC GVLVGHGGSF LSLVLFLIYL GGMLVVFAYS AALAAEPFPE AWGIRSVLGY VLVYLLGVGL VAGIFWGGWY EGSWVVVDGL KEFSVLRGDI SGVAVMYSSG GGILVICAWV VLLTLLVVLE LTRGLSRGAL RAV //